Recommended Readings: Jon Clardy, Ph.D. March 24, 2017

Friday Lectures

Friday, March 24, 2017   3:45 p.m.

Caspary Auditorium

Jon Clardy, Ph.D.

Hsien Wu and Daisy Yen Wu Professor,

Department of Biological Chemistry and Molecular Pharmacology

The Rockefeller University

Small Molecule Modulators of Multilateral Symbioses

Recommended Readings:

https://www.sciencedaily.com/releases/2017/02/170215084450.htm

Pupo, Monica T.; Currie, Cameron R.; Clardy, Jon (2017). Microbial Symbionts of Insects are the Focus of the First International Cooperative Biodiversity Group (ICBG) in Brazil. JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY. 28 (3): 393-401

Ruzzini, Antonio C.; Clardy, Jon (2016). Gene Flow and Molecular Innovation in Bacteria. CURRENT BIOLOGY. 26(18)R859-R864

Cantley, Alexandra M.; Clardy, Jon (2015). Animals in a bacterial world: opportunities for chemical ecology.  NATURAL PRODUCT REPORTS. 32(7): 888-892

Sit, Clarissa S.; Ruzzini, Antonio C.; Van Arnam, Ethan B.; et al. (2015). Variable genetic architectures produce virtually identical molecules in bacterial symbionts of fungus-growing ants. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112(43)13150-13154

Ramadhar, Timothy R.; Beemelmanns, Christine; Currie, Cameron R.; et al. (2014). Bacterial symbionts in agricultural systems provide a strategic source for antibiotic discover. JOURNAL OF ANTIBIOTICS. 67(1): 53-58

Crawford, Jason M.; Clardy, Jon (2011). Bacterial symbionts and natural products. CHEMICAL COMMUNICATIONS. 47(27): 7559-7566

Oh, Dong-Chan; Poulsen, Michael; Currie, Cameron R.; et al. (2009). Dentigerumycin: a bacterial mediator of an ant-fungus symbiosis.  NATURE CHEMICAL BIOLOGY. 5(6) 391-393

 

 

 

Recommended Readings: Elly Tanaka, Ph.D. March 17, 2017

Friday Lectures

Friday, March 17, 2017   3:45 p.m.

Caspary Auditorium

Elly Tanaka, Ph.D.

Senior Scientist,

Research Institute of Molecular Pathology, Vienna, Austria

The Control of Growth, Signaling, and Patterning during Vertebrate Limb Regeneration

Recommended Readings:

https://medicalxpress.com/news/2017-03-inflammation-regeneration-friend-foe.html

Tanaka, Elly M. (2016). The Molecular and Cellular Choreography of Appendage on Regeneration. CELL. 165(7): 1598-1608

Tornini, Valerie A.; Puliafito, Alberto; Slota, Leslie A.; et al. (2016). Live Monitoring of Blastemal Cell Contributions during Appendage Regeneration. CURRENT BIOLOGY. 26(22): 2981-2991 

Sandoval-Guzman, Tatiana; Wang, Heng; Khattak, Shahryar; et al. (2014). Fundamental Differences in Dedifferentiation and Stem Cell Recruitment during Skeletal Muscle Regeneration in Two Salamander Species. CELL STEM CELL. 14(2): 174-187

Khattak, Shahryar; Schuez, Maritta; Richter, Tobias; et al. (2013). Germline Transgenic Methods for Tracking Cells and Testing Gene Function during Regeneration in the Axolotl. STEM CELL REPORTS. 1(1): 90-103

Simon, Andras; Tanaka, Elly M. (2013). Limb regeneration.  WILEY INTERDISCIPLINARY REVIEWS-DEVELOPMENTAL BIOLOGY. 2(2): 291-300

Recommended Readings: Nancy Kanwisher, Ph.D. March 10, 2017

Friday Lectures

Friday, March 10, 2017   3:45 p.m.

Caspary Auditorium

Nancy Kanwisher, Ph.D.

Walter A. Rosenblith Professor,

Department of Brain and Cognitive Sciences,

Massachusetts Institute of Technology

Functional Imaging of the Human Brain:  A Window into the Organization of the Human Mind

Recommended Readings:

http://nancysbraintalks.mit.edu/video/nancys-ted-talk-neural-portrait-human-mind

https://www.theguardian.com/science/neurophilosophy/2017/jan/05/face-selective-brain-region-continues-to-grow-in-adulthood

Osher, David E.; Saxe, Rebecca R.; Koldewyn, Kami; et al. (2016). Structural Connectivity Fingerprints Predict Cortical Selectivity for Multiple Visual Categories across Cortex. CEREBRAL CORTEX. 26(4): 1668-1683
Yovel, Galit; Belin, Pascal (2013). A unified coding strategy for processing faces and voices. TRENDS IN COGNITIVE SCIENCES. 17(6): 263-271
Kanwisher, Nancy (2010). Functional specificity in the human brain: A window into the functional architecture of the mind. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 107(25): 11163-11170
Kanwisher, Nancy; Yovel, Galit (2006). The fusiform face area: a cortical region specialized for the perception of faces. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES. 361(1476): 2109-2128


 

Recommended Readings: Leslie B. Vosshall, Ph.D. March 3, 2017

Friday Lectures

Friday, March 03, 2017   3:45 p.m.

Caspary Auditorium

Leslie B. Vosshall, Ph.D.

Robin Chemers Neustein Professor and Head,

Laboratory of Neurogenetics and Behavior,

The Rockefeller University

NEUROBIOLOGY OF THE WORLD’S MOST DANGEROUS ANIMAL

Recommended Readings:

Bezzina A. Malaria infection smells irresistible to mosquitoes. Cosmos. Feb 9 2017

Hurd H. Afraid of malaria? Get a chicken. BMC Blogs Network (blog). Aug 16 2016

Matthews, Benjamin J.; McBride, Carolyn S.; DeGennaro, Matthew; et al. (2016). The neurotranscriptome of the Aedes aegypti mosquito. BMC GENOMICS. 17(32)

Kistler, Kathryn E.; Vosshall, Leslie B.; Matthews, Benjamin J. (2015). Genome Engineering with CRISPR-Cas9 in the Mosquito Aedes aegypti. CELL REPORTS. 11(1): 51-60

McBride, Carolyn S.; Baier, Felix; Omondi, Aman B.; et al. (2014). Evolution of mosquito preference for humans linked to an odorant receptor. NATURE. 515(7526): 222-U151

McMeniman, Conor J.; Corfas, Roman A.; Matthews, Benjamin J.; et al. (2014). Multimodal Integration of Carbon Dioxide and Other Sensory Cues Drives Mosquito Attraction to Humans. CELL. 156(5): 1060-1071  

Takken, Willem; Verhulst, Niels O. (2013). Host Preferences of Blood-Feeding Mosquitoes.
ANNUAL REVIEW OF ENTOMOLOGY. 58: 433-453

Recommended Readings: Jeffrey M. Friedman, M.D., Ph.D.

Friday Lectures

Friday, February 24, 2017   3:45 p.m.

Caspary Auditorium

Jeffrey M. Friedman,  M.D., Ph.D.

Marilyn M. Simpson Professor and Head,

Laboratory of Molecular Genetics

The Rockefeller University

Leptin Physiology, Pathophysiology and

the Neural Circuit Regulating Body Weight

 

Recommended Readings:

Friedman, Jeffrey (2016). The long road to leptin. JOURNAL OF CLINICAL INVESTIGATION. 126(12): 4727-4734

Friedman, Jeffrey M.; Mantzoros, Christos S. (2015). 20 years of leptin: From the discovery of the leptin gene to leptin in our therapeutic armamentarium. METABOLISM-CLINICAL AND EXPERIMENTAL. 64(1): 1-4   PLEASE REQUEST FROM MARKUS LIBRARY

Bouret, Sebastien G.; Bates, Sarah H.; Chen, Stephen; et al. (2012). Distinct Roles for Specific Leptin Receptor Signals in the Development of Hypothalamic Feeding Circuits. JOURNAL OF NEUROSCIENCE. 32(4): 1244-1252

Domingos, Ana I.; Vaynshteyn, Jake; Voss, Henning U.; et al. (2011). Leptin regulates the reward value of nutrient. NATURE NEUROSCIENCE. 14(12): 1562-U92

Davis, Jon F.; Choi, Derrick L.; Schurdak, Jennifer D.; et al. (2011). Leptin Regulates Energy Balance and Motivation Through Action at Distinct Neural Circuits BIOLOGICAL PSYCHIATRY. 69(7): 668-674

Mantzoros, Christos S.; Magkos, Faidon; Brinkoetter, Mary; et al. (2011). Leptin in human physiology and pathophysiology.  AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 301(4): E567-E584

Wang, May-yun; Chen, Lijun; Clark, Gregory O.; et al. (2010). Leptin therapy in insulin-deficient type I diabetes. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 107(11): 4813-4819

Oral, EA; Simha, V; Ruiz, E; et al. (2002). Leptin-replacement therapy for lipodystrophy. NEW ENGLAND JOURNAL OF MEDICINE. 346(8): 570-578

 

 

Recommended Readings: Edward S. Boyden Ph.D. Friday February 17, 2017

Friday Lectures

Friday, February 17, 2017   3:45 p.m.

Caspary Auditorium

Edward S. Boyden,  Ph.D.

Associate Professor

MIT Media Lab

Optical Tools for Analyzing and Repairing

Complex Biological Systems

Recommended Readings:

Boyden, Edward S. (2015). Optogenetics and the future of neuroscience. NATURE NEUROSCIENCE. 18(12): 1862-1862

Chen, Fei; Tillberg, Paul W.; Boyden, Edward S. (2015). Expansion microscopy. SCIENCE. 347(6221): 543-548   

Madisen, Linda; Mao, Tianyi; Koch, Henner; et al. (2012). A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing. NATURE NEUROSCIENCE. 15(5): 793-802

Bernstein, Jacob G.; Garrity, Paul A.; Boyden, Edward S.  (2012). Optogenetics and thermogenetics: technologies for controlling the activity of targeted cells within intact neural circuits. CURRENT OPINION IN NEUROBIOLOGY.   22(1): 61-71

 

 

Recommended Readings: Ian A. Wilson D. Phil., D. Sci., Friday February 10, 2017

Friday Lectures

Friday, February 10, 2017   3:45 p.m.

Caspary Auditorium

Ian A. Wilson  D. Phil., D.Sci.

Hansen Professor of Structural Biology, and

Chair, Dept. of Integrative Structural and Computational Biology

The Scripps Research Institute

Broad Neutralization of Influenza Viruses and

Implications for a Universal Vaccine and Therapy

Recommended Readings:

Dreyfus, Cyrille; Laursen, Nick S.; Kwaks, Ted; et al.  (2012). Highly Conserved Protective Epitopes on Influenza B Viruses.  SCIENCE, 337(6100): 1343-1348 

Walker, Laura M.; Huber, Michael; Doores, Katie J.; et al. (2011).  Broad neutralization coverage of HIV by multiple highly potent antibodiesNATURE , 477(7365): 466-U117

Ekiert, Damian C.; Friesen, Robert H. E.; Bhabha, Gira; et al. (2011).  A Highly Conserved Neutralizing Epitope on Group 2 Influenza A VirusesSCIENCE,  333(6044): 843-850 

Gottlieb, Tanya; Ben-Yedidia, Tamar.  (2014)  Epitope-based approaches to a universal influenza vaccine.  JOURNAL OF AUTOIMMUNITY.  54 (Special Issue: SI ):15-20 

He, Fang; Prabakaran, Mookkan; Kumar, Subaschandrabose Rajesh; et al. (2011), Monovalent H5 vaccine based on epitope-chimeric HA provides broad cross-clade protection against variant H5N1 viruses in miceANTIVIRAL RESEARCH,  105: 143-151 

Li, Zhuo; Gabbard, Jon D.; Mooney, Alaina; et al. (2013). Single-Dose Vaccination of a Recombinant Parainfluenza Virus 5 Expressing NP from H5N1 Virus Provides Broad Immunity against Influenza A Viruses.  JOURNAL OF VIROLOGY,  87(10): 5985-5993

Huber, Victor C.; Thomas, Paul G.; McCullers, Jonathan A. (2009).  A multi-valent vaccine approach that elicits broad immunity within an influenza subtypeVACCINE,  27(8): 1192-1200

Recommended Readings: Stuart H. Orkin M.D. January 6 2017

Friday Lectures

Friday, January 6,  3:45 p.m.

Caspary Auditorium

Stuart H. Orkin   M.D.

David G. Nathan Distinguished Professor of Pediatrics, Dana Farber Institute

The Human Fetal Globin Switch:

A Paradigm for Disease-related Common Genetic Variation in Regulatory Elements

Recommended Readings:

Bauer, Daniel E.; Kamran, Sophia C.; Lessard, Samuel; et al.  An Erythroid Enhancer of BCL11A Subject to Genetic Variation Determines Fetal Hemoglobin Level.  SCIENCE  342(6155): 253-257    OCT 11 2013  

Galarneau, Genevieve; Palmer, Cameron D.; Sankaran, Vijay G.; et al.  Fine-mapping at three loci known to affect fetal hemoglobin levels explains additional genetic variation.  NATURE GENETICS   42(12): 1049-1051   DEC 2010

Menzel, Stephan; Thein, Swee Lay.   Genetic architecture of hemoglobin F control. CURRENT OPINION IN HEMATOLOGY   16(3): 179-186   MAY 2009  PLEASE REQUEST FROM MARKUS LIBRARY

He, Yunyan; Lin, Weixiong; Luo, Jianming.  Influences of Genetic Variation on Fetal Hemoglobin. PEDIATRIC HEMATOLOGY AND ONCOLOGY   Volume: 28   Issue: 8   Pages: 708-717   Published:  NOV 2011   PLEASE REQUEST FROM MARKUS LIBRARY.

Orkin, Stuart H.  Recent advances in globin research using genome-wide association studies and gene editing. Annals of the New York Academy of Sciences   1368 : 5-10    2016

Recommended Readings: Maria Barna Ph.D. Friday December 9, 2016

Friday Lectures

Friday, December 9, 2016   3:45 p.m.

Caspary Auditorium

Maria Barna, Ph.D.

Assistant Professor,

Departments of Developmental Biology and Genetics at Stanford University

Specialized Ribosomes:

A New Frontier in Gene Regulation, Organismal Biology, & Evolution

Recommended Readings:

Xue, Shifeng; Barna, Maria.   Specialized ribosomes: a new frontier in gene regulation and organismal biology.  NATURE REVIEWS MOLECULAR CELL BIOLOGY    13( 6):355-369     JUN 2012

Amunts, Alexey; Brown, Alan; Bai, Xiao-chen; et al.  Structure of the Yeast Mitochondrial Large Ribosomal Subunit.  SCIENCE   343(6178):1485-1489      MAR 28 2014

Xue, Shifeng; Tian, Siqi; Fujii, Kotaro; et al.  RNA regulons in Hox 5 ‘ UTRs confer ribosome specificity to gene regulation. NATURE   517(7532):33-U55   JAN 1 2015

Wu, XQ; Iyengar, P; RajBhandary, UL.   Ribosome-initiator tRNA complex as an intermediate in translation initiation in Escherichia coli revealed by use of mutant initiator tRNAs and specialized ribosomes. EMBO JOURNAL    15(17):4734-4739  SEP 2 1996

Shi, Zhen; Barna, Maria   Trransiating the Genome in Time and Space: Specialized Ribosomes, RNA. Regulons, and RNA-Binding Proteins. ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 31   Book Series: Annual Review of Cell and Developmental Biology   V. 31: 31-+    2015

Yadav, Anupama; Radhakrishnan, Aparna; Panda, Anshuman; et al. The Modular Adaptive Ribosome.   PLOS ONE   11(11): Article Number: e0166021    NOV 3 2016

 

Recommended Readings: Tania Baker Ph.D. Friday, November 18, 2016

Friday Lectures

Friday, November 18, 2016   3:45 p.m.

Caspary Auditorium

Tania Baker, Ph.D.

Edwin C. Whitehead Professor of Biology, MIT

Investigator, HHMI

Operations of AAA+ Unfoldase Motors:

Powerful Destroyers and Activators of Protein Function

Selected Publications:

Baker, Tania A.; Sauer, Robert T.  ClpXP, an ATP-powered unfolding and protein-degradation machine.    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH.   1823(Special Issue SI): 15-28     JAN 2012

Stinson, Benjamin M.; Nager, Andrew R.; Glynn, Steven E.; et al.  Nucleotide Binding and Conformational Switching in the Hexameric Ring of a AAA plus Machine. CELL   153(3):628-639    APR 25 2013

Glynn, Steven E.; Nager, Andrew R.; Baker, Tania A.; et al.   Dynamic and static components power unfolding in topologically closed rings of a AAA plus proteolytic machine.   NATURE STRUCTURAL & MOLECULAR BIOLOGY.  19(6):616-+   JUN 2012

Cordova, Juan Carlos; Olivares, Adrian O.; Shin, Yongdae; et al.    Stochastic but Highly Coordinated Protein Unfolding and Translocation by the ClpXP Proteolytic Machine.  CELL    158(3): 647-658     JUL 31 2014

Olivares, Adrian O.; Nager, Andrew R.; Iosefson, Ohad; et al.   Mechanochemical basis of protein degradation by a double-ring AAA plus machine.   NATURE STRUCTURAL & MOLECULAR BIOLOGY    21(10): 871-875    OCT 2014