Gunter Blobel: Honoring the life and work of a Rockefeller Nobel Laureate

The Markus Library is pleased to present a new exhibit in Welch Hall (level 2) honoring an extraordinary human being, molecular biologist, and Rockefeller scientist, Gunter Blobel.  Dr. Blobel came to Rockefeller in 1962, joining the cell biology laboratory of George Palade who became his mentor and friend.  Dr. Blobel won the Nobel prize in 1999 and donated the entire sum to restoration projects in the city Dresden.

Recommended Readings: David Pellman, M.D. Friday June 1, 2018

Friday Lectures

Friday, June 1, 2018  3:45 p.m.

Caspary Auditorium

David Pellman M.D.

Margaret M. Dyson Professor

Department of Cell Biology

Harvard Medical School

Mechanisms of Rapid Genome Evolution

Recommended Readings:

Science News

Dana-Farber Cancer Institute. Researchers identify origin of chromosomal oddity in some cancer cells. May 27, 2015. EurekAlert

Empirical Articles

Marteil, Gaelle; Guerrero, Adan; Vieira, Andre F.; et al. (2018). Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation. NATURE COMMUNICATIONS. 9    

Zhang, Cheng-Zhong; Spektor, Alexander; Cornils, Hauke; et al. (2015). Chromothripsis from DNA damage in micronuclei. NATURE. 522 (7555): 179-+

Selmecki, Anna M.; Maruvka, Yosef E.; Richmond, Phillip A.; et al. (2015). Polyploidy can drive rapid adaptation in yeast. NATURE. 519 (7543): 349-+

Crasta, Karen; Ganem, Neil J.; Dagher, Regina; et al. (2012). DNA breaks and chromosome pulverization from errors in mitosis. NATURE. 482 (7383): 53-U70

Carter, Scott L.; Cibulskis, Kristian; Helman, Elena; et al. (2012). Absolute quantification of somatic DNA alterations in human cancer. NATURE BIOTECHNOLOGY. 30 (5): 413-+

Ganem, Neil J.; Godinho, Susana A.; Pellman, David. (2009). A mechanism linking extra centrosomes to chromosomal instability. NATURE. 460 (7252): 278-U146

Review Paper

Zhang, Cheng-Zhong; Leibowitz, Mitchell L.; Pellman, David. (2013). Chromothripsis and beyond: rapid genome evolution from complex chromosomal rearrangements. GENES AND DEVELOPMENT. 27 (23): 2513-2530   

Gordon, David J.; Resio, Benjamin; Pellman, David. (2012). Causes and consequences of aneuploidy in cancer. NATURE REVIEWS GENETICS. 13 (3): 189-203

Book Chapter

Leibowitz, Mitchell L.; Zhang, Cheng-Zhong; Pellman, David. (2015). Chromothripsis: A New Mechanism for Rapid Karyotype Evolution. ANNUAL REVIEW OF GENETICS. 49: 183-211

Recommended Readings: Stephen Elledge, Ph.D. Friday May 18, 2018

Friday Lectures

Friday, May 18, 2018  3:45 p.m.

Caspary Auditorium

Stephen J. Elledge Ph.D.

Gregor Mendel Professor

Department of Genetics

Harvard Medical School

Microgenetics: What We Can Learn About Protein Degradation from Bits of Genes

Recommended Readings:

Science News

Your viral infection history in a single drop of blood. June 4, 2015. ScienceDaily

Empirical Articles

Sack, Laura Magill; Davoli, Teresa; Li, Mamie Z.; et al. (2018). Profound Tissue Specificity in Proliferation Control Underlies Cancer Drivers and Aneuploidy Patterns. CELL. 173 (2): 499-+

Liao, Sida; Davoli, Teresa; Leng, Yumei; et al. (2017). A genetic interaction analysis identifies cancer drivers that modify EGFR dependency. GENES AND DEVELOPMENT. 31 (2): 184-196

Xu, George J.; Kula, Tomasz; Xu, Qikai; et al. (2015). Comprehensive serological profiling of human populations using a synthetic human virome. SCIENCE. 348 (6239)

Emanuele, Michael J.; Elia, Andrew E. H.; Xu, Qikai; et al. (2011). Global Identification of Modular Cullin-RING Ligase Substrates. CELL. 147 (2): 459-474

Larman, H. Benjamin; Zhao, Zhenming; Laserson, Uri; et al. (2011). Autoantigen discovery with a synthetic human peptidome. NATURE BIOTECHNOLOGY. 29 (6): 535-U101

Yen, Hsueh-Chi Sherry; Xu, Qikai; Chou, Danny M.; et al. (2008). Global Protein Stability Profiling in Mammalian Cells. SCIENCE. 322 (5903): 918-923

Yen, Hsueh-Chi Sherry; Elledge, Stephen J. (2008). Identification of SCF Ubiquitin Ligase Substrates by Global Protein Stability Profiling. SCIENCE. 322 (5903): 923-929

Review Paper

Ciccia, Alberto; Elledge, Stephen J. (2010). The DNA Damage Response: Making It Safe to Play with Knives. MOLECULAR CELL. 40 (2): 179-204

Luo, Ji; Solimini, Nicole L.; Elledge, Stephen J. (2009). Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction. CELL. 136 (5): 823-837


Recommended Readings: Stephen Goff, Ph.D. Friday May 11, 2018

Friday Lectures

Friday, May 11, 2018  3:45 p.m.

Caspary Auditorium

Stephen Goff Ph.D.

Higgins Professor

Department of Biochemistry and Molecular Biophysics

Columbia University College of Physicians and Surgeons

Quiet, Please: Silencing Retroviral DNAs

Recommended Readings:

Empirical Articles

Lee, Andreia; CingOz, Oya; Sabo, Yosef; et al. (2018). Characterization of interaction between Trim28 and YY1 in silencing proviral DNA of Moloney murine leukemia virus. VIROLOGY. 516: 165-175

Geis, Franziska K.; Galla, Melanie; Hoffmann, Dirk; et al. (2017). Potent and reversible lentiviral vector restriction in murine induced pluripotent stem cells. RETROVIROLOGY. 14

Wang, Gary Z.; Goff, Stephen P. (2017). Transcriptional Silencing of Moloney Murine Leukemia Virus in Human Embryonic Carcinoma Cells. JOURNAL OF VIROLOGY. 91 (1)

Wang, Cheng; Goff, Stephen P. (2017). Differential control of retrovirus silencing in embryonic cells by proteasomal regulation of the ZFP809 retroviral repressor. PNAS. 114 (6): E922-E930

Wang, Gary Z.; Wang, Ying; Goff, Stephen P. (2016). Histones Are Rapidly Loaded onto Unintegrated Retroviral DNAs Soon after Nuclear Entry. CELL HOST MICROBE.  20 (6): 798-809

Griffin, Daniel O.; Goff, Stephen P. (2015). HIV-1 Is Restricted prior to Integration of Viral DNA in Primary Cord-Derived Human CD34(+) Cells. JOURNAL OF VIROLOGY. 89 (15): 8096-8100

Yang, Bin Xia; El Farran, Chadi A.; Guo, Hong Chao; et al. (2015). Systematic Identification of Factors for Provirus Silencing in Embryonic Stem Cells. CELL. 163 (1): 230-245

Review Paper

Schlesinger, Sharon; Goff, Stephen P. (2015). Retroviral Transcriptional Regulation and Embryonic Stem Cells: War and Peace. MOLECULAR AND CELLULAR BIOLOGY. 35 (5): 770-777

Studamire, Barbara; Goff, Stephen P. (2010). Interactions of Host Proteins with the Murine Leukemia Virus Integrase. VIRUSES. 2 (5): 1110-1145

Recommended Readings: Beth Stevens, Ph.D. Friday May 4, 2018

Friday Lectures

Friday, May 4, 2018  3:45 p.m.

Caspary Auditorium

Beth Stevens Ph.D.

Associate Professor

Department of Neurology

Harvard Medical School – Boston Children’s Hospital

How the Immune System Sculpts Brain Circuitry

Recommended Readings:

Science News

Beth Stevens and Todd E. Golden. Deciphering neurodegeneration: Inflammation, immune response, and Alzheimer’s. (Webinar – February 7, 2018). Science

Empirical Articles

Shi, Qiaoqiao; Chowdhury, Saba; Ma, Rong; et al. (2017). Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice. SCIENCE TRANSLATIONAL MEDICINE. 9 (392)

Hong, Soyon; Beja-Glasser, Victoria F.; Nfonoyim, Bianca M.; et al. (2016). Complement and microglia mediate early synapse loss in Alzheimer mouse models. SCIENCE. 352 (6286): 712-716

Vasek, Michael J.; Garber, Charise; Dorsey, Denise; et al. (2016). A complement-microglial axis drives synapse loss during virus-induced memory impairment. NATURE. 534 (7608): 538-+

Sekar, Aswin; Bialas, Allison R.; de Rivera, Heather; et al. (2016). Schizophrenia risk from complex variation of complement component 4. NATURE. 530 (7589): 177-+

Schafer, Dorothy P.; Lehrman, Emily K.; Heller, Christopher T.; et al. (2014). An Engulfment Assay: A Protocol to Assess Interactions Between CNS Phagocytes and Neurons. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 88

Schafer, Dorothy P.; Lehrman, Emily K.; Kautzman, Amanda G.; et al. (2012). Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner. NEURON. 74 (4): 691-705

Review Paper

Salter, Michael W.; Stevens, Beth. (2017). Microglia emerge as central players in brain disease. NATURE MEDICINE. 23 (9): 1018-1027

Hong, Soyon; Dissing-Olesen, Lasse; Stevens, Beth. (2016). New insights on the role of microglia in synaptic pruning in health and disease. CURRENT OPINION IN NEUROBIOLOGY. 36: 128-134  

Bilimoria, Parizad M.; Stevens, Beth. (2015). Microglia function during brain development: New insights from animal models. BRAIN RESEARCH. 1617: 7-17  

Book Chapter

Stephan, Alexander H.; Barres, Ben A.; Stevens, Beth. (2012). The Complement System: An Unexpected Role in Synaptic Pruning During Development and Disease.  ANNUAL REVIEW OF NEUROSCIENCE. 35: 369-389

Recommended Readings: David Reich, Ph.D. Friday April 27, 2018

Friday Lectures

Friday, April 27, 2018  3:45 p.m.

Caspary Auditorium

David Reich Ph.D.


Department of Genetics

Harvard Medical School

Who We Are and How We Got Here: Ancient DNA and the New Science of the Human Past

Recommended Readings:

Science News

Jared Diamond. A Brand-New Version of Our Origin Story. (April 20, 2018). The New York Times

Robin McKie. Neanderthals were perhaps capable of many modern human behaviours. (April 7, 2018). The Guardian

Turi King. Sex, power and ancient DNA. (March 13, 2018). Nature

Empirical Articles

Loreille, Odile ; Ratnayake, Shashikala ; Bazinet, Adam L.; et al. (2018). Biological Sexing of a 4000-Year-Old Egyptian Mummy Head to Assess the Potential of Nuclear DNA Recovery from the Most Damaged and Limited Forensic Specimens. GENES. 9 (3): 135

Olalde, Inigo; Brace, Selina; Allentoft, Morten E.; et al. (2018). The Beaker phenomenon and the genomic transformation of northwest Europe. NATURE. 555 (7695): 190-196

Mathieson, Iain; Alpaslan-Roodenberg, Songul; Posth, Cosimo; et al. (2018). The genomic history of southeastern Europe. NATURE. 555 (7695): 197-203

Hajdinjak, Mateja; Fu, Qiaomei; Huebner, Alexander; et al. (2018). Reconstructing the genetic history of late Neanderthals. NATURE. 555 (7698): 652-656

Lipson, Mark; Skoglund, Pontus; Spriggs, Matthew; et al. (2018). Population Turnover in Remote Oceania Shortly after Initial Settlement. CURRENT BIOLOGY. 28 (7): 1157-+

Palkopoulou, Eleftheria; Lipson, Mark; Mallick, Swapan; et al. (2018). A comprehensive genomic history of extinct and living elephants. PNAS. 115 (11): E2566-E2574

Tassi, Francesca; Vai, Stefania; Ghirotto, Silvia; et al. (2017). Genome diversity in the Neolithic Globular Amphorae culture and the spread of Indo-European languages. PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES. 284 (1867

Haak, Wolfgang; Lazaridis, Iosif; Patterson, Nick; et al. (2015). Massive migration from the steppe was a source for Indo-European languages in Europe. NATURE. 522 (7555): 207-+

Altshuler, David M.; Durbin, Richard M.; Abecasis, Goncalo R.; et al. (2012). An integrated map of genetic variation from 1,092 human genomes. NATURE. 491 (7422): 56-65

Review Paper

Pickrell, Joseph K.; Reich, David. (2014). Toward a new history and geography of human genes informed by ancient DNA. TRENDS IN GENETICS.  30 (9): 377-389


David Reich, Who We Are and How We Got Here: Ancient DNA and the New Science of the Human Past (Pantheon Books, New York, and Oxford University Press, Oxford, 2018)

Recommended Readings: Gabriel D. Victora, Ph.D., Monday April 23, 2018

Monday Lectures

Monday, April 23, 2018  4:00 p.m.

Carson Family Auditorium

Gabriel D. Victora, Ph.D.

Laurie and Peter Grauer Assistant Professor and Head

Laboratory of Lymphocyte Dynamics

The Rockefeller University

Clonal and Cellular Dynamics of Antibody Evolution

Recommended Readings:

Science News

New tool for tracking ‘kiss-and-run’ communication between cells. January 30, 2018. ScienceDaily

Empirical Articles

Pasqual G, Chudnovskiy A, Tas JMJ, Agudelo M, Schweitzer LD, Cui A, Hacohen N, Victora GD. (2018). Monitoring T cell-dendritic cell interactions in vivo by intercellular enzymatic labelling. NATURE. 553 (7689): 496-500

Degn, Soren E.; van der Poel, Cees E.; Firl, Daniel J.; et al. (2017). Clonal Evolution of Autoreactive Germinal Centers. CELL. 170 (5): 913-+

Ersching, Jonatan; Efeyan, Alejo; Mesin, Luka; et al. (2017). Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase. IMMUNITY. 46 (6): 1045-+

Amitai, Assaf; Mesin, Luka; Victora, Gabriel D.; et al. (2017). A Population Dynamics Model for Clonal Diversity in a Germinal Center. FRONTIERS IN MICROBIOLOGY. 8  

Tas, Jeroen M. J.; Mesin, Luka; Pasqual, Giulia; et al. (2016). Visualizing antibody affinity maturation in germinal centers. SCIENCE. 351 (6277): 1048-1054

Shulman, Ziv; Gitlin, Alexander D.; Targ, Sasha; et al. (2013). T Follicular Helper Cell Dynamics in Germinal Centers. SCIENCE. 341 (6146): 673-677

Victora, Gabriel D.; Dominguez-Sola, David; Holmes, Antony B.; et al. (2012). Identification of human germinal center light and dark zone cells and their relationship to human B-cell lymphomas. BLOOD. 120 (11): 2240-2248

Victora, Gabriel D.; Schwickert, Tanja A.; Fooksman, David R.; et al. (2010). Germinal Center Dynamics Revealed by Multiphoton Microscopy with a Photoactivatable Fluorescent Reporter. CELL. 143 (4): 592-605

Review Papers

Mesin, Luka; Ersching, Jonatan; Victora, Gabriel D. (2016). Germinal Center B Cell Dynamics. IMMUNITY. 45 (3): 471-482

Victora, Gabriel D.; Wilson, Patrick C. (2015). Germinal Center Selection and the Antibody Response to Influenza. CELL. 163 (3): 545-548

Victora, Gabriel D.; Mesin, Luka. (2014). Clonal and cellular dynamics in germinal centers. CURRENT OPINION IN IMMUNOLOGY. 28: 90-96 

Book Chapter

Victora, Gabriel D.; Nussenzweig, Michel C. (2012). Germinal Centers. ANNUAL REVIEW OF IMMUNOLOGY. 30: 429-457    

Recommended Readings: Shai Shaham, Ph.D., Monday April 16, 2018

Monday Lectures

Monday, April 16, 2018  4:00 p.m.

Carson Family Auditorium

Shai Shaham, Ph.D.

Richard E. Salomon Family Professor and Head

Laboratory of Developmental Genetics

The Rockefeller University

Uncovering Cell Death Treasure Hiding in Plain Sight

Recommended Readings:

Science News

Brandon Specktor. See How a Single Cell Dies in Gory, Intricate Detail. (March 28, 2018). Live Science

Empirical Articles

Ghose P, Rashid A, Insley P, Trivedi M, Shah P, Singhal A, Lu Y, Bao Z, Shaham S. (2018). EFF-1 fusogen promotes phagosome sealing during cell process clearance in Caenorhabditis elegans. NATURE CELL BIOLOGY. 20 (4):393-399

Malin, Jennifer A.; Kinet, Maxime J.; Abraham, Mary C.; et al. (2016). Transcriptional control of non-apoptotic developmental cell death in C-elegans. CELL DEATH AND DIFFERENTIATION. 23 (12): 1985-1994

Schwendeman, Andrew R.; Shaham, Shai. (2016). A High-Throughput Small Molecule Screen for C-elegans Linker Cell Death Inhibitors. PLOS ONE. 11 (10) 

Kinet, Maxime J.; Malin, Jennifer A.; Abraham, Mary C.; et al. (2016). HSF-1 activates the ubiquitin proteasome system to promote non-apoptotic developmental cell death in C. elegans. ELIFE. 5

Blum, Elyse S.; Abraham, Mary C.; Yoshimura, Satoshi; et al. (2012). Control of Nonapoptotic Developmental Cell Death in Caenorhabditis elegans by a Polyglutamine-Repeat Protein. SCIENCE. 335 (6071): 970-973

Review Papers

Kutscher, Lena M.; Shaham, Shai (2017). Non-apoptotic cell death in animal development. CELL DEATH AND DIFFERENTIATION. 24 (8): 1326-1336

Blum, Elyse S.; Schwendeman, Andrew R.; Shaham, Shai. (2013). PolyQ disease: misfiring of a developmental cell death program? TRENDS IN CELL BIOLOGY. 23 (4): 168-174  

Book Chapters

Malin, Jennifer Zuckerman; Shaham, Shai. (2015). Cell Death in C. elegans Development. CURRENT TOPICS IN DEVELOPMENTAL BIOLOGY. 114: 1-42

Kinet, Maxime J.; Shaham, Shai. (2014). Noncanonical Cell Death in the Nematode Caenorhabditis elegans. METHODS IN ENZYMOLOGY. 545: 157-180


Recommended Readings: Daniel Kronauer, Ph.D. Monday April 9, 2018

Monday Lectures

Monday, April 9, 2018  4:00 p.m.

Caspary Auditorium

Daniel Kronauer, Ph.D.

Stanley S. and Sydney R. Shuman Associate Professor and Head

Laboratory of Social Evolution and Behavior

The Rockefeller University

The Evolution of Eusociality in Ants

Recommended Readings:

Science News

Substance that guides ant trail is produced by symbiotic bacteria. April 9, 2018. ScienceDaily

Empirical Articles

von Beeren, Christoph; Brueckner, Adrian; Maruyama, Munetoshi; et al. (2018). Chemical and behavioral integration of army ant-associated rove beetles – a comparison between specialists and generalists. FRONTIERS IN ZOOLOGY. 15

Ulrich, Yuko; Burns, Dominic; Libbrecht, Romain; et al. (2016). Ant larvae regulate worker foraging behavior and ovarian activity in a dose-dependent manner. BEHAVIORAL ECOLOGY AND SOCIOBIOLOGY. 70 (7): 1011-1018

Libbrecht, Romain; Oxley, Peter Robert; Keller, Laurent; et al. (2016). Robust DNA Methylation in the Clonal Raider Ant Brain. CURRENT BIOLOGY. 26 (3): 391-395

Oxley, Peter R.; Ji, Lu; Fetter-Pruneda, Ingrid; et al. (2014). The Genome of the Clonal Raider Ant Cerapachys biroi. CURRENT BIOLOGY. 24 (4): 451-458

Abbot, Patrick; Abe, Jun; Alcock, John; et al. (2011). Inclusive fitness theory and eusociality. NATURE. 471 (7339): E1-E4  

Review Papers

Trible, Waring; Kronauer, Daniel J. C. (2017). Caste development and evolution in ants: it’s all about size. JOURNAL OF EXPERIMENTAL BIOLOGY. 220 (1): 53-62

Libbrecht, Romain; Oxley, Peter R.; Kronauer, Daniel J. C.; et al. (2013). Ant genomics sheds light on the molecular regulation of social organization. GENOME BIOLOGY. 14 (7)

Book Chapter

Ivens, Aniek B. F.; von Beeren, Christoph; Bluethgen, Nico; et al. (2016). Studying the Complex Communities of Ants and Their Symbionts Using Ecological Network Analysis. ANNUAL REVIEW OF ENTOMOLOGY. 6: 353-+


Recommended Readings: Clare Waterman, Ph.D. Friday April 6, 2018

Friday Lectures

Friday, April 6, 2018  3:45 p.m.

Caspary Auditorium

Clare Waterman Ph.D.

NIH Distinguished Investigator

Laboratory of Cell and Tissue Morphodynamics

National Institutes of Health

Integrating Actin Dynamics and Adhesion in Cell Migration and Immune Function

Recommended Readings:

Science News

Live-Cell Microscopy Reveals How Cell Movement is Driven. Dec 11, 2017. GEN News

Empirical Articles

Nordenfelt, Pontus; Moore, Travis I.; Mehta, Shalin B.; et al. (2017). Direction of actin flow dictates integrin LFA-1 orientation during leukocyte migration. NATURE COMMUNCATIONS. 8

Swaminathan, Vinay; Kalappurakkal, Joseph Mathew; Mehta, Shalin B.; et al. (2017). Actin retrograde flow actively aligns and orients ligand-engaged integrins in focal adhesions. PNAS. 114 (40): 10648-10653

Wu, Yicong; Chandris, Panagiotis; Winter, Peter W.; et al. (2016). Simultaneous multiview capture and fusion improves spatial resolution in wide-field and light-sheet microscopy. OPTICA. 3 (8): 897-910

Plotnikov, Sergey V.; Pasapera, Ana M.; Sabass, Benedikt; et al. (2012). Force Fluctuations within Focal Adhesions Mediate ECM-Rigidity Sensing to Guide Directed Cell Migration. CELL. 151 (7): 1513-1527

Kanchanawong, Pakorn; Shtengel, Gleb; Pasapera, Ana M.; et al. (2010). Nanoscale architecture of integrin-based cell adhesions. NATURE. 468 (7323): 580-U262

Review Paper

Case, Lindsay B.; Waterman, Clare M. (2015). Integration of actin dynamics and cell adhesion by a three-dimensional, mechanosensitive molecular clutch. NATURE CELL BIOLOGY. 17 (8): 955-963

Fischer, Robert S.; Wu, Yicong; Kanchanawong, Pakorn; et al. (2011). Microscopy in 3D: a biologist’s toolbox. TRENDS IN CELL BIOLOGY. 21 (12): 682-691

Book Chapter

Skau, Colleen T.; Waterman, Clare M. (2015). Specification of Architecture and Function of Actin Structures by Actin Nucleation Factors. ANNUAL REVIEW OF BIOPHYSICS. 44: 285-310

Gardel, Margaret L.; Schneider, Ian C.; Aratyn-Schaus, Yvonne; et al. (2010). Mechanical Integration of Actin and Adhesion Dynamics in Cell Migration. ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY. 26: 315-333