Recommended Readings: Christopher T. Walsh, Ph.D.

Friday Lecture Series

Peptide-based Natural Antibiotics Strategies for Scaffold Transformation

 Christopher T. Walsh, Ph.D.

Hamilton Kuhn Professor, Department of Biological Chemsitry and Molecular Pharmacology

Harvard Medical School

Friday, February 20, 2009

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Articles:

Nolan EM, Walsh CT. 2009.  How Nature Morphs Peptide Scaffolds into Antibiotics
CHEMBIOCHEM   10(1 ):34-53   


Magarvey NA, Fortin PD, Thomas PM, et al.  2008. Gatekeeping versus promiscuity in the early stages of the andrimid biosynthetic assembly line. ACS CHEMICAL BIOLOGY  3(9):542-554   


Roege KE, Kelly WL. 2009. Biosynthetic Origins of the Ionophore Antibiotic Indanomycin.  ORGANIC LETTERS   11(2): 297-300   


Bumpus SB, Kelleher NL.  2008.  Accessing natural product biosynthetic processes by mass spectrometry.  CURRENT OPINION IN CHEMICAL BIOLOGY . 12(5): 475-482   


Watanabe K.  2008.  Exploring the Biosynthesis of Natural Products and Their Inherent Suitability for the Rational Design of Desirable Compounds through Genetic Engineering. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY   72(10):2491-2506   


Howard-Jones AR, Kruger RG, Lu W, et al.. 2007.   Kinetic analysis of teicoplanin glycosyltransferases and acyltransferase reveal ordered tailoring of aglycone scaffold to reconstitute mature teicoplanin.  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 129(33):10082-+   


La Clair JJ .  2006.  Cellular routines in the synthesis of cyclic peptide probes. TETRAHEDRON   62(22):5347-5354


Kruger RG, Lu W, Oberthur M, et al. 2005. Tailoring of glycopeptide scaffolds by the acyltransferases from the teicoplanin and A-40,926 biosynthetic operons.  CHEMISTRY & BIOLOGY   12(1):131-140  


Gruenewald S, Mootz HD, Stehmeier P, et al.   2004.  In vivo production of artificial nonribosomal peptide products in the heterologous host Escherichia coli.  APPLIED AND ENVIRONMENTAL MICROBIOLOGY    70(6): 3282-3291