Recommended Readings: Kivanç Birsoy, Ph.D. Monday May 20, 2019

Monday Lectures

Monday, May 20, 2019  4:00 p.m.

Carson Family Auditorium

Kivanç Birsoy, Ph.D.

Chapman Perelman Assistant Professor and Head

Laboratory of Metabolic Regulation and Genetics

The Rockefeller University

Metabolic Limitations of Cancer Cell Proliferation


Recommended Readings:

Science News

Oxygen-Starved Cancer Cells Languish without Aspartate. Jun 25, 2018. Genetic Engineering & Biotechnology News

Empirical Articles

Garcia-Bermudez, Javier; Baudrier, Lou; Bayraktar, Erol Can; et al. (2019). Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death. NATURE. 567 (7746): 118-+

Phillips, Richard E.; Yang, Yanhong; Smith, Ryan C.; et al. (2019). Target identification reveals lanosterol synthase as a vulnerability in glioma. PNAS. 116 (16): 7957-7962

Bayraktar, Erol C.; Baudrier, Lou; Ozerdem, Ceren; et al. (2019). MITO-Tag Mice enable rapid isolation and multimodal profiling of mitochondria from specific cell types in vivo. PNAS. 116  (1) : 303-312

Garcia-Bermudez, Javier; Baudrier, Lou; La, Konnor; et al. (2018). Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours. NATURE CELL BIOLOGY. 20 (7): 775-+

Peng, Xinxin; Chen, Zhongyuan; Farshidfar, Farshad; et al. (2018). Molecular Characterization and Clinical Relevance of Metabolic Expression Subtypes in Human Cancers. CELL REPORTS. 23 (1): 255-+

Reczek, Colleen R.; Birsoy, Kivanc; Kong, Hyewon; et al. (2017). A CRISPR screen identifies a pathway required for paraquat-induced cell death. NATURE CHEMICAL BIOLOGY. 13 (12): 1274-+

Chen, Walter W.; Freinkman, Elizaveta; Wang, Tim; et al. (2016). Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism. CELL. 166 (5): 1324-+