Recommended Readings: George R. Stark, Ph.D. Friday May 10, 2019

Friday Lectures

Friday, May 10, 2019  3:45 p.m

Caspary Auditorium

George R. Stark Ph.D.

Distinguished Scientist

Department of Cancer Biology

Lerner Research Institute, Cleveland Clinic


Complex Regulation of Interferon-dependent Signaling in Cancer and Infectious Disease


Recommended Readings:

Science News

Promising New Combination Drug Therapy Treats Several Models of Lethal Lung Cancer. March 1, 2018. Cleveland Clinic

Empirical Articles

Banerjee, Shuvojit; Gusho, Elona; Gaughan, Christina; et al. (2019). OAS-RNase L innate immune pathway mediates the cytotoxicity of a DNA-demethylating drug. PNAS. 116 (11): 5071-5076

Nan, Jing; Wang, Yuxin; Yang, Jinbo; et al. (2018). IRF9 and unphosphorylated STAT2 cooperate with NF-kappa B to drive IL6 expression. PNAS. 115 (15): 3906-3911

Stark, George R.; Cheon, HyeonJoo; Wang, Yuxin. (2018). Responses to Cytokines and Interferons that Depend upon JAKs and STATs. COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY. 10 (1)

Wang, Yuxin; Nan, Jing; Willard, Belinda; et al. (2017). Negative regulation of type I IFN signaling by phosphorylation of STAT2 on T387. EMBO JOURNAL. 36 (2): 202-212

Cheon, HyeonJoo; Holvey-Bates, Elise G.; Schoggins, John W.; et al. (2013). IFN beta-dependent increases in STAT1, STAT2, and IRF9 mediate resistance to viruses and DNA damage. EMBO JOURNAL. 32 (20): 2751-2763

Review Papers

Cheon, HyeonJoo; Borden, Ernest C.; Stark, George R. (2014). Interferons and Their Stimulated Genes in the Tumor Microenvironment. SEMINARS IN ONCOLOGY. 41 (2): 156-173

Stark, George R.; Darnell, James E., Jr. (2012). The JAK-STAT Pathway at Twenty. IMMUNITY. 36 (4): 503-514

Cheon, HyeonJoo; Yang, Jinbo; Stark, George R. (2011). The Functions of Signal Transducers and Activators of Transcriptions 1 and 3 as Cytokine-Inducible Proteins. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH. 31 (1): 33-40

Book Chapter

Lu, Tao; Stark, George R. (2015). Using Sequential Immunoprecipitation and Mass Spectrometry to Identify Methylation of NF-kappa B. NF-KAPPA B: METHODS AND PROTOCOLS. 1280: 383-393