Recommended Readings: Michael Lenardo, M.D., October 23rd

Friday Lecture Series
Friday, October 23, 2015
3:45 p.m., Caspary Auditorium

Michael Lenardo, M.D.
Chief, Molecular Development Section,
Laboratory of Immunology,
Director, NIAID Clinical Genomics Program,
National Institute of Allergy and Infectious Diseases,
National Institutes of Health

Genomic Approaches to Solving Primary Immune Disorders

Recommended Readings

Empirical Articles

Kuehn, H. S., Ouyang, W., Lo, B., Deenick, E. K., Niemela, J. E., Avery, D. T., … & Uzel, G. (2014). Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4. Science, 345(6204), 1623-1627. doi:10.1126/science.1255904.

Lo, B., Zhang, K., Lu, W., Zheng, L., Zhang, Q., Kanellopoulou, C., … & Jordan, M. B. (2015). Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy. Science, 349(6246), 436-440. doi:10.1126/science.aaa1663.

Lucas, C. L., Zhang, Y., Venida, A., Wang, Y., Hughes, J., McElwee, J., … & Lenardo, M. J. (2014). Heterozygous splice mutation in PIK3R1 causes human immunodeficiency with lymphoproliferation due to dominant activation of PI3K. The Journal of Experimental Medicine, 211(13), 2537-2547. doi:10.1084/jem.20141759.

Review Papers

Grönholm, J., & Lenardo, M. J. (2015). Novel diagnostic and therapeutic approaches for autoimmune diabetes- A prime time to treat insulitis as a disease. Clinical Immunology, 156(2), 109-118. doi:10.1016/j.clim.2014.11.007.

Zhang, Y., Su, H. C., & Lenardo, M. J. (2015). Genomics is rapidly advancing precision medicine for immunological disorders. Nature Immunology, 16(10), 1001-1004. doi:10.1038/ni.3275