Recommended Readings: Titia de Lange, Ph.D.

Friday Lecture Series

Breaking Bad: How Telomeres Hide from the DNA Damage Response

Titia de Lange, Ph.D., Leon Hess Professor, Head of the Laboratory of Cell Biology and Genetics, The Rockefeller University

February 28, 2014

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Davoli, T., Denchi, E. L., & de Lange, T. (2010). Persistent telomere damage induces bypass of mitosis and tetraploidy. Cell, 141(1), 81-93

Hockemeyer, D., Sfeir, A. J., Shay, J. W., Wright, W. E., & De Lange, T. (2005). POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end. EMBO Journal, 24(14), 2667-2678

Jacobs, J. J. L., & De Lange, T. (2005). p16INK4a as a second effector of the telomere damage pathway. Cell Cycle, 4(10), 1364-1368

Konishi, A., & De Lange, T. (2008). Cell cycle control of telomere protection and NHEJ revealed by a ts mutation in the DNA-binding domain of TRF2. Genes and Development, 22(9), 1221-1230

Sfeir, A., & De Lange, T. (2012). Removal of shelterin reveals the telomere end-protection problem. Science, 336(6081), 593-597

Sfeir, A., Kabir, S., Van Overbeek, M., Celli, G. B., & De Lange, T. (2010). Loss of Rap1 induces telomere recombination in the absence of NHEJ or a DNA damage signal. Science, 327(5973), 1657-1661

Wu, P., Takai, H., & De Lange, T. (2012). Telomeric 3′ overhangs derive from resection by Exo1 and apollo and fill-in by POT1b-associated CST. Cell, 150(1), 39-52