Related Readings – Satinder Kaur Singh, Ph.D.

Antidepressant Binding Site in a Bacterial Homologue of Neurotransmitter Transporters

Tuesday, February 19, 2008
Welch Hall (2nd Floor)

3:45 p.m. Refreshments 4:00 p.m. Lecture

Figure 3 from Singh et al. (2007) Nature 448:952-956.

Figure 3. Clomipramine-binding site. From Singh at al. (2007) Nature 448:952-956.

Recommended Review Article

Gether, U., Andersen, P. H., Larsson, O. M. and Schousboe, A. (2006). Neurotransmitter transporters: molecular function of important drug targets. Trends in Pharmacological Sciences 27:375-383.

Related Articles

Rudnick, G. (2007). What is an antidepressant binding site doing in a bacterial transporter? ACS Chemical Biology 2:606-609.
Singh, S. K., Yamashita, A. and Gouaux, E. (2007). Antidepressant binding site in a bacterial homologue of neurotransmitter transporters. Nature 448:952-956.
Yamashita, A., Singh, S. K., Kawate, T., Jin, Y. and Gouaux, E. (2005). Crystal structure of a bacterial homologue of Na+/Cl–dependent neurotransmitter transporters. Nature 437:215-223.
Zhou, Z., Zhen, J., Karpowich, N. K., Goetz, R. M., Law, C. J., Reith, M. E. A. and Wang, D. N. (2007). LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake. Science 317:1390-1393.