ScienceDaily February 10, 2013. National Institutes of Health (NIH) scientists have identified a promising lead for developing a new type of drug to treat infection caused by Staphylococcus aureus, notable drug-resistant pathogen. They have discovered a transport system for toxins that are thought to contribute to severe staph infections – phenol-soluble modulins (PSMs). The transport system, Pmt, is common to all S. aureus PSMs and critical for bacterial proliferation and disease development in a mouse model. Their experiments suggest that a drug interfering with Pmt’s function could not only prevent production of the PSM toxins, but also directly lead to bacterial death. This research is reported in Nature Medicine.
adaptive immunity Alzheimer's Disease antibiotics apoptosis bacteria Breast cancer C. elegans Caenorhabditis elegans cancer chromatin circadian clocks CRISPR cryo-electron microscopy DNA dopamine Drosophila Epigenetics eukaryotes evolution gene expression Genomics histones HIV HIV AIDS human genome immunity metabolism microRNA miRNA mitochondria mRNA neural circuits neurodegeneration neurons obesity optogenetics Parkinson's Disease pathogenesis proteomics ribosomes RNA stem cells synapses transcription vaccines