Crystallographic Studies of Large Complexes: From the Yeast Chromatin

Remodeling Factor ISW1a to the Entire Nucleosome-Traversing

Transcription Machinery

Kazuhiro Yamada,  PhD

Senior Scientist/Over-assistant

Institute of Molecular Biology and Biophysics

ETH Zurich

Monday, October 1, 2012

4 p.m. , Caspary Auditorium.   Refreshments 3:45 p.m.

 Recommended Readings:

Yen, K.; Vinayachandran, V.; Batta, K.; et al.   2012. Genome-wide Nucleosome Specificity and Directionality of Chromatin Remodelers.  CELL   149(7):1461-1473   DOI: 10.1016/j.cell.2012.04.036

Richmond, Timothy J.  2012. Nucleosome recognition and spacing by chromatin remodelling factor ISW1a.   BIOCHEMICAL SOCIETY TRANSACTIONS,  40: 347-350  DOI: 10.1042/BST20110748   Please request from Markus Library.

De Cian, A; Praly, E; Ding, F; et al.  2012.  ATP-Independent Cooperative Binding of Yeast Isw1a to Bare and Nucleosomal DNA.    PLOS ONE   7(2): e31845   DOI: 10.1371/journal.pone.0031845

Sharma, A.; Jenkins, K. R.; Heroux, A.; et al.  2011. Crystal Structure of the Chromodomain Helicase DNA-binding Protein 1 (Chd1) DNA-binding Domain in Complex with DNA.  JOURNAL OF BIOLOGICAL CHEMISTRY    286(49):42099-42104   DOI: 10.1074/jbc.C111.294462

Yamada, K.; Frouws, T. D.; Angst, B.; et al. 2011.  Structure and mechanism of the chromatin remodelling factor ISW1a.   NATURE.  472(7344):U448-U536   DOI: 10.1038/nature09947

Pinskaya, M.; Nair, A.; Clynes, D.; et al.  2009.  Nucleosome Remodeling and Transcriptional Repression Are Distinct Functions of Isw1 in Saccharomyces cerevisiae.  MOLECULAR AND CELLULAR BIOLOGY   29(9): 2419-2430   DOI: 10.1128/MCB.01050-08