Master Control Switch for Breast Cancer Oncogene Discovered

Scientists have discovered an accomplice in breast cancer — a master control switch with the power to set off a cascade of reactions orchestrated by anĀ oncogene named Wnt1. This executive molecule and its modus operandi are reported in back-to-back papers featured on the cover of the August 15 issue of Cancer Research.

Metastasis-Associated Protein 1 Short Form Stimulates Wnt1 Pathway in Mammary Epithelial and Cancer Cells

Metastasis-Associated Protein 1 and Its Short Form Variant Stimulates Wnt1 Transcription through Promoting Its Derepression from Six3 Corepressor