Recommended Readings: Dennis W. Wolan, Ph.D. Jan 25, 2010

Monday Lecture Series

Directed Small Molecule Activation of Apoptotic Procaspases

Dennis W. Wolan, Ph.D.,

Post Doctoral Fellow, Department of Pharmaceutical Chemistry

University of California, San Francisco

January 25, 2010

Welch Hall,  Level Two

4:00p.m.-5:00 p.m

Recommended Articles:

Wolan DW, Zorn JA, Gray DC, et al.  2009.  Small-Molecule Activators of a Proenzyme SCIENCE 326( 5954): 853-858

Eisenstein M.  2010.  Caught in action. NATURE METHODS 7(1): 12-12

Chereau D, Zou H, Spada AP, et al.  2005.  A nucleotide binding site in caspase-9 regulates apoptosome activation.    BIOCHEMISTRY 44(13): 4971-4976

Wu JM, Gorman A, Zhou XH, et al.  2002.  Involvement of caspase-3 in photoreceptor cell apoptosis induced by in vivo blue light exposure. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 43(10): 3349-3354

Henzing AJ, Dodson H, Reid JM, et al.   2006.  Synthesis of novel caspase inhibitors for characterization of the active caspase proteome in vitro and in vivo .    JOURNAL OF MEDICINAL CHEMISTRY 49(26):7636-7645

Denault JB;  Drag M.;  Salvesen GS;  Alves J;  Heidt AB; Deveraux Q ; Harris JL .  2007.  Small molecules not direct activators of caspases. NATURE CHEMICAL BIOLOGY 3(9): 519-519

BOATRIGHT KM; Salveson GS.  2003.  Mechanisms of caspase activation. CURRENT OPINION IN CELL BIOLOGY 15: 725

BLANC C.  2000.  Caspase-3 is essential for procaspase-9 processing and cisplatin-induced apoptosis of MCF-7 breast cancer cells. CANCER RESEARCH 60 : 4386-4390