Recommended Readings: Luciano Marraffini, Ph.D. Jan 11, 2010

Monday Lecture Series

Self vs Non-self Discrimination During CRISPR Immunity

Against Horizontal Gene Transfer

Luciano Marraffini, Ph.D.,

Post Doctoral Fellow, Department of Biochemistry, Molecular Biology and Cell Biology

Northwestern University

January 11, 2010

4:00p.m.-5:00 p.m.

Welch Hall, Level Two

Recommended readings:

Van der Oost, J; Jore, MM; Westra, ER; et al.  2009.  CRISPR-based adaptive and heritable immunity in prokaryotesTrends in biochemical sciences  34(8):401-407

Agari, Y; Yokoyama, S; Kuramitse, S; Shinkai, A.  2008.  X-ray crystal stryctyre of a CRISPR-associated protein, CSe2, from Thermus themaphilus, HB8.  Proteins – Structure Function and bioinformatics  73(4):1063-1067

Horvath, P; Romero, DA; Coute-Monvoison, AC; Richards, M; et al.  2008.  Diversity, activity, and evolution of CRISPR loci in Streptococcus thermophilus.  Journal of bacteriology  1990(4):1401-1412

Brouns, SJJ; Jore,MM; Lundgren, M; Westra R; et al.  2008   Small CRISPR RNAs guide antiviral defense in prokaryotes.   SCIENCE  321(5891): 960-964 

Barrangou, RF; Fremaux, C; Deveau, H; Richards, M; Boyaval, P; Moineau, S; RFomero, DA; Horvath, P.  2007.  CRISPR provides acquired resistance against viruses in prokaryotes.  SCIENCE  315(5819):1709-1712

Tesch, LD; Raghavendra, MP; Bedsted-Faarvang, T; et al.  2005.  Specificity and reactive loop length requirements for cmA inhibition of serine proteases.  Protein science  14(2):533-542

Beloglazona, N; Brown, G; Zimmerman, MD; Proudfoot, M; Marakova, KS; et al.  2008.  A novel family of sequence-specific endoribonucleases associated with the clustered regularly interspaced short palindromic repeats.  Journal of biological chemistry.  283(29): 20361-20371