Recommended Readings: Michael W. Young, Ph.D., Monday October 8, 2018

Monday Lectures

Monday, October 8, 2018  4:00 p.m.

Carson Family Auditorium

Michael W. Young, Ph.D.

Richard and Jeanne Fisher Professor and Head

Laboratory of Genetics

The Rockefeller University

Genes Controlling Sleep and Circadian Rhythms

Recommended Readings:

Science News

Rosemary Braun. A Simple Blood Test Could Tell You the Time Inside Your Body. September 12, 2018. Discover Magazine

Empirical Articles

Young, Michael W. (2018). Time Travels: A 40-Year Journey from Drosophila’s Clock Mutants to Human Circadian Disorders (Nobel Lecture).  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 57 (36): 11532-11539

Top, Deniz; Young, Michael W. (2018). Coordination between Differentially Regulated Circadian Clocks Generates Rhythmic Behavior. COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY. 10 (7)

Lin, Changfan; Top, Deniz; Manahan, Craig C.; et al. (2018). Circadian clock activity of cryptochrome relies on tryptophan-mediated photoreduction. PNAS. 115 (15): 3822-3827

Top, Deniz; O’Neil, Jenna L.; Merz, Gregory E.; et al. (2018). CK1/Doubletime activity delays transcription activation in the circadian clock. ELIFE. 7

Patke, Alina; Murphy, Patricia J.; Onat, Onur Emre; et al. (2017). Mutation of the Human Circadian Clock Gene CRY1 in Familial Delayed Sleep Phase Disorder. CELL.  169 (2): 203-215

Rogulja, Dragana; Young, Michael W. (2012). Control of Sleep by Cyclin A and Its Regulator. SCIENCE. 335 (6076): 1617-1621  

Zoltowski, Brian D.; Vaidya, Anand T.; Top, Deniz; et al. (2011). Structure of full-length Drosophila cryptochrome. NATURE. 480 (7377): 396-U156

Review Papers

Wijnen, Herman; Naef, Felix; Boothroyd, Catharine; et al. (2006). Control of daily transcript oscillations in Drosophila by light and the circadian clock. PLOS GENETICS. 2 (3): 326-343

Book Chapter

Axelrod, Sofia; Saez, Lino; Young, Michael W. (2015). Studying Circadian Rhythm and Sleep Using Genetic Screens in Drosophila. METHODS IN ENZIMOLOGY. 551: 3-27  

Crane, Brian R.; Young, Michael W. (2014). Interactive Features of Proteins Composing Eukaryotic Circadian Clocks. ANNUAL REVIEW OF BIOCHEMISTRY. 83: 191-219

Recommended Readings: Peter Reddien, Ph.D. Friday September 28, 2018

Friday Lectures

Friday, September 28, 2018  3:45 p.m.

Caspary Auditorium

Peter Reddien Ph.D.

Professor and Associate Department Head

Department of Biology

Massachusetts Institute of Technology

How Stem Cells and Positional Information Lead to Planarian Regeneration

Recommended Readings:

Science News

Lisa Girard. A blueprint for regeneration. March 15, 2018. MIT News

Empirical Articles

Fincher, Christopher T.; Wurtzel, Omri; de Hoog, Thom; et al. (2018). Cell type transcriptome atlas for the planarian Schmidtea mediterranea. SCIENCE.  360 (6391): 874-+

Atabay KD, LoCascio SA, de Hoog T, Reddien PW. (2018). Self-organization and progenitor targeting generate stable patterns in planarian regeneration. SCIENCE. 360 (6387):404-409

Scimone, M. Lucila; Cote, Lauren E.; Reddien, Peter W. (2017). Orthogonal muscle fibres have different instructive roles in planarian regeneration. NATURE. 551 (7682): 623-+  

Raz, Amelie A.; Srivastava, Mansi; Salvamoser, Ranja; et al. (2017). Acoel regeneration mechanisms indicate an ancient role for muscle in regenerative patterning. NATURE COMMUNCATIONS. 8

Wurtzel, Omri; Oderberg, Isaac M.; Reddien, Peter W. (2017). Planarian Epidermal Stem Cells Respond to Positional Cues to Promote Cell-Type Diversity. DEVELOPMENTAL CELL. 40 (5): 491-504  

Scimone, M. Lucila; Kravarik, Kellie M.; Lapan, Sylvain W.; et al. (2014). Neoblast Specialization in Regeneration of the Planarian Schmidtea mediterranea. STEM CELLS REPORTS. 3 (2): 339-352

van Wolfswinkel, Josien C.; Wagner, Daniel E.; Reddien, Peter W. (2014). Single-Cell Analysis Reveals Functionally Distinct Classes within the Planarian Stem Cell Compartment. CELL STEM CELL. 15 (3): 326-339

Wagner, Daniel E.; Wang, Irving E.; Reddien, Peter W. (2011). Clonogenic Neoblasts Are Pluripotent Adult Stem Cells That Underlie Planarian Regeneration. SCIENCE. 332 (6031): 811-816  

Review Paper

Tanaka, Elly M.; Reddien, Peter W. (2011). The Cellular Basis for Animal Regeneration. DEVELOPMENTAL CELL. 21 (1): 172-185

Reddien, Peter W. (2011). Constitutive gene expression and the specification of tissue identity in adult planarian biology.  TRENDS IN GENETICS. 27 (7): 277-285  

Book Chapter

Wang IE, Wagner DE, Reddien PW. (2018). Clonal Analysis of Planarian Stem Cells by Subtotal Irradiation and Single-Cell Transplantation. Planarian Regeneration. 1774:479-495

Recommended Readings: John Hardy, Ph.D. Friday September 7, 2018

Friday Lectures

Friday, September 7, 2018  3:45 p.m.

Caspary Auditorium

John Hardy Ph.D.

Head of the Department of Molecular Neuroscience

Chair of the Molecular Biology of Neurological Disease

University College London

Genomic Analysis of Alzheimer’s Disease and other Neurodegenerative Disorders

Recommended Readings:

Science News

Rebecca Hiscott. AT THE BENCH: John Hardy, PhD, on Unraveling the Genetics of Alzheimer’s Disease and Attending the ‘Oscars of Science’. January 7, 2016. Neurology Today

Enter the New Alzheimer’s Gene: TREM2 Variant Triples Risk. November 14, 2012. ALZFORUM

Empirical Articles

Karch, Celeste M.; Wen, Natalie; Fan, Chun C.; et al. (2018). Selective Genetic Overlap Between Amyotrophic Lateral Sclerosis and Diseases of the Frontotemporal Dementia Spectrum. JAMA NEUROLOGY. 75 (7)860-875 

Sims, Rebecca; van der Lee, Sven J.; Naj, Adam C.; et al. (2017). Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer’s disease. NATURE GENETICS. 49 (9)1373-+ 

Wang, Yaming; Cella, Marina; Mallinson, Kaitlin; et al. (2015).TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model. CELL. 160 (6):1061-1071

Nalls, Mike A.; Pankratz, Nathan; Lill, Christina M.; et al. (2014). Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson’s disease. NATURE GENETICS. 46 (9)989-+

Guerreiro, Rita; Wojtas, Aleksandra; Bras, Jose; et al. (2013). TREM2 Variants in Alzheimer’s Disease. NEW ENGLAND JOURNAL OF MEDICINE. 368 (2): 355-358

Jones, Lesley; Holmans, Peter A.; Hamshere, Marian L.; et al. (2010). Genetic Evidence Implicates the Immune System and Cholesterol Metabolism in the Aetiology of Alzheimer’s Disease. PLOS ONE. 5 (11)

Hardy, JDuff, KHardy, KGPerez-Tur, JHutton, M(1998). Genetic dissection of Alzheimer’s disease and related dementias: amyloid and its relationship to tau. Nature Neuroscience. 1 (5): 355 – 358

Hardy JA, Higgins GA. (1992). Alzheimer’s disease: the amyloid cascade hypothesis. Science. 256 5054):184-5

Review Paper

Hardy, John. (2017). The discovery of Alzheimer-causing mutations in the APP gene and the formulation of the “amyloid cascade hypothesis”. FEBS JOURNAL. 284 (7): 1040-1044

Selkoe, Dennis J.; Hardy, John. (2016). The amyloid hypothesis of Alzheimer’s disease at 25years. EMBO MOLECULAR MEDICINE. 8 (6)595-608

Hampel, Harald; Frank, Richard; Broich, Karl; et al. (2010). Biomarkers for Alzheimer’s disease: academic, industry and regulatory perspectives. NATURE REVIEWS DRUG DISCOVERY. 9 (7)560-574

Book Chapter

Yu, Jin-Tai; Tan, Lan; Hardy, John. (2014). Apolipoprotein E in Alzheimer’s Disease: An Update. ANNUAL REVIEW OF NEUROSCIENCE. 3779-100

Hardy, John. (2012). Alzheimer’s disease and related dementias. NEUROGENETICS: A GUIDE FOR CLINICIANS. 17-31