Markus Library – Author Book Talk Dr. Siddhartha Mukherjee Thursday March 15, 2018 3:15 p.m.

Dr. Siddhartha Mukherjee
Cancer Physician, Researcher, and Pulitzer Prize winning Author
of The Emperor of All Maladies – New York, NY

Markus Library,  Welch Hall, Level Two Main Reading Room

Thursday, March 15, 2018

Reception at 3:15 and following the presentation.   Author presentation at 3:30

Dr. Mukherjee will share his thoughts and experiences on becoming a best selling author skilled at presenting science effectively to the non science community.

Copies of his 2016 book  The Gene: an Intimate History  will be available for sale at the book talk.



Recommended Readings: Sanford M. Simon, Ph.D. Monday March 19, 2018

Monday Lectures

Monday, March 19, 2018  4:00 p.m.

Carson Family Auditorium

Sanford M. Simon, Ph.D.

Professor and Head

Laboratory of Cellular Biophysics

The Rockefeller University

ESCRTing Viruses out of the Cell: Lessons from HIV-1

Recommended Readings:

Empirical Articles

Itano, Michelle S.; Arnion, Helene; Wolin, Sandra L.; et al. (2018). Recruitment of 7SL RNA to assembling HIV-1 virus-like particles. TRAFFIC. 19 (1): 36-43

Itano, Michelle S.; Bleck, Marina; Johnson, Daniel S.; et al. (2016). Readily Accessible Multiplane Microscopy: 3D Tracking the HIV-1 Genome in Living Cells. TRAFFIC. 17 (2): 179-186

Bleck, Marina; Itano, Michelle S.; Johnson, Daniel S.; et al. (2014). Temporal and spatial organization of ESCRT protein recruitment during HIV-1 budding. PNAS. 111 (33): 12211-12216

Jouvenet, Nolwenn; Zhadina, Maria; Bieniasz, Paul D.; et al. (2011). Dynamics of ESCRT protein recruitment during retroviral assembly. NATURE CELL BIOLOGY. 13 (4): 394-U124

Jouvenet, Nolwenn; Simon, Sanford M.; Bieniasz, Paul D. (2009). Imaging the interaction of HIV-1 genomes and Gag during assembly of individual viral particles. PNAS. 106 (45): 19114-19119

Jouvenet, Nolwenn; Bieniasz, Paul D.; Simon, Sanford M. (2008). Imaging the biogenesis of individual HIV-1 virions in live cells. NATURE. 454 (7201): 236-240

Review Papers

Jouvenet, Nolwenn; Simon, Sanford M.; Bieniasz, Paul D. (2011). Visualizing HIV-1 Assembly.  JOURNAL OF MOLECULAR BIOLOGY. 410 (4): 501-511

Book Chapter

Woolf, Steven H.; Purnell, Jason Q.; Simon, Sarah M.; et al. (2015). Translating Evidence into Population Health Improvement: Strategies and Barriers. ANNUAL REVIEW OF PUBLIC HEALTH. 36: 463-482


Recommended Readings: Lewis Cantley, Ph.D. Friday March 16, 2018

Friday Lectures

Friday, March 16, 2018  3:45 p.m.

Caspary Auditorium

Lewis Cantley, Ph.D.

Meyer Director of the Sandra and Edward Meyer Cancer Center


Professor of Cancer Biology in Medicine

Weill Cornell Medicine and New York-Presbyterian Hospital

PI 3-Kinase: Linking Obesity, Insulin Resistance, and Cancer

Recommended Readings:

Empirical Articles

Liu H, Murphy CJ, Karreth FA, Emdal KB, White FM, Elemento O, Toker A, Wulf GM, Cantley LC. (2018). Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple-Negative Breast Cancer. CANCER DISCOVERY. 8 (3):354-369

Waldhart, Althea N.; Dykstra, Holly; Peck, Anderson S.; et al. (2017).  Phosphorylation of TXNIP by AKT Mediates Acute Influx of Glucose in Response to Insulin. CELL REPORTS. 19 (10)2005-2013

Croessmann S, Sheehan JH, Lee KM, Sliwoski G, et al. (2017). PIK3CA C2 Domain Deletions Hyperactivate Phosphoinositide 3-kinase (PI3K), Generate Oncogene Dependence, and Are Exquisitely Sensitive to PI3Kα Inhibitors. CLINICAL CANCER RESEARCH. doi: 10.1158/1078-0432.CCR-17-2141

Fruman, David A.; Chiu, Honyin; Hopkins, Benjamin D.; et al. (2017). The PI3K Pathway in Human Disease. CELL. 170 (4)605-635 

Thorpe, Lauren M.; Spangle, Jennifer M.; Ohlson, Carolynn E.; et al. (2017). PI3K-p110 alpha mediates the oncogenic activity induced by loss of the novel tumor suppressorPI3K-p85 alpha. PNAS.114 (27)7095-7100

Juvekar, Ashish; Hu, Hai; Yadegarynia, Sina; et al. (2016). Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion. PNAS. 113 (30): E4338-E4347

Review Papers

Fruman, David A.; Chiu, Honyin; Hopkins, Benjamin D.; et al. (2017). The PI3K Pathway in Human Disease. CELL. 170 (4): 605-635

Heiden, Matthew G. Vander; Cantley, Lewis C.; Thompson, Craig B. (2009). Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation. SCIENCE. 324 (5930): 1029-1033

Yuan, T. L.; Cantley, L. C. (2008). PI3K pathway alterations in cancer: variations on a theme. ONCOGENE. 27 (41): 5497-5510

Book Chapter

Lien, Evan C.; Lyssiotis, Costas A.; Cantley, Lewis C. (2016). Metabolic Reprogramming by the PI3K-Akt-mTOR Pathway in Cancer. METABOLISM IN CANCER. 207: 39-72

Yuan, Tina L.; Cantley, Lewis C. (2010). Phosphoinositide 3-kinase in Health and Disease Volume 1 Introduction. PHOSPHOINOSITIDE 3-KINASE IN HEALTH AND DISEASE, VOL1. Current Topics in Microbiology and Immunology. 346: 1-7


Recommended Readings: Michael Greenberg, Ph.D. Friday March 9th, 2018

Friday Lectures

Friday, March 9th, 2018  3:45 p.m.

Caspary Auditorium

Michael Greenberg, Ph.D.

Department Chair and Nathan Marsh Pusey Professor

Department of Neurobiology

Harvard Medical School

How Nature and Nurture Conspire to Control Brain Development and Function

Recommended Readings:

Empirical Articles

Kalish, Brian T.; Cheadle, Lucas; Hrvatin, Sinisa; et al. (2018). Single-cell transcriptomics of the developing lateral geniculate nucleus reveals insights into circuit assembly and refinement. PNAS. 115 (5): E1051-E1060

Hrvatin, Sinisa; Hochbaum, Daniel R.; Nagy, M. Aurel; et al. (2018). Single-cell analysis of experience-dependent transcriptomic states in the mouse visual cortex. NATURE NEUROSCIENCE. 21 (1): 120-+

Gabel, Harrison W.; Kinde, Benyam; Stroud, Hume; et al. (2015). Disruption of DNA-methylation-dependent long gene repression in Rett syndrome. NATURE. 522 (7554): 89-U221

Malik, Athar N.; Vierbuchen, Thomas; Hemberg, Martin; et al. (2014). Genome-wide identification and characterization of functional neuronal activity-dependent enhancers. NATURE NEUROSCIENCE. 17 (10): 1330-1339

West, Anne E.; Greenberg, Michael E. (2011). Neuronal Activity-Regulated Gene Transcription in Synapse Development and Cognitive Function. COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY. 3 (6)

Greer, Paul L.; Hanayama, Rikinari; Bloodgood, Brenda L.; et al. (2010). The Angelman Syndrome Protein Ube3A Regulates Synapse Development by Ubiquitinating Arc. CELL. 140 (5): 704-716

Review Papers

Hardingham, Giles E.; Pruunsild, Priit; Greenberg, Michael E.; et al. (2018). Lineage divergence of activity-driven transcription and evolution of cognitive ability. NATURE REVIEWS NEUROSCIENCE. 19 (1): 9-15

Ebert, Daniel H.; Greenberg, Michael E. (2013). Activity-dependent neuronal signalling and autism spectrum disorder. NATURE. 493 (7432): 327-337

Book Chapter

Flavell, Steven W.; Greenberg, Michael E. (2008). Signaling mechanisms linking neuronal activity to gene expression and plasticity of the nervous system. ANNUAL REVIEW OF NEUROSCIENCE. 31: 563-590