Recommended Readings: Laura Landweber, Ph.D. Friday February 2nd, 2018

Friday Lectures

Friday, February 2nd, 2018  3:45 p.m.

Caspary Auditorium

Laura Landweber, Ph.D.

 Professor

Biochemistry and Molecular Biophysics and Biological Sciences

Columbia University

RNA-programmed genome rearrangement and editing in the ciliate Oxytricha

Recommended Readings:

Science News

Greg Miller. This Bizarre Organism Builds Itself a New Genome Every Time It Has Sex. (2014, Sep 17). Wired

Empirical Articles

Khurana, Jaspreet S.; Clay, Derek M.; Moreira, Sandrine; et al.(2018). Small RNA-mediated regulation of DNA dosage in the ciliate Oxytricha. RNA. 24 (1): 18-29

Lindblad, Kelsi A.; Bracht, John R.; Williams, April E.; et al. (2017). Thousands of RNA-cached copies of whole chromosomes are present in the ciliate Oxytricha during development. RNA. 23 (8): 1200-1208

Chen, Xiao; Bracht, John R.; Goldman, Aaron David; et al. (2014). The Architecture of a Scrambled Genome Reveals Massive Levels of Genomic Rearrangement during Development. CELL. 158 (5): 1187-1198

Swart, Estienne C.; Bracht, John R.; Magrini, Vincent; et al. (2013). The Oxytricha trifallax Macronuclear Genome: A Complex Eukaryotic Genome with 16,000 Tiny Chromosomes. PLOS BIOLOGY. 11 (1).

Goldman, Aaron David; Landweber, Laura F. (2012). Oxytricha as a modern analog of ancient genome evolution. TRENDS IN GENETICS. 28 (8): 382-388

Fang, Wenwen; Wang, Xing; Bracht, John R.; et al. (2012). Piwi-Interacting RNAs Protect DNA against Loss during Oxytricha Genome Rearrangement. CELL. 151 (6): 1243-1255

Nowacki, Mariusz; Haye, Joanna E.; Fang, Wenwen; et al. (2010). RNA-mediated epigenetic regulation of DNA copy number. PNAS. 107 (51): 22140-22144

Nowacki, Mariusz; Vijayan, Vikram; Zhou, Yi; et al. (2008). RNA-mediated epigenetic programming of a genome-rearrangement pathway. NATURE. 451 (7175): 153-U4

Review Papers

Bracht, John R.; Fang, Wenwen; Goldman, Aaron David; et al. (2013). Genomes on the Edge: Programmed Genome Instability in Ciliates. CELL. 152 (3): 406-416

Goldman, Aaron David; Landweber, Laura F. (2012). Oxytricha as a modern analog of ancient genome evolution. TRENDS IN GENETICS. 28 (8): 382-388

Book Chapter

Nowacki, Mariusz; Shetty, Keerthi; Landweber, Laura F. (2011). RNA-Mediated Epigenetic Programming of Genome Rearrangements. ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS. Book Series: Annual Review of Genomics and Human Genetics. 12: 367-389

Edited Books

Landweber, L. F. and Winfree, E., eds. (2003) Evolution as Computation. Springer Verlag.

Landweber, L. F. and Dobson, A. P., eds. (1999) Genetics and the Extinction of Species: DNA and the Conservation of Biodiversity. Princeton University Press. PLEASE REQUEST FROM MARKUS LIBRARY.

Landweber, L. and Baum, E., eds. (1998) DNA Based Computers II. American Mathematical Society. PLEASE REQUEST FROM MARKUS LIBRARY.

 

Avoid NIH Funding Rejections: Write a Winning Specific Aims Page & Narrative

NIH-Trained Grant Writer Helps You Make Your Application Stand Out and Get Funded

Don’t let the Specific Aims Page and Narrative section of your NIH grant application get you turned down for the research money you need.

This happens quite frequently in Peer Review meetings. The Specific Aims Page and Narrative section of your Abstract are the most critical aspects of your grant. They can make or break peer reviewer interest and enthusiasm and often immediately sink your grant before it is read in detail.

Despite the overwhelming importance of these sections, knowing how to use them to attract the attention of your reviewer is not straightforward. The good news is, that with an understanding of what NIH peer reviewers expect to see, you can make sure your grant gets noticed, which boosts your chances of funding approval. This is where medical researcher and educator, Christopher Dant, PhD, can help.

Dr. Dant is a former researcher, has written numerous successful NIH grants, and was trained in grant writing at the NIH. Most recently, he taught NIH grant writing at both Stanford and Dartmouth Medical Schools. Dr. Dant knows what it takes to get your grant approved, and during his upcoming online training session on Thursday, February 15th at 1pm ET, he wants to share this knowledge with you. This online training will help your application stand out above the fierce NIH grant competition. Ultimately, it will improve your opportunity to get the funding your research needs.

By attending this online training session with Dr. Dant, you’ll learn how to significantly improve your chances of getting your research noticed and ultimately funded. Here are just a few of the proven tactics you’ll learn by attending this expert-led training:

  • Construct your Specific Aims Page to incorporate exactly what NIH reviewers want
  • Proven lay language to use in your narrative section to show your grant’s relevance to human health and attract NIH peer reviewer attention
  • Write a more successful Aims page by mastering the concepts of Significance and Impact
  • Develop a systematic approach to writing your Specific Aims Page that gets you noticed
  • Use Significance and potential Impact to convince NIH reviewers that your research is worth funding
  • Uncover how your Specific Aims Page is KEY to your entire NIH application, and make it work for you
  • Make your grant rise to the top in terms of the importance and impact of your work
  • And so much more…

Registration is limited to ensure that Dr. Dant has time to answer all attendee specific questions during the Q&A portion of the training. Don’t wait, register today.

Reserve Your Access Today

Write More Effective Data Management Plans:
Give NIH Reviewers What They Want to See
and Get More of the Funding You Need

Immediately Available 60-Minute Online Training:
All formats (CD, MP4, PDF Transcript) include training presentation handouts.

The NIH requires Data Sharing Plans for all grants seeking $500k or more in direct costs in any one year, or as required by the solicitation. The Data Management Plan is more than a component of your proposal; it’s a blueprint for how you’ll actually manage the data during the course of your funded work. Therefore, creating an effective Data Management Plan is an integral part of creating a winning proposal and getting the research money you need.

During this expert-led online training session, you’ll learn what counts as data, and understand exactly what funding agencies expect and require for your Data Management Plan to be successful. Your expert presenter, Michael Lesiecki, PhD, will explain how you should think about managing your data before you begin your proposed research to insure usability, long-run preservation and access. During this training, you’ll examine proven models and processes so you can improve your Data Management Plan and create the most competitive proposal possible.

5 Key Take-Aways:

  • Optimally manage your data based on its type by utilizing proven samples, physical collections, software, curriculum materials, and other materials produced in the course of your funded project.
  • Master NIH expectations for your submitted proposal data and metadata.
  • Comply with NIH’s requirements expectations
    regarding the release of sensitive or proprietary data.
  • Give reviewers exactly what they are looking for in your Data Management Plan to improve your chances of proposal approval.
  • And much more…
    Who Should Attend:

  • Principal Investigators
  • Postdocs
  • Research Professors
  • Grant Writers
  • Sponsored Program Staff
  • All Senior Staff involved in the development of proposals and in the management of grant funded projects.

    .

 Expert Training Special Discount: Deadline Jan. 30th

By attending this online training session, you’ll receive proven Data Management Plan writing tactics from an
experienced  industry leader, Michael Lesiecki, PhD. As well as his other accomplishments, Dr. Lesiecki has served
as Principal Investigator on successful NIH and major NSF proposals, and as a reviewer for NSF and
Department of Labor grant proposals.

Register for this must-have online training by Tuesday, January 30th at midnight, and you’ll receive an
additional $40 off the regular list price. This online training is available for you immediately via CD, downloadable MP4,
or PDF transcript formats for only $157 (regular list price $197). Don’t delay, reserve your training session today.

Recommended Readings: Edward H. Egelman, Ph.D. Friday January 19th, 2018

Friday Lectures

Friday, January 19, 2018  3:45 p.m.

Caspary Auditorium

Edward Egelman, Ph.D.

Harrison Distinguished Professor

Biochemistry and Molecular Genetics

University of Virginia Medical School

Cryo-EM of Protein and Nucleoprotein Polymers at Near-Atomic Resolution

Recommended Readings:

Science News

Kenny Walter. Virus Holds Key to Durable Material. (2017, Jul 20). Virus Holds Key to Durable Material. R&D Magazine

Empirical Articles

Egelman, Edward H. (2017). Cryo-EM of bacterial pili and archaeal flagellar filaments. CURRENT OPINION IN STRUCTURAL BIOLOGY. 46: 31-37

Wang, Fengbin; Burrage, Andrew M.; Postel, Sandra; et al. (2017). A structural model of flagellar filament switching across multiple bacterial species. NATURE COMMUNICATIONS. 8: 960

Wang, Fengbin; Coureuil, Mathieu; Osinski, Tomasz; et al. (2017). Cryoelectron Microscopy Reconstructions of the Pseudomonas aeruginosa and Neisseria gonorrhoeae Type IV Pili at Sub-nanometer Resolution. STRUCTURE. 25 (9): 1423-+

Kasson, Peter; DiMaio, Frank; Yu, Xiong; et al. (2017). Model for a novel membrane envelope in a filamentous hyperthermophilic virus. ELIFE. 6  

Kolappan, Subramania; Coureuil, Mathieu; Yu, Xiong; et al. (2016). Structure of the Neisseria meningitidis Type IV pilus. NATURE COMMUNICATIONS. 7: 13015

Braun, Tatjana; Vos, Matthijn R.; Kalisman, Nir; et al. (2016). Archaeal flagellin combines a bacterial type IV pilin domain with an Ig-like domain. PNAS. 113 (37): 10352-10357

Egelman, Edward H. (2016). The Current Revolution in Cryo-EM. BIOPHYSICAL JOURNAL. 110 (5): 1008-1012

Wang, Ray Yu-Ruei; Kudryashev, Mikhail; Li, Xueming; et al. (2015). De novo protein structure determination from near-atomic-resolution cryo-EM maps. NATURE METHODS. 12 (4): 335-U84

DiMaio, Frank; Yu, Xiong; Rensen, Elena; et al. (2015). A virus that infects a hyperthermophile encapsidates A-form DNA. SCIENCE. 348 (6237): 914-917

Review Papers

Egelman, Edward H. (2015). Three-dimensional reconstruction of helical polymers. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 581: 54-58