Recommended Readings: Vamsi Mootha, M.D. Friday November 17th, 2017

Friday Lectures

Friday, November 17, 2017  3:45 p.m.

Caspary Auditorium

Vamsi Mootha, M.D.


Systems Biology and Medicine

Harvard Medical School and Massachusetts General Hospital

Genome-scale Approaches to Mitochondrial Disease

Recommended Readings:

Science News

Howard Hughes Medical Institute. (2017, May 8). Low oxygen reverses mitochondrial disease in mice. ScienceDaily

Empirical Articles

Ferrari, Michele; Jain, Isha H.; Goldberger, Olga; et al. (2017). Hypoxia treatment reverses neurodegenerative disease in a mouse model of Leigh syndrome. PNAS. 114 (21): E4241-E4250

Jain, Isha H.; Zazzeron, Luca; Goli, Rahul; et al. (2016). Hypoxia as a therapy for mitochondrial disease. SCIENCE. 352 (6281): 54-61  

Titov, Denis V.; Cracan, Valentin; Goodman, Russell P.; et al. (2016). Complementation of mitochondrial electron transport chain by manipulation of the NAD(+)/NADH ratio. SCIENCE. 352 (6282): 231-235

Calvo, Sarah E.; Clauser, Karl R.; Mootha, Vamsi K. (2016). MitoCarta2.0: an updated inventory of mammalian mitochondrial proteins.  NUCLEIC ACIDS RESEARCH. 44 (D1): D1251-D1257

Lake, Nicole J.; Bird, Matthew J.; Isohanni, Pirjo; et al. (2015). Leigh Syndrome: Neuropathology and Pathogenesis. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY. 74 (6): 482-492  

Lieber, Daniel S.; Calvo, Sarah E.; Shanahan, Kristy; et al. (2013). Targeted exome sequencing of suspected mitochondrial disorders. NEUROLOGY. 80 (19): 1762-1770

Calvo, Sarah E.; Compton, Alison G.; Hershman, Steven G.; et al. (2012). Molecular Diagnosis of Infantile Mitochondrial Disease with Targeted Next-Generation Sequencing. SCIENCE TRANSLATIONAL MEDICINE. 4 (118)

Calvo, S; Jain, M; Xie, XH; et al. (2006). Systematic identification of human mitochondrial disease genes through integrative genomics. NATURE GENETICS. 38 (5): 576-582

Review Papers

Kamer, Kimberli J.; Mootha, Vamsi K. (2015). The molecular era of the mitochondrial calcium uniporter.  NATURE REVIEWS MOLECULAR CELL BIOLOGY. 16 (9): 545-553

Vafai, Scott B.; Mootha, Vamsi K. (2012). Mitochondrial disorders as windows into an ancient organelle. NATURE. 491 (7424): 374-383

Book Chapter

Calvo, Sarah E.; Mootha, Vamsi K. (2010). The Mitochondrial Proteome and Human Disease. ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS. Book Series: Annual Review of Genomics and Human Genetics. 11: 25-44


Recommended Readings: Gregory M. Alushin, Ph.D. Monday November 13th, 2017

Monday Lectures

Monday, November 13, 2017  3:45 p.m.

Carson Family Auditorium

Gregory M. Alushin, Ph.D.

Assistant Professor and Head

Laboratory of Structural Biophysics and Mechanobiology

The Rockefeller University

Cytoskeletal Structural Plasticity in Force Generation and Mechanosensation

Recommended Readings:

Empirical Articles

Omabegho T, Gurel PS, Cheng CY, Kim LY, Ruijgrok PV, Das R, Alushin GM, Bryant Z. (2017). Controllable molecular motors engineered from myosin and RNA. NATURE NANOTECHNOLOGY. PLEASE REQUEST FROM MARKUS LIBRARY.

Swaminathan V, Alushin GM, Waterman CM. (2017). Mechanosensation: A Catch Bond That Only Hooks One Way. CURRENT BIOLOGY. 27 (21):R1158–R1160

Kim, Laura Y.; Thompson, Peter M.; Lee, Hyunna T.; et al. (2016). The Structural Basis of Actin Organization by Vinculin and Metavinculin. JOURNAL OF MOLECULAR BIOLOGY.  428 (1): 10-25

Skau, Colleen T.; Fischer, Robert S.; Gurel, Pinar; et al. (2016). FMN2 Makes Perinuclear Actin to Protect Nuclei during Confined Migration and Promote Metastasis. CELL. 167 (6):1571-+

Review Papers

Thomas DG, Robinson DN. (2017). The fifth sense: Mechanosensory regulation of alpha-actinin-4 and its relevance for cancer metastasis. SEMINARS IN CELL AND DEVELOPMENTAL BIOLOGY. PLEASE REQUEST FROM MARKUS LIBRARY.

Mishra, Mithilesh; Huang, Junqi; Balasubramanian, Mohan K. (2014). The yeast actin cytoskeleton. FEMS MICROBIOLOGY REVIEWS. 38 (2): 213-227

Book Chapter

Luo, Tianzhi; Robinson, Douglas N. (2011). The Role of the Actin Cytoskeleton in Mechanosensation. MECHANOSENSITIVITY AND MECHANOTRANSDUCTION. Mechanosensitivity in Cells and Tissues. 4: 25-65