Recommended Readings: Tarun Kapoor, Ph.D., April 18

Monday Lecture Series
Monday, April 18, 2016
4:00 p.m., Carson Family Auditorium (CRC)

Tarun Kapoor, Ph.D.
Pels Family Professor and Head,
Selma and Lawrence Ruben Laboratory of Chemistry and Cell Biology,
The Rockefeller University

New Chemical Probes for Ribosome Biogenesis and Cytoskeleton Organization

Recommended Readings

Kasap, C., Elemento, O., & Kapoor, T. M. (2014). DrugTargetSeqR: a genomics-and CRISPR-Cas9–based method to analyze drug targets. Nature Chemical Biology, 10(8), 626-628. doi: 10.1038/nchembio.1551

See, S. K., Hoogendoorn, S., Chung, A. H., Ye, F., Steinman, J. B., Sakata-Kato, T., … & Chen, J. K. (2015). Cytoplasmic dynein antagonists with improved potency and isoform selectivity. ACS Chemical Biology, 11(1), 53-60. doi:10.1021/acschembio.5b00895

Shimamoto, Y., Forth, S., & Kapoor, T. M. (2015). Measuring pushing and braking forces generated by ensembles of kinesin-5 crosslinking two microtubules. Developmental Cell, 34(6), 669-681. doi:10.1016/j.devcel.2015.08.017

Recommended Readings: Rod MacKinnon, M.D., Ph.D., April 11

Monday Lecture Series
Monday, April 11, 2016
4:00 p.m., Carson Family Auditorium (CRC)

Rod MacKinnon, M.D., Ph.D.
John D. Rockefeller Jr. Professor and Head,
Laboratory of Molecular Neurobiology and Biophysics,
The Rockefeller University
Investigator, Howard Hughes Medical Institute

Some Experiments That Excite Me Right Now

Recommended Readings

Brohawn, S. G., Campbell, E. B., & MacKinnon, R. (2014). Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel. Nature, 516(7529), 126-130. doi:10.1038/nature14013

Doyle, D. A., Cabral, J. M., Pfuetzner, R. A., Kuo, A., Gulbis, J. M., Cohen, S. L., … & MacKinnon, R. (1998). The structure of the potassium channel: molecular basis of K+ conduction and selectivity. Science, 280(5360), 69-77. doi:10.1126/science.280.5360.69

Hite, R. K., Yuan, P., Li, Z., Hsuing, Y., Walz, T., & MacKinnon, R. (2015). Cryo-electron microscopy structure of the Slo2. 2 Na+-activated K+ channel. Nature, 527(7577), 198-203.  doi:10.1038/nature14958

MacKinnon, R. (2004). Potassium channels and the atomic basis of selective ion conduction (Nobel Lecture). Angewandte Chemie, 43(33), 4265-4277.

Recommended Readings: Paul Cohen, M.D., Ph.D., April 25

Monday Lecture Series
Monday, April 25, 2016
4:00 p.m., Carson Family Auditorium (CRC)

Paul Cohen, M.D., Ph.D.
Albert Resnick, M.D., Assistant Professor and Head,
Laboratory of Molecular Metabolism,
The Rockefeller University

Molecular Regulation of Fat Cell Phenotype

Recommended Readings

Chi, J., & Cohen, P. (2016). The multifaceted roles of PRDM16: Adipose biology and beyond. Trends in Endocrinology & Metabolism, 27(1), 11-23. doi:10.1016/j.tem.2015.11.005

Cohen, P., Levy, J. D., Zhang, Y., Frontini, A., Kolodin, D. P., Svensson, K. J., … & Wu, J. (2014). Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch. Cell, 156(1), 304-316. doi:10.1016/j.cell.2013.12.021

Cohen, P., & Spiegelman, B. M. (2015). Brown and beige fat: molecular parts of a thermogenic machine. Diabetes, 64(7), 2346-2351. doi: 10.2337/db15-0318

Kir, S., White, J. P., Kleiner, S., Kazak, L., Cohen, P., Baracos, V. E., & Spiegelman, B. M. (2014). Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia. Nature, 513(7516), 100-104. doi:10.1038/nature13528

Recommended Readings: Jennifer Lippincott-Schwartz, Ph.D., April 22

Friday Lecture Series
Friday, April 22, 2016
3:45 p.m., Caspary Auditorium

Jennifer Lippincott-Schwartz, Ph.D.
Group Leader
Howard Hughes Medical Institute – Janelia Research Campus

Navigating the cellular landscape with new optical probes, imaging strategies and technical innovations

Recommended Readings

Chen, B. C., Legant, W. R., Wang, K., Shao, L., Milkie, D. E., Davidson, M. W., … & Betzig, E. (2014). Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution. Science, 346(6208), 1257998. doi:10.1126/science.1257998.

Ritter, A. T., Asano, Y., Stinchcombe, J. C., Dieckmann, N. M. G., Chen, B. C., Gawden-Bone, C., … & Betzig, E. (2015). Actin depletion initiates events leading to granule secretion at the immunological synapse. Immunity, 42(5), 864-876. doi:10.1016/j.immuni.2015.04.013.

Sengupta, P., Van Engelenburg, S., & Lippincott-Schwartz, J. (2012). Visualizing cell structure and function with point-localization superresolution imaging. Developmental Cell, 23(6), 1092-1102. doi: 10.1016/j.devcel.2012.09.022.

Shcherbakova, D. M., Sengupta, P., Lippincott-Schwartz, J., & Verkhusha, V. V. (2014). Photocontrollable fluorescent proteins for superresolution imaging. Annual Review of Biophysics, 43, 303-329. doi: 10.1146/annurev-biophys-051013-022836.

Recommended Readings: Tony Hunter, Ph.D., April 29

Friday Lecture Series
Friday, April 29, 2016
3:45 p.m., Caspary Auditorium

Tony Hunter, Ph.D.
Director, Molecular and Cell Biology Laboratory,
Renato Dulbecco Chair in Cancer Research,
American Cancer Society Professor,
Salk Institute for Biological Studies

Post-translational regulation of cell signaling

Recommended Readings

Hunter, T. (2014). The genesis of tyrosine phosphorylation. Cold Spring Harbor Perspectives in Biology, 6(5), a020644. doi: 10.1101/cshperspect.a020644

Hunter, T. (2015). Discovering the first tyrosine kinase. Proceedings of the National Academy of Sciences, 112(26), 7877–7882. doi: 10.1073/pnas.1508223112

Recommended Readings: Daniel Mucida, Ph.D., April 15

Friday Lecture Series
Friday, April 15, 2016
3:45 p.m., Caspary Auditorium

Daniel Mucida, Ph.D.
Assistant Professor and Head,
Laboratory of Mucosal Immunology,
The Rockefeller University

Tissue Adaptation: Implications for Immunity and Tolerance

Recommended Readings

Empirical Papers

Gabanyi, I., Muller, P. A., Feighery, L., Oliveira, T. Y., Costa-Pinto, F. A., & Mucida, D. (2016). Neuro-immune interactions drive tissue programming in intestinal macrophages. Cell, 164(3), 378-391. doi: doi: 10.1016/j.cell.2015.12.023.

Muller, P. A., Koscsó, B., Rajani, G. M., Stevanovic, K., Berres, M. L., Hashimoto, D., … & Stanley, E. R. (2014). Crosstalk between muscularis macrophages and enteric neurons regulates gastrointestinal motility. Cell, 158(2), 300-313. doi: 10.1016/j.cell.2014.04.050.

Schreiber, H. A., Loschko, J., Karssemeijer, R. A., Escolano, A., Meredith, M. M., Mucida, D., … & Nussenzweig, M. C. (2013). Intestinal monocytes and macrophages are required for T cell polarization in response to Citrobacter rodentium. The Journal of Experimental Medicine, 210(10), 2025-2039. doi: 10.1084/jem.20130903.

Review Papers

Reis, B. S., & Mucida, D. (2012). The role of the intestinal context in the generation of tolerance and inflammation. Clinical and Developmental Immunology, 157948, doi: 10.1155/2012/157948.

Recommended Readings: Cori Bargmann, Ph.D., April 4

Monday Lecture Series
Monday, April 4
4:00 p.m., Carson Family Auditorium (CRC)

Cori Bargmann, Ph.D.
Torsten N. Wiesel Professor and Head,
Lulu and Anthony Wang Laboratory of Neural Circuits and Behavior,
The Rockefeller University
Investigator, Howard Hughes Medical Institute

Themes and variations in circuits and behavior

Recommended Readings

Empirical Papers

Flavell, S. W., Pokala, N., Macosko, E. Z., Albrecht, D. R., Larsch, J., & Bargmann, C. I. (2013). Serotonin and the neuropeptide PDF initiate and extend opposing behavioral states in C. elegans. Cell, 154(5), 1023-1035. doi: 10.1016/j.cell.2013.08.001.

Gordus, A., Pokala, N., Levy, S., Flavell, S. W., & Bargmann, C. I. (2015). Feedback from network states generates variability in a probabilistic olfactory circuit. Cell, 161(2), 215-227. doi: 10.1016/j.cell.2015.02.018.

Jin, X., Pokala, N., & Bargmann, C. I. (2016). Distinct circuits for the formation and retrieval of an imprinted olfactory memory. Cell, 164(4), 632-643. doi: 10.1016/j.cell.2016.01.007.

Review Papers

Bargmann, C. I. (2006). Chemosensation in C. elegans. WormBook. doi/10.1895/wormbook.1.123.1

Bargmann, C. I., & Marder, E. (2013). From the connectome to brain function. Nature Methods, 10(6), 483-490. doi: 10.1038/nmeth.2451

Recommended Readings: Ruth Lehmann, Ph.D., April 1

Friday Lecture Series
Friday, April 1
3:45 p.m., Caspary Auditorium

Ruth Lehmann, Ph.D.
Laura and Isaac Perlmutter Professor of Cell Biology,
Director, Skirball Institute,
Chair, Department of Cell Biology,
New York University School of Medicine
Howard Hughes Medical Institute

Mechanisms and Function of Mitochondrial Inheritance in Germ Line Stem Cells

Recommended Readings

Slaidina, M., & Lehmann, R. (2014). Translational control in germline stem cell development. The Journal of Cell Biology, 207(1), 13-21. doi: 10.1083/jcb.201407102.

Teixeira, F. K., Sanchez, C. G., Hurd, T. R., Seifert, J. R., Czech, B., Preall, J. B., … & Lehmann, R. (2015). ATP synthase promotes germ cell differentiation independent of oxidative phosphorylation. Nature Cell Biology, 17(5), 689-696. doi: 10.1038/ncb3165.

Recommended Readings: Lydia Finley, Ph.D., March 30

Special Lecture
Wednesday, March 30
4:00 p.m., Carson Family Auditorium (CRC)

Lydia Finley, Ph.D.
Jack Sorrell Fellow,
Damon Runyon Cancer Research Foundation,
Cancer Biology and Genetics Program,
Memorial Sloan Kettering Cancer Center

Metabolic Regulation of Cell Fate Decisions

Recommended Readings

Carey, B. W., Finley, L. W., Cross, J. R., Allis, C. D., & Thompson, C. B. (2015). Intracellular [agr]-ketoglutarate maintains the pluripotency of embryonic stem cells. Nature, 518(7539), 413-416.  doi: 10.1038/nature13981.

Intlekofer, A. M., Dematteo, R. G., Venneti, S., Finley, L. W., Lu, C., Judkins, A. R., … & Thompson, C. B. (2015). Hypoxia induces production of L-2-hydroxyglutarate, Cell Metabolism, 22(2), 304-311. doi: 10.1016/j.cmet.2015.06.023.

Jeong, S. M., Xiao, C., Finley, L. W., Lahusen, T., Souza, A. L., Pierce, K., … & Xu, X. (2013). SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism. Cancer Cell, 23(4), 450-463. doi: 10.1016/j.ccr.2013.02.024.

Laurent, G., de Boer, V. C., Finley, L. W., Sweeney, M., Lu, H., Schug, T. T., … & Haigis, M. C. (2013). SIRT4 represses peroxisome proliferator-activated receptor α activity to suppress hepatic fat oxidation. Molecular and Cellular Biology, 33(22), 4552-4561. doi: 10.1128/MCB.00087-13.