Recommended Readings: Bruce Beutler, M.D., March 25

Friday Lecture Series
Friday, March 25
3:45 p.m., Caspary Auditorium

Bruce Beutler, M.D.
Regental Professor,
Director, Center for the Genetics of Host Defense,
Raymond and Ellen Willie Distinguished Chair in Cancer Research,
University of Texas Southwestern Medical Center

Saturation Mutagenesis of the Mouse Genome with Real-time Identification of Causative Mutations

Recommended Readings

Empirical Articles

Shi, H., Wang, Y., Li, X., Zhan, X., Tang, M., Fina, M., … & Beutler, B. (2015). NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component. Nature Immunology. 17(3), 250-258. doi: 10.1038/ni.3333.

Wang, T., Zhan, X., Bu, C. H., Lyon, S., Pratt, D., Hildebrand, S., … & Beutler, B. (2015). Real-time resolution of point mutations that cause phenovariance in mice. Proceedings of the National Academy of Sciences, 112(5), E440-E449. doi: 10.1073/pnas.1423216112.

Review Paper

Simon, M. M., Moresco, E. M. Y., Bull, K. R., Kumar, S., Mallon, A. M., Beutler, B., & Potter, P. K. (2015). Current strategies for mutation detection in phenotype-driven screens utilising next generation sequencing. Mammalian Genome, 26(9-10), 486-500. doi: 10.1007/s00335-015-9603-x

Recommended Readings: Anne Brunet, Ph.D., March 11

Friday Lecture Series
Friday, March 11
3:45 p.m., Caspary Auditorium

Anne Brunet, Ph.D.
Michele and Timothy Barakett Endowed Professor,
Department of Genetics,
Stanford University School of Medicine

Epigenetic and Metabolic Regulation of Aging

Recommended Readings

Empirical Articles

Benayoun, B. A., Pollina, E. A., Ucar, D., Mahmoudi, S., Karra, K., Wong, E. D., … & Brunet, A. (2014). H3K4me3 breadth is linked to cell identity and transcriptional consistency. Cell, 158(3), 673-688. doi: 10.1016/j.cell.2014.06.027

Greer, E. L., Maures, T. J., Hauswirth, A. G., Green, E. M., Leeman, D. S., Maro, G. S., … & Brunet, A. (2010). Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans. Nature, 466(7304), 383-387. doi: 10.1038/nature09195

Greer, E. L., Maures, T. J., Ucar, D., Hauswirth, A. G., Mancini, E., Lim, J. P., … & Brunet, A. (2011). Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans. Nature, 479(7373), 365-371. doi: 10.1038/nature10572

Review Papers

Benayoun, B. A., Pollina, E. A., & Brunet, A. (2015). Epigenetic regulation of ageing: linking environmental inputs to genomic stability. Nature Reviews Molecular Cell Biology, 16(10), 593-610. doi:10.1038/nrm4048

Lim, J. P., & Brunet, A. (2013). Bridging the transgenerational gap with epigenetic memory. Trends in Genetics, 29(3), 176-186. doi: 10.1016/j.tig.2012.12.008

Recommended Readings: Carlos D. Bustamante, Ph.D., March 18

Friday Lecture Series
Friday, March 18
3:45 p.m., Caspary Auditorium

Carlos D. Bustamante, Ph.D.
Professor of Biomedical Data Science and Genetics,
Founding Director,
Stanford Center for Computational, Evolutionary, and Human Genomics
Director of Informatics,
Stanford Center for Genomics and Personalized Medicine,
Stanford School of Medicine

Population and Medical Genomics in the Personal Genome Era

Recommended Readings

Grubert, F., Zaugg, J. B., Kasowski, M., Ursu, O., Spacek, D. V., Martin, A. R., … & Heidari, N. (2015). Genetic control of chromatin states in humans involves local and distal chromosomal interactions. Cell, 162(5), 1051-1065. doi: 10.1016/j.cell.2015.07.048.

Henn, B. M., Botigue, L. R., Peischl, S., Dupanloup, I., Lipatov, M., Maples, B. K., … & Excoffier, L. (2015). Distance from sub-Saharan Africa predicts mutational load in diverse human genomes. Proceedings of the National Academy of Sciences, 113(4), E440-E449. doi: 10.1073/pnas.1510805112

Shringarpure, S. S., & Bustamante, C. D. (2015). Privacy risks from genomic data-sharing beacons. The American Journal of Human Genetics, 97(5), 631-646. doi: 10.1016/j.ajhg.2015.09.010.

Recommended Readings: Charles Rice, Ph.D., March 4

Friday Lecture Series
Friday, March 4
3:45 p.m., Caspary Auditorium

Charles M. Rice, Ph.D.
Maurice R. and Corinne P. Greenberg Professor in Virology and Head,
Laboratory of Virology and Infectious Disease,
The Rockefeller University

Hepatitis C and Beyond

Recommended Readings

Empirical Articles

Catanese, M. T., Uryu, K., Kopp, M., Edwards, T. J., Andrus, L., Rice, W. J., … & Rice, C. M. (2013). Ultrastructural analysis of hepatitis C virus particles. Proceedings of the National Academy of Sciences, 110(23), 9505-9510. doi: 10.1073/pnas.1307527110

Dorner, M., Horwitz, J. A., Donovan, B. M., Labitt, R. N., Budell, W. C., Friling, T., … & Akira, S. (2013). Completion of the entire hepatitis C virus life cycle in genetically humanized mice. Nature, 501(7466), 237-241. doi:10.1038/nature12427

Luna, J. M., Scheel, T. K., Danino, T., Shaw, K. S., Mele, A., Fak, J. J., … & Jacobson, I. M. (2015). Hepatitis C virus RNA functionally sequesters miR-122. Cell, 160(6), 1099-1110. doi:10.1016/j.cell.2015.02.025

Saeed, M., Andreo, U., Chung, H. Y., Espiritu, C., Branch, A. D., Silva, J. M., & Rice, C. M. (2015). SEC14L2 enables pan-genotype HCV replication in cell culture. Nature, 524(7566), 471–475 doi:10.1038/nature14899

Review Papers

Lindenbach, B. D., & Rice, C. M. (2013). The ins and outs of hepatitis C virus entry and assembly. Nature Reviews Microbiology, 11(10), 688-700. doi: 10.1038/nrmicro3098

Scheel, T. K., & Rice, C. M. (2013). Understanding the hepatitis C virus life cycle paves the way for highly effective therapies. Nature Medicine, 19(7), 837-849. doi: 10.1038/nm.3248

Recommended Readings: Lindsay Schwarz, Ph.D., March 7

Special Seminar
Monday, March 7
4:00 p.m., Carson Family Auditorium (CRC)

Lindsay Schwarz, Ph.D.
Postdoctoral Fellow,
Department of Biology,
Stanford University

New Approaches for Uncovering Norepinephrine Circuit Organization and Function

Recommended Readings

Schwarz, L. A., & Luo, L. (2015). Organization of the locus coeruleus-norepinephrine system. Current Biology, 25(21), R1051-R1056. doi: 10.1016/j.cub.2015.09.039.

Schwarz, L. A., Miyamichi, K., Gao, X. J., Beier, K. T., Weissbourd, B., DeLoach, K. E., … & Luo, L. (2015). Viral-genetic tracing of the input-output organization of a central noradrenaline circuit. Nature, 524(7563), 88-92. doi: 10.1038/nature14600.

Recommended Readings: David Schneider, Ph.D., March 14

Special Seminar
Friday, March 14
4:00 p.m., Carson Family Auditorium (CRC)

David Schneider, Ph.D.
Postdoctoral Fellow,
Department of Neurobiology,
Duke University

Sensory and Motor Circuits for Listening and Learning

Recommended Readings

Empirical Articles

Nelson, A., Schneider, D. M., Takatoh, J., Sakurai, K., Wang, F., & Mooney, R. (2013). A circuit for motor cortical modulation of auditory cortical activity. The Journal of Neuroscience, 33(36), 14342-14353. doi: 10.1523/JNEUROSCI.2275-13.2013.

Schneider, D. M., Nelson, A., & Mooney, R. (2014). A synaptic and circuit basis for corollary discharge in the auditory cortex. Nature, 513(7517), 189-194. doi: 10.1038/nature13724.

Schneider, D. M., & Woolley, S. M. (2013). Sparse and background-invariant coding of vocalizations in auditory scenes. Neuron, 79(1), 141-152. doi: 10.1016/j.neuron.2013.04.038.

Review Paper

Schneider, D. M., & Mooney, R. (2015). Motor-related signals in the auditory system for listening and learning. Current Opinion in Neurobiology, 33, 78-84. doi: 10.1016/j.conb.2015.03.004.

Recommended Readings: Vanessa Ruta, Ph.D., February 26

Friday Lecture Series
The Detlev W. Bronk Alumni Lecture, Ph.D. Recruitment Lecture
Friday, February 26
3:45 p.m., Caspary Auditorium

Vanessa Ruta, Ph.D.
Gabrielle H. Reem and Herbert J. Kayden Assistant Professor,
Laboratory of Neurophysiology and Behavior,
The Rockefeller University

Neural Circuits for Adaptive Behaviors

Recommended Readings

Caron, S. J., Ruta, V., Abbott, L. F., & Axel, R. (2013). Random convergence of olfactory inputs in the Drosophila mushroom body. Nature, 497(7447), 113-117. doi: 10.1038/nature12063.

Clowney, E. J., Iguchi, S., Bussell, J. J., Scheer, E., & Ruta, V. (2015). Multimodal chemosensory circuits controlling male courtship in Drosophila. Neuron, 87(5), 1036-1049. doi: 10.1016/j.neuron.2015.07.025.

Cohn, R., Morantte, I., & Ruta, V. (2015). Coordinated and compartmentalized neuromodulation shapes sensory processing in Drosophila. Cell, 163(7), 1742-1755. doi: 10.1016/j.cell.2015.11.019.