Recommended Readings: John Kuryian, Ph.D., January 29

Friday Lecture Series
Friday, January 29, 2016

3:45 p.m., Caspary Auditorium

John Kuriyan, Ph.D.
Professor,
Department of Molecular and Cell Biology,
Department of Chemistry,
University of California, Berkeley,
Investigator, Howard Hughes Medical Institute

Control of Catalytic Activity in the EGF Receptor

Recommended Reading

Empirical Articles

Jura, N., Shan, Y., Cao, X., Shaw, D. E., & Kuriyan, J. (2009). Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3. Proceedings of the National Academy of Sciences, 106(51), 21608-21613. doi:10.1073/pnas.0912101106.

Zhang, X., Gureasko, J., Shen, K., Cole, P. A., & Kuriyan, J. (2006). An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor. Cell, 125(6), 1137-1149. doi:10.1016/j.cell.2006.05.013

Zhang, X., Pickin, K. A., Bose, R., Jura, N., Cole, P. A., & Kuriyan, J. (2007). Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface. Nature, 450(7170), 741-744. doi: 10.1038/nature05998

Review Papers

Jura, N., Zhang, X., Endres, N. F., Seeliger, M. A., Schindler, T., & Kuriyan, J. (2011). Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms. Molecular Cell, 42(1), 9-22. doi: 10.1016/j.molcel.2011.03.004.

Kovacs, E., Zorn, J. A., Huang, Y., Barros, T., & Kuriyan, J. (2015). A structural perspective on the regulation of the epidermal growth factor receptor. Annual Review of Biochemistry, 84, 739-764. doi: 10.1146/annurev-biochem-060614-034402.

Recommended Readings: Emmanuelle Charpentier, Ph.D., January 22

Friday Lecture Series
Friday, January 22, 2016
3:45 p.m., Caspary Auditorium

Emmanuelle Charpentier, Ph.D.
Professor, Department of Regulation in Infection Biology
Director, Max Planck Institute for Infection Biology;
Visiting Professor, Laboratory for Molecular Infection Medicine Sweden, Umeå University

The Transformative Genome Engineering Technology CRISPR-Cas9: Lessons Learned from bacteria

Recommended Reading

Empirical Articles

Chylinski, K., Le Rhun, A., & Charpentier, E. (2013). The tracrRNA and Cas9 families of type II CRISPR-Cas immunity systems. RNA Biology, 10(5), 726-737. doi:10.4161/rna.24321

Fonfara, I., Le Rhun, A., Chylinski, K., Makarova, K. S., Lécrivain, A. L., Bzdrenga, J., … & Charpentier, E. (2014). Phylogeny of Cas9 determines functional exchangeability of dual-RNA and Cas9 among orthologous type II CRISPR-Cas systems. Nucleic acids research, 42(4), 2577-2590. doi:10.1093/nar/gkt1074.

Jinek, M., Chylinski, K., Fonfara, I., Hauer, M., Doudna, J. A., & Charpentier, E. (2012). A programmable dual-RNA–guided DNA endonuclease in adaptive bacterial immunity. Science, 337(6096), 816-821. doi:10.1126/science.1225829.

Review Papers

Charpentier, E., Richter, H., van der Oost, J., & White, M. F. (2015). Biogenesis pathways of RNA guides in archaeal and bacterial CRISPR-Cas adaptive immunity. FEMS Microbiology Reviews, 39(3), 428-441. doi:10.1093/femsre/fuv023.

Chylinski, K., Makarova, K. S., Charpentier, E., & Koonin, E. V. (2014). Classification and evolution of type II CRISPR-Cas systems. Nucleic acids research, 42(10), 6091-6105. doi:10.1093/nar/gku241

Recommended Readings: Roy Parker, Ph.D., January 8

Friday Lecture Series
Friday, January 8, 2016
3:45 p.m., Caspary Auditorium

Roy Parker, Ph.D.
Cech-Leinwand Endowed Chair of Chemistry and Biochemistry,
Department of Chemistry and Biochemistry,
University of Colorado at Boulder
Investigator, Howard Hughes Medical Institute

mRNP Granules in Health and Disease

Recommended Reading

Empirical Articles

Buchan, J. R., Kolaitis, R. M., Taylor, J. P., & Parker, R. (2013). Eukaryotic stress granules are cleared by autophagy and Cdc48/VCP function. Cell, 153(7), 1461-1474. doi:10.1016/j.cell.2013.05.037.

Buchan, J. R., Muhlrad, D., & Parker, R. (2008). P bodies promote stress granule assembly in Saccharomyces cerevisiae. The Journal of Cell Biology, 183(3), 441-455. doi:10.1083/jcb.200807043.

Swisher, K. D., & Parker, R. (2010). Localization to, and effects of Pbp1, Pbp4, Lsm12, Dhh1, and Pab1 on stress granules in Saccharomyces cerevisiae. PLOS ONE, 5(4), e10006. doi:10.1371/journal.pone.0010006.

Yoon, J. H., Choi, E. J., & Parker, R. (2010). Dcp2 phosphorylation by Ste20 modulates stress granule assembly and mRNA decay in Saccharomyces cerevisiae. The Journal of Cell Biology, 189(5), 813-827.

Review Papers

Mitchell, S. F., & Parker, R. (2014). Principles and properties of eukaryotic mRNPs. Molecular Cell, 54(4), 547-558. doi:10.1016/j.molcel.2014.04.033.

Ramaswami, M., Taylor, J. P., & Parker, R. (2013). Altered ribostasis: RNA-protein granules in degenerative disorders. Cell, 154(4), 727-736. doi:10.1016/j.cell.2013.07.038.

Recommended Readings: Paul Bieniasz, Ph.D., December 14th

Monday Lecture Series
Monday, December 14, 2015
4:00 p.m., Carson Family Auditorium (CRC)

Paul Bieniasz, Ph.D.
Professor and Head,
Laboratory of Retrovirology,
The Rockefeller University and Aaron Diamond AIDS Research Center
Investigator, Howard Hughes Medical Institute

Retroviruses vs. Cells in Ancient and Modern Times

Recommended Reading

Empirical Articles

Busnadiego, I., Kane, M., Rihn, S. J., Preugschas, H. F., Hughes, J., Blanco-Melo, D., … & Wilson, S. J. (2014). Host and viral determinants of Mx2 antiretroviral activity. Journal of Virology, 88(14), 7738-7752. doi:10.1128/JVI.00214-14.

Hatziioannou, T., Del Prete, G. Q., Keele, B. F., Estes, J. D., McNatt, M. W., Bitzegeio, J., … & Bieniasz, P. D. (2014). HIV-1–induced AIDS in monkeys. Science, 344(6190), 1401-1405. doi:10.1126/science.1250761.

Kane, M., Yadav, S. S., Bitzegeio, J., Kutluay, S. B., Zang, T., Wilson, S. J., … & Bieniasz, P. D. (2013). MX2 is an interferon-induced inhibitor of HIV-1 infection. Nature, 502(7472), 563-566. doi:10.1038/nature12653.

Kutluay, S. B., Zang, T., Blanco-Melo, D., Powell, C., Jannain, D., Errando, M., & Bieniasz, P. D. (2014). Global changes in the RNA binding specificity of HIV-1 gag regulate virion genesis. Cell, 159(5), 1096-1109. doi:10.1016/j.cell.2014.09.057.

Rihn, S. J., Hughes, J., Wilson, S. J., & Bieniasz, P. D. (2015). Uneven genetic robustness of HIV-1 integrase. Journal of Virology, 89(1), 552-567. doi: 10.1128/JVI.02451-14.

Review Papers

Malim, M. H., & Bieniasz, P. D. (2012). HIV restriction factors and mechanisms of evasion. Cold Spring Harbor Perspectives in Medicine, 2(5), a006940.  doi:10.1101/cshperspect.a006940.