Recommended Readings: Thomas Jessell, Ph.D., December 4th

Friday Lecture Series
Friday, December 4, 2015
3:45 p.m., Caspary Auditorium

Thomas Jessell, Ph.D.
Claire Tow Professor,
Department of Neuroscience,
Department of Biochemistry and Molecular Biophysics,
Columbia University Medical Center
Investigator, Howard Hughes Medical Institute

Strategies and Circuits for Skilled Movement

Recommended Reading

Empirical Articles

Azim, E., Jiang, J., Alstermark, B., & Jessell, T. M. (2014). Skilled reaching relies on a V2a propriospinal internal copy circuit. Nature, 508(7496), 357-363. doi:10.1038/nature13021.

Fink, A. J., Croce, K. R., Huang, Z. J., Abbott, L. F., Jessell, T. M., & Azim, E. (2014). Presynaptic inhibition of spinal sensory feedback ensures smooth movement. Nature, 509(7498), 43-48. doi:10.1038/nature13276.

Mendelsohn, A. I., Simon, C. M., Abbott, L. F., Mentis, G. Z., & Jessell, T. M. (2015). Activity regulates the incidence of heteronymous sensory-motor connections. Neuron, 87(1), 111-123. doi:10.1016/j.neuron.2015.05.045.

Zampieri, N., Jessell, T. M., & Murray, A. J. (2014). Mapping sensory circuits by anterograde transsynaptic transfer of recombinant rabies virus. Neuron, 81(4), 766-778. doi:10.1016/j.neuron.2013.12.033.

Review Paper

Azim, E., Fink, A. J., & Jessell, T. M. (2014). Internal and external feedback circuits for skilled forelimb movement. Cold Spring Harbor Symposia on Quantitative Biology, 79, 81-92. doi: 10.1101/sqb.2014.79.024786.

Recommended Readings: Titia de Lange, Ph.D., December 7th

Monday Lecture Series
Monday, December 7, 2015
4:00 p.m., Carson Family Auditorium (CRC)

Titia de Lange, Ph.D.
Leon Hess Professor and Head,
Laboratory of Cell Biology and Genetics,
The Rockefeller University

Telomere-derived Genome Instability in Cancer

Recommended Readings

Davoli, T., & de Lange, T. (2011). The causes and consequences of polyploidy in normal development and cancer. Annual review of cell and developmental biology, 27, 585-610. doi:10.1146/annurev-cellbio-092910-154234

Davoli, T., & de Lange, T. (2012). Telomere-driven tetraploidization occurs in human cells undergoing crisis and promotes transformation of mouse cellsCancer Cell, 21(6), 765-776. doi:10.1016/j.ccr.2012.03.044

de Lange, T. (2005). Telomere-related genome instability in cancer. Cold Spring Harbor Symposia on Quantitative Biology, 70, 197-204. doi:10.1101/sqb.2005.70.032

Recommended Readings: David C. Gadsby, Ph.D., November 30th

Monday Lecture Series
Monday, November 30, 2015
4:00 p.m., Carson Family Auditorium (CRC)

David C. Gadsby, Ph.D.
Patrick A. Gerschel Family Professor and Head
Laboratory of Cardiac and Membrane Physiology,
The Rockefeller University

Motions that gate single CFTR channels, the ABC proteins whose failure causes cystic fibrosis

Recommended Readings

Chaves, L. A. P., & Gadsby, D. C. (2015). Cysteine accessibility probes timing and extent of NBD separation along the dimer interface in gating CFTR channels. The Journal of General Physiology, 145(4), 261-283. doi:10.1085/jgp.201411347

Csanády, L., Vergani, P., & Gadsby, D. C. (2010). Strict coupling between CFTR’s catalytic cycle and gating of its Cl− ion pore revealed by distributions of open channel burst durations. Proceedings of the National Academy of Sciences, 107(3), 1241-1246. doi:10.1073/pnas.0911061107

Gadsby, D. C., Vergani, P., & Csanády, L. (2006). The ABC protein turned chloride channel whose failure causes cystic fibrosis. Nature, 440(7083), 477-483. doi:10.1038/nature04712

Vergani, P., Lockless, S. W., Nairn, A. C., & Gadsby, D. C. (2005). CFTR channel opening by ATP-driven tight dimerization of its nucleotide-binding domains. Nature, 433(7028), 876-880. doi:10.1038/nature03313