Recommended Readings: Susan Kaech, Ph.D., September 14th

Monday Lecture Series
Monday, September 14th, 2015
4:00 p.m., Carson Family Auditorium (CRC)

Susan Kaech, Ph.D.
Associate Professor of Immunobiology,
Yale School of Medicine
Early Career Scientist,
Howard Hughes Medical Institute

PEPing Up T Cell-mediated Immunity to Viruses and Cancer

Recommended Readings

Empirical Articles

Cui, G., Staron, M. M., Gray, S. M., Ho, P. C., Amezquita, R. A., Wu, J., & Kaech, S. M. (2015). IL-7-induced glycerol transport and TAG synthesis promotes memory CD8+ T cell longevity. Cell, 161(4), 750-761. doi:10.1016/j.cell.2015.03.021.

Laidlaw, B. J., Cui, W., Amezquita, R. A., Gray, S. M., Guan, T., Lu, Y., … & Kaech, S. M. (2015). Production of IL-10 by CD4+ regulatory T cells during the resolution of infection promotes the maturation of memory CD8+ T cells. Nature Immunology, 16(8), 871-879. doi:10.1038/ni.3224

Laidlaw, B. J., Zhang, N., Marshall, H. D., Staron, M. M., Guan, T., Hu, Y., … & Kaech, S. M. (2014). CD4+ T cell help guides formation of CD103+ lung-resident memory CD8+ T cells during influenza viral infection. Immunity, 41(4), 633-645. doi:10.1016/j.immuni.2014.09.007.

Slütter, B., Pewe, L. L., Kaech, S. M., & Harty, J. T. (2013). Lung airway-surveilling CXCR3 hi memory CD8+ T cells are critical for protection against influenza A virus. Immunity, 39(5), 939-948. doi:10.1016/j.immuni.2013.09.013.

Review Paper

Gray, S. M., Kaech, S. M., & Staron, M. M. (2014). The interface between transcriptional and epigenetic control of effector and memory CD8+ T‐cell differentiation. Immunological Reviews, 261(1), 157-168. doi:10.1111/imr.12205.

Kaech, S. M., & Cui, W. (2012). Transcriptional control of effector and memory CD8+ T cell differentiation. Nature Reviews Immunology, 12(11), 749-761. doi:10.1038/nri3307.

Recommended Readings: Jonas Frisén, M.D., Ph.D., October 16th

Friday Lecture Series
Friday, October 16, 2015
3:45 p.m., Caspary Auditorium

Jonas Frisén, M.D., Ph.D.
Tobias Foundation Professor of Stem Cell Research,
Department of Cell and Molecular Biology,
Karolinska Institutet, Stockholm, Sweden

Cellular Plasticity in the Intact and Injured Central Nervous System

Recommended Readings

Empirical Articles

Ernst, A., Alkass, K., Bernard, S., Salehpour, M., Perl, S., Tisdale, J., … & Frisén, J. (2014). Neurogenesis in the striatum of the adult human brain. Cell, 156(5), 1072-1083. doi: 10.1016/j.cell.2014.01.044

Magnusson, J. P., Göritz, C., Tatarishvili, J., Dias, D. O., Smith, E. M., Lindvall, O., … & Frisén, J. (2014). A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse. Science, 346(6206), 237-241. doi: 10.1126/science.346.6206.237.

Sabelström, H., Stenudd, M., Réu, P., Dias, D. O., Elfineh, M., Zdunek, S., … & Frisén, J. (2013). Resident neural stem cells restrict tissue damage and neuronal loss after spinal cord injury in mice. Science, 342(6158), 637-640. doi: 10.1126/science.1242576

Review Paper

Bergmann, O., Spalding, K. L., & Frisén, J. (2015). Adult neurogenesis in humans. Cold Spring Harbor Perspectives in Biology, 7(7), a018994. doi: 10.1101/cshperspect.a018994

Recommended Readings: Gulcin Pekkurnaz, Ph.D., September 21

Special Lecture
Monday, September 21, 2015
4:00 p.m., Carson Family Auditorium (CRC)

Gulcin Pekkurnaz, Ph.D.,
Postdoctoral Fellow,
Department of Neurobiology,
Harvard Medical School
Boston Children’s Hospital

Metabolic Regulation of Mitochondrial Function in the Nervous System

Recommended Readings

Empirical Articles

Pekkurnaz, G., Trinidad, J. C., Wang, X., Kong, D., & Schwarz, T. L. (2014). Glucose regulates mitochondrial motility via Milton modification by O-GlcNAc transferase. Cell, 158(1), 54-68. doi: 10.1016/j.cell.2014.06.007

Teodoro, R. O., Pekkurnaz, G., Nasser, A., Higashi‐Kovtun, M. E., Balakireva, M., McLachlan, I. G., … & Schwarz, T. L. (2013). Ral mediates activity‐dependent growth of postsynaptic membranes via recruitment of the exocyst. The EMBO Journal, 32(14), 2039-2055. doi: 10.1038/emboj.2013.147

Review Papers

Schwarz, T. L. (2013). Mitochondrial trafficking in neurons. Cold Spring Harbor Perspectives in Biology, 5(6), a011304. doi: 10.1101/cshperspect.a011304