Recommended Readings: Paul Cohen, M.D., Ph.D. June 24

Special Seminar 
Tuesday, June 24, 2014
4:00 p.m., Carson Family Auditorium

Paul Cohen, M.D., Ph.D.
Postdoctoral Fellow, Dana Farber Cancer Institute
Attending Cardiologist, Brigham and Women’s Hospital
Instructor in Medicine, Harvard Medical School

Transcriptional Determinants of Subcutaneous and Visceral Adipose Tissue: Towards Engineering Healthier Fat

Recommended Readings:

Empirical Articles

Cohen, P., Levy, J. D., Zhang, Y., Frontini, A., Kolodin, D. P., Svensson, K. J., … Spiegelman, B. M. (2014). Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch. Cell, 156(1-2), 304–16. doi:10.1016/j.cell.2013.12.021

Seale, P., Conroe, H. M., Estall, J., Kajimura, S., Frontini, A., Ishibashi, J., … Spiegelman, B. M. (2011). Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice. The Journal of Clinical Investigation, 121(1), 53–56. doi:10.1172/JCI44271.96

Review Papers

Wu, J., Cohen, P., & Spiegelman, B. M. (2013). Adaptive thermogenesis in adipocytes: is beige the new brown? Genes & Development, 27(3), 234–50. doi:10.1101/gad.211649.112

Recommended Readings: Thomas Walz, Ph.D. June 23

Special Seminar 
Monday, June 23, 2014
4:00 p.m., Carson Family Auditorium

Thomas Walz, Ph.D
Professor, Department of Cell Biology
Harvard Medical School
Investigator, Howard Hughes Medical Institute

Using Two-dimensional Crystals of Aquaporin-0 to Investigate Lipid-Protein Interactions

Recommended Readings:

Empirical Articles

Aponte-Santamaría, C., Briones, R., Schenk, A. D., Walz, T., & de Groot, B. L. (2012). Molecular driving forces defining lipid positions around aquaporin-0. Proceedings of the National Academy of Sciences, 109(25), 9887–9892. doi:10.1073/pnas.1121054109

Gonen, T., Cheng, Y., Sliz, P., Hiroaki, Y., Fujiyoshi, Y., Harrison, S. C., & Walz, T. (2005). Lipid-protein interactions in double-layered two-dimensional AQP0 crystals. Nature, 438(7068), 633–638. doi:10.1038/nature04321

Gonen, T., Sliz, P., Kistler, J., Cheng, Y., & Walz, T. (2004). Aquaporin-0 membrane junctions reveal the structure of a closed water pore. Nature, 429(6988), 193–197. doi:10.1038/nature02503

Hite, R. K., Li, Z., & Walz, T. (2010). Principles of membrane protein interactions with annular lipids deduced from aquaporin-0 2D crystals. The EMBO Journal, 29(10), 1652–1658. doi:10.1038/emboj.2010.68

Review Papers

Gonen, T., & Walz, T. (2006). The structure of aquaporins. Quarterly Reviews of Biophysics, 39(4), 361–396. doi:10.1017/S0033583506004458

Raunser, S., & Walz, T. (2009). Electron crystallography as a technique to study the structure on membrane proteins in a lipidic environment. Annual Review of Biophysics, 38, 89–105. doi:10.1146/annurev.biophys.050708.133649