Recommended Readings: Robert Lefkowitz, M.D. May 9

Friday Lecture Series
Friday, May 9, 2014
3:45 p.m., Carson Family Auditorium

Robert Lefkowitz, M.D.
James B. Duke Professor of Medicine
Professor of Biochemistry
Duke University
Investigator, Howard Hughes Medical Institute

Seven Transmembrane Receptors

Recommended Readings:

Empirical Articles

Hara, M. R., Kovacs, J. J., Whalen, E. J., Rajagopal, S., Strachan, R. T., Grant, W., … Lefkowitz, R. J. (2011). A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1. Nature, 477(7364), 349–353. doi:10.1038/nature10368

Kahsai, A. W., Xiao, K., Rajagopal, S., Ahn, S., Shukla, A. K., Sun, J., … Lefkowitz, R. J. (2011). Multiple ligand-specific conformations of the β2-adrenergic receptor. Nature Chemical Biology, 7(10), 692–700. doi:10.1038/nchembio.634

Rajagopal, S., Ahn, S., Rominger, D. H., Gowen-macdonald, W., Lam, C. M., Dewire, S. M., … Lefkowitz, R. J. (2011). Quantifying ligand bias at seven-transmembrane receptors. Molecular Pharmacology, 80(3), 367–3. doi:10.1124/mol.111.072801.

Shukla, A. K., Manglik, A., Kruse, A. C., Xiao, K., Reis, R. I., Tseng, W.-C., … Lefkowitz, R. J. (2013). Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide. Nature, 497(7447), 137–141. doi:10.1038/nature12120

Review Papers

DeWire, S. M., Ahn, S., Lefkowitz, R. J., & Shenoy, S. K. (2007). β-Arrestins and Cell Signaling. Annual Review of Physiology, 69(1), 483–510. doi:10.1146/annurev.physiol.69.022405.154749

Lefkowitz, R. J., & Shenoy, S. K. (2005). Transduction of receptor signals by beta-arrestins. Science, 308(5721), 512–517. doi:10.1126/science.1109237

Pierce, K. L., Premont, R. T., & Lefkowitz, R. J. (2002). Seven-transmembrane receptors. Nature Reviews Molecular Cell Biology, 3(9), 639–50. doi:10.1038/nrm908

Wisler, J. W., Xiao, K., Thomsen, A. R., & Lefkowitz, R. J. (2014). Recent developments in biased agonism. Current Opinion in Cell Biology, 27, 18–24. doi:10.1016/