Recommended Readings: Allan C Spradling, Ph.D. May 16

Friday Lecture Series
Friday, May 16, 2014
3:45 p.m., Caspary Auditorium

Allan C Spradling, Ph.D.
Director, Department of Embryology
Carnegie Institution for Science

Investigator, Howard Hughes Medical Institute

Epigenetic and genetic programing of Drosophila development

Recommended Readings:

Empirical Articles

Morris, L. X., & Spradling, A. C. (2011). Long-term live imaging provides new insight into stem cell regulation and germline-soma coordination in the Drosophila ovary. Development, 138(11), 2207–2215. doi:10.1242/dev.065508

Nystul, T., & Spradling, A. (2007). An epithelial niche in the Drosophila ovary undergoes long-range stem cell replacement. Cell Stem Cell, 1(3), 277–285. doi:10.1016/j.stem.2007.07.009

Skora, A. D., & Spradling, A. C. (2010). Epigenetic stability increases extensively during Drosophila follicle stem cell differentiation. Proceedings of the National Academy of Sciences, 107(16), 7389–7394. doi:10.1073/pnas.1003180107

Xie, T., & Spradling, A. C. (2000). A niche maintaining germ line stem cells in the Drosophila ovary. Science, 290(5490), 328–330. doi:10.1126/science.290.5490.328

Review Papers

Losick, V. P., Morris, L. X., Fox, D. T., & Spradling, A. (2011). Drosophila stem cell niches: a decade of discovery suggests a unified view of stem cell regulation. Developmental Cell, 21(1), 159–171. doi:10.1016/j.devcel.2011.06.018

Morrison, S. J., & Spradling, A. C. (2008). Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. Cell, 132(4), 598–611. doi:10.1016/j.cell.2008.01.038

Recommended Readings: Sangeeta Bhatia, M.D., Ph.D. May 12

SPECIAL SEMINAR
Monday, May 12, 2014
4:00 p.m., Carson Family Auditorium

Sangeeta Bhatia, M.D., Ph.D.
John J. and Dorothy Wilson Professor of Health Sciences & Technology
Institute for Medical Engineering and Science
Director, Laboratory for Multiscale Regenerative Technologies
Massachusetts Institute of Technology
Investigator, Howard Hughes Medical Institute

Tiny Technologies for Studying Tissue Microenvironments

Recommended Readings:

Empirical Papers

Chen, A., & Thomas, D. (2011). Humanized mice with ectopic artificial liver tissues. Proceedings of the National Academy of Sciences, 108(29), 11842–11847. doi:10.1073/pnas.1101791108

Hui, E. E., & Bhatia, S. N. (2007). Micromechanical control of cell-cell interactions. Proceedings of the National Academy of Sciences, 104(14), 5722–5726. doi:10.1073/pnas.0608660104

Khetani, S. R., & Bhatia, S. N. (2008). Microscale culture of human liver cells for drug development. Nature Biotechnology, 26(1), 120–126. doi:10.1038/nbt1361

Review Papers

Underhill, G. H., Galie, P., Chen, C. S., & Bhatia, S. N. (2012). Bioengineering methods for analysis of cells in vitro. Annual Review of Cell and Developmental Biology, 28, 385–410. doi:10.1146/annurev-cellbio-101011-155709

Wong, I. Y., Bhatia, S. N., & Toner, M. (2013). Nanotechnology: emerging tools for biology and medicine. Genes & Development, 27(22), 2397–2408. doi:10.1101/gad.226837.113

Recommended Readings: Robert Lefkowitz, M.D. May 9

Friday Lecture Series
Friday, May 9, 2014
3:45 p.m., Carson Family Auditorium

Robert Lefkowitz, M.D.
James B. Duke Professor of Medicine
Professor of Biochemistry
Duke University
Investigator, Howard Hughes Medical Institute

Seven Transmembrane Receptors

Recommended Readings:

Empirical Articles

Hara, M. R., Kovacs, J. J., Whalen, E. J., Rajagopal, S., Strachan, R. T., Grant, W., … Lefkowitz, R. J. (2011). A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1. Nature, 477(7364), 349–353. doi:10.1038/nature10368

Kahsai, A. W., Xiao, K., Rajagopal, S., Ahn, S., Shukla, A. K., Sun, J., … Lefkowitz, R. J. (2011). Multiple ligand-specific conformations of the β2-adrenergic receptor. Nature Chemical Biology, 7(10), 692–700. doi:10.1038/nchembio.634

Rajagopal, S., Ahn, S., Rominger, D. H., Gowen-macdonald, W., Lam, C. M., Dewire, S. M., … Lefkowitz, R. J. (2011). Quantifying ligand bias at seven-transmembrane receptors. Molecular Pharmacology, 80(3), 367–3. doi:10.1124/mol.111.072801.

Shukla, A. K., Manglik, A., Kruse, A. C., Xiao, K., Reis, R. I., Tseng, W.-C., … Lefkowitz, R. J. (2013). Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide. Nature, 497(7447), 137–141. doi:10.1038/nature12120

Review Papers

DeWire, S. M., Ahn, S., Lefkowitz, R. J., & Shenoy, S. K. (2007). β-Arrestins and Cell Signaling. Annual Review of Physiology, 69(1), 483–510. doi:10.1146/annurev.physiol.69.022405.154749

Lefkowitz, R. J., & Shenoy, S. K. (2005). Transduction of receptor signals by beta-arrestins. Science, 308(5721), 512–517. doi:10.1126/science.1109237

Pierce, K. L., Premont, R. T., & Lefkowitz, R. J. (2002). Seven-transmembrane receptors. Nature Reviews Molecular Cell Biology, 3(9), 639–50. doi:10.1038/nrm908

Wisler, J. W., Xiao, K., Thomsen, A. R., & Lefkowitz, R. J. (2014). Recent developments in biased agonism. Current Opinion in Cell Biology, 27, 18–24. doi:10.1016/j.ceb.2013.10.008

Recommended Readings: David Kingsley, Ph.D.

Friday Lecture Series

The Fairfield Osborn Memorial Lecture

Fishing for the Secrets of Vertebrate Evolution

David Kingsley, Ph.D., professor, developmental biology, Stanford University;

investigator, Howard Hughes Medical Institute

April 18, 2014

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

han, Y. F., Marks, M. E., Jones, F. C., Villarreal Jr., G., Shapiro, M. D., Brady, S. D., . . . Kingsley, D. M. (2010). Adaptive evolution of pelvic reduction in sticklebacks by recurrent deletion of a pitxl enhancer. Science, 327(5963), 302-305

Haussler, D., O’Brien, S. J., Ryder, O. A., Keith Barker, F., Clamp, M., Crawford, A. J., . . . Turner, S. (2009). Genome 10K: A proposal to obtain whole-genome sequence for 10000 vertebrate species. Journal of Heredity, 100(6), 659-674

Jones, F. C., Grabherr, M. G., Chan, Y. F., Russell, P., Mauceli, E., Johnson, J., . . . Kingsley, D. M. (2012). The genomic basis of adaptive evolution in threespine sticklebacks. Nature, 484(7392), 55-61

Kingsley, D. M., Zhu, B., Osoegawa, K., De Jong, P. J., Schein, J., Marra, M., . . . Myers, R. (2004). New genomic tools for molecular studies of evolutionary change in threespine sticklebacks. Behaviour, 141(11-12), 1331-1344

Lowe, C. B., Kellis, M., Siepel, A., Raney, B. J., Clamp, M., Salama, S. R., . . . Haussler, D. (2011). Three periods of regulatory innovation during vertebrate evolution. Science, 333(6045), 1019-1024

Shapiro, M. D., Bell, M. A., & Kingsley, D. M. (2006). Parallel genetic origins of pelvic reduction in vertebrates. Proceedings of the National Academy of Sciences of the United States of America, 103(37), 13753-13758

 

Recommended Readings: Hermann Steller, Ph.D May 5

Monday Lecture Series
Monday, May 5, 2014
4:00 p.m., Carson Family Auditorium

Hermann Steller, Ph.D
Strang Professor, Strang Laboratory of Apoptosis and Cancer Biology
The Rockefeller University
Investigator, Howard Hughes Medical Institute

Regulation of Protein Degradation in Development, Aging and Disease

Recommended Readings:

Empirical Articles

Bader, M., Benjamin, S., Wapinski, O. L., Smith, D. M., Goldberg, A. L., & Steller, H. (2011). A conserved F box regulatory complex controls proteasome activity in Drosophila. Cell, 145(3), 371–382. doi:10.1016/j.cell.2011.03.021

Cho-Park, P. F., & Steller, H. (2013). Proteasome regulation by ADP-ribosylation. Cell, 153(3), 614–627. doi:10.1016/j.cell.2013.03.040

Review Papers

Finley, D. (2009). Recognition and processing of ubiquitin-protein conjugates by the proteasome. Annual Review of Biochemistry, 78(1), 477–513. doi:10.1146/annurev.biochem.78.081507.101607

Glickman, M. H., & Ciechanover, A. (2002). The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Physiological Reviews, 82(2), 373–428. doi:10.1152/physrev.00027.2001

Murata, S., Yashiroda, H., & Tanaka, K. (2009). Molecular mechanisms of proteasome assembly. Nature Reviews Molecular Cell Biology, 10(2), 104–15. doi:10.1038/nrm2630

Recommended Readings: Mark M. Davis, Ph.D. April 25

Friday Lecture Series
Friday, April 25, 2014
3:45 p.m., Caspary Auditorium

Mark M. Davis, Ph.D.
Burt and Marion Avery Family Professor of Immunology
Director, Stanford Institute for Immunity, Transplantation and Infection
Member, Bio-X and Stanford Cancer Institute
Stanford University

Reinventing Human Immunology

Recommended Readings:

Davis, M. M. (2008). A prescription for human immunology. Immunity, 29(6), 835–838. doi:10.1016/j.immuni.2008.12.003

Davis, M. M. (2012). Immunology taught by humans. Science Translational Medicine, 4(117), 117fs2. doi:10.1126/scitranslmed.3003385

Kidd, B. a, Peters, L. a, Schadt, E. E., & Dudley, J. T. (2014). Unifying immunology with informatics and multiscale biology. Nature Immunology, 15(2), 118–127. doi:10.1038/ni.2787

Maecker, H. T., McCoy, J. P., & Nussenblatt, R. (2012). Standardizing immunophenotyping for the Human Immunology Project. Nature Reviews Immunology, 12(3), 191–200. doi:10.1038/nri3158

Su, L. F., Han, A., McGuire, H. M., Furman, D., Newell, E. W., & Davis, M. M. (2014). The Promised Land of Human Immunology. Cold Spring Harbor Symposia on Quantitative Biology. doi:10.1101/sqb.2013.78.022905

Recommended Readings: Susan L. Ackerman, Ph.D. May 2

Friday Lecture Series
Friday, April 25, 2014
3:45 p.m., Caspary Auditorium

Susan L. Ackerman, Ph.D.
Professor, The Jackson Laboratory
Investigator, Howard Hughes Medical Institute

Multicopy Genes Encoding Functional RNAs and Their Role in the CNS

Recommended Readings:

Empirical Articles

Jia, Y., Mu, J. C., & Ackerman, S. L. (2012). Mutation of a U2 snRNA gene causes global disruption of alternative splicing and neurodegeneration. Cell, 148(1-2), 296–308. doi:10.1016/j.cell.2011.11.057

Liu, Y., Zaun, H. C., Orlowski, J., & Ackerman, S. L. (2013). CHP1-mediated NHE1 biosynthetic maturation is required for Purkinje cell axon homeostasis. The Journal of Neuroscience, 33(31), 12656–12669. doi:10.1523/JNEUROSCI.0406-13.2013

Zhao, L., Longo-Guess, C., Harris, B. S., Lee, J.-W., & Ackerman, S. L. (2005). Protein accumulation and neurodegeneration in the woozy mutant mouse is caused by disruption of SIL1, a cochaperone of BiP. Nature Genetics, 37(9), 974–979. doi:10.1038/ng1620

Review Papers

Cooper, T. A, Wan, L., & Dreyfuss, G. (2009). RNA and disease. Cell, 136(4), 777–793. doi:10.1016/j.cell.2009.02.011

Lemmens, R., Moore, M. J., Al-Chalabi, A., Brown, R. H., & Robberecht, W. (2010). RNA metabolism and the pathogenesis of motor neuron diseases. Trends in Neurosciences, 33(5), 249–258. doi:10.1016/j.tins.2010.02.003

Recommended Readings: Wiley Prize in Biomedical Sciences

Friday Lecture Series

Wiley Prize in Biomedical Sciences

Deborah E. Wiley, chair, The Wiley Foundation, Welcome

Gunter Blobel, Ph.D., chair, Wiley Prize Jury, Award Presentation and Introduction of Award Lecture

William G. Kaelin, Jr., M.D., professor, Dana-Farber Cancer Institute and Brigham and Women’s Hospital, Harvard Medical School; investigator, Howard Hughes Medical Institute, Lessons from von Hippel-Lindau Disease

Steven McKnight, Ph.D., professor and chairman, department of biochemistry, University of Texas Southwestern Medical Center, Hitting the Bullseye of HIF2a, the Kidney Cancer Oncoprotein

Peter J. Ratcliffe, M.D., professor and head, Nuffield Department of Medicine, University of Oxford, From Epo to Oxygen: Elucidation of Hypoxia Sensing in Animals

Gregg L. Semenza, M.D., Ph.D., professor and director, vascular program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Regulation of Oxygen Homeostasis by Hypoxia-inducible Factors

April 11, 2014

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Beckmann, R., Spahn, C. M. T., Eswar, N., Helmers, J., Penczek, P. A., Sali, A., . . . Blobel, G. (2001). Architecture of the protein-conducting channel associated with the translating 80S ribosome. Cell, 107(3), 361-372

Kaelin Jr., W. G., & McKnight, S. L. (2013). Influence of metabolism on epigenetics and disease. Cell, 153(1), 56-69

McKnight, S. L. (2010). On getting there from here. Science, 330(6009), 1338-1339

Ratcliffe, P. J. (2013). Oxygen sensing and hypoxia signalling pathways in animals: The implications of physiology for cancer. Journal of Physiology, 591(8), 2027-2042

Semenza, G. L. (2013). Cancer-stromal cell interactions mediated by hypoxia-inducible factors promote angiogenesis, lymphangiogenesis, and metastasis. Oncogene, 32(35), 4057-4063

 

 

Recommended Readings: David D. Ho, M.D. April 21

Monday Lecture Series
Monday, April 21, 2014
4:00 p.m., Carson Family Auditorium

David D. Ho, M.D.
Irene Diamond Professor
Senior Physician
Scientific Director
Chief Executive Officer
Aaron Diamond AIDS Research Center
The Rockefeller University

Long-acting Antibodies and Drugs as Prophylactics in HIV Prevention

Recommended Readings:

Empirical Papers

Andrews, C. D., Spreen, W. R., Mohri, H., Moss, L., Ford, S., Gettie, A., … Ho, D. D. (2014). Long-acting integrase inhibitor protects macaques from intrarectal simian/human immunodeficiency virus. Science, 343(6175), 1151–1154. doi:10.1126/science.1248707

Baeten, J. M., Donnell, D., Ndase, P., Mugo, N. R., Campbell, J. D., Wangisi, J., … Celum, C. (2012). Antiretroviral prophylaxis for HIV prevention in heterosexual men and women. The New England Journal of Medicine, 367(5), 399–410. doi:10.1056/NEJMoa1108524

Grant, R. M., Lama, J. R., Anderson, P. L., McMahan, V., Liu, A. Y., Vargas, L., … Glidden, D. V. (2010). Preexposure chemoprophylaxis for HIV prevention in men who have sex with men. The New England Journal of Medicine, 363(27), 2587–2599. doi:10.1056/NEJMoa1011205

Song, R., Oren, D. a, Franco, D., Seaman, M. S., & Ho, D. D. (2013). Strategic addition of an N-linked glycan to a monoclonal antibody improves its HIV-1-neutralizing activity. Nature Biotechnology, 31(11), 1047–1052. doi:10.1038/nbt.2677

Review Articles

Spreen, W. R., Margolis, D. a, & Pottage, J. C. (2013). Long-acting injectable antiretrovirals for HIV treatment and prevention. Current Opinion in HIV and AIDS, 8(6), 565–571. doi:10.1097/COH.0000000000000002

Recommended Readings: David Ginty, Ph.D.

Friday Lecture Series

The Sensory Neurons of Touch

David Ginty, Ph.D., Edward R. and Anne G. Lefler Professor,

department of neurobiology, Harvard Medical School;

investigator, Howard Hughes Medical Institute

April 4, 2014

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Abraira, V., & Ginty, D. (2013). The sensory neurons of touch. Neuron, 79(4), 618-639

Deppmann, C. D., Mihalas, S., Sharma, N., Lonze, B. E., Niebur, E., & Ginty, D. D. (2008). A model for neuronal competition during development. Science, 320(5874), 369-373

Li, L., Rutlin, M., Abraira, V. E., Cassidy, C., Kus, L., Gong, S., . . . Ginty, D. D. (2011). The functional organization of cutaneous low-threshold mechanosensory neurons. Cell, 147(7), 1615-1627

Luo, W., Wickramasinghe, S. R., Savitt, J. M., Griffin, J. W., Dawson, T. M., & Ginty, D. D. (2007). A hierarchical NGF signaling cascade controls ret-dependent and ret-independent events during development of nonpeptidergic DRG neurons. Neuron, 54(5), 739-754

Riccio, A., Alvania, R. S., Lonze, B. E., Ramanan, N., Kim, T., Huang, Y., . . . Ginty, D. D. (2006). A nitric oxide signaling pathway controls CREB-mediated gene expression in neurons. Molecular Cell, 21(2), 283-294

Wickramasinghe, S. R., Alvania, R. S., Ramanan, N., Wood, J. N., Mandai, K., & Ginty, D. D. (2008). Serum response factor mediates NGF-dependent target innervation by embryonic DRG sensory neurons. Neuron, 58(4), 532-545