Monday Lecture Series
Monday, May 19, 2014
4:00 p.m., Carson Family Auditorium
James E. Darnell, Jr., M.D.
Vincent Astor Professor Emeritus
Head, Laboratory of Molecular Cell Biology
The Rockefeller University
Then and now – making mRNA: an unbiased (?) look at pre-mRNA synthesis and processing
Brenner, S., Jacob, F., & Meselson, M. (1961). An unstable intermediate carrying information from genes to ribosomes for protein synthesis. Nature, 180(4776), 576–581.
Gros, F., Hiatt, H., Gilbert, W., & Kurland, C. (1961). Unstable ribonucleic acid revealed by pulse labelling of Escherichia coli. Nature, 190(4776), 581–585.
Jacob, F., & Monod, J. (1961). Genetic regulatory mechanisms in the synthesis of proteins. Journal of Molecular Biology, 3, 318–356.
Scherrer, K., Latham, H., & Darnell, J. E. (1963). Demonstration of an unstable RNA and of a precursor to ribosomal RNA in HeLa cells. Proceedings of the National Academy of Sciences, 49(2), 240–248.
Darnell, J. E. (1968). Ribonucleic acids from animal cells. Bacteriological Reviews, 32(3), 262–290.
Darnell, J. E. (2013). Reflections on the history of pre-mRNA processing and highlights of current knowledge: a unified picture. RNA, 19(4), 443–60. doi:10.1261/rna.038596.113
Licatalosi, D. D., & Darnell, R. B. (2010). RNA processing and its regulation: global insights into biological networks. Nature Reviews Genetics, 11(1), 75–87. doi:10.1038/nrg2673