Recommended Readings: Roderick MacKinnon, M.D.

Friday Lecture Series

Inaugural Bruce Merrifield Distinguished Lecture; Ph.D. Recruitment Lecture

The Incredible Diversity of K+ Channels

Roderick MacKinnon, M.D., John D. Rockefeller Jr. Professor, and head,

Laboratory of Molecular Neurobiology and Biophysics, The Rockefeller University;

investigator, Howard Hughes Medical Institute

 March 1, 2012

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Hansen, S. B., Tao, X., & MacKinnon, R. (2011). Structural basis of PIP 2 activation of the classical inward rectifier K + channel Kir2.2. Nature, 477(7365), 495-498

Lee, S. -., Banerjee, A., & MacKinnon, R. (2009). Two separate interfaces between the voltage sensor and pore are required for the function of voltage-dependent K + channels. PLoS Biology, 7(3)

Lee, S. -., Lee, A., Chen, J., & MacKinnon, R. (2005). Structure of the KvAP voltage-dependent K + channel and its on the lipid membrane. Proceedings of the National Academy of Sciences of the United States of America, 102(43), 15441-15446

Long, S. B., Tao, X., Campbell, E. B., & MacKinnon, R. (2007). Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment. Nature, 450(7168), 376-382

Schmidt, D., & MacKinnon, R. (2008). Voltage-dependent K + channel gating and voltage sensor toxin sensitivity depend on the mechanical state of the lipid membrane. Proceedings of the National Academy of Sciences of the United States of America, 105(49), 19276-19281

Tao, X., Avalos, J. L., Chen, J., & MacKinnon, R. (2009). Crystal structure of the eukaryotic strong inward-rectifier K + channel Kir2.2 at 3.1 Å resolution. Science, 326(5960), 1668-1674

 

Recommended Readings: Kang Shen, Ph.D.

Friday Lecture Series

Extracellular and Intracellular Mechanisms of Synapse Patterning in C. elegans

Kang Shen, Ph.D., M.P.H., associate professor,

department of biological sciences, Stanford University

 February 22, 2012

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Allen, P. B., Sgro, A. E., Chao, D. L., Doepker, B. E., Edgar, J. S., Shen, K., & Chiu, D. T. (2008). Single-synapse ablation and long-term imaging in live C. elegans. Journal of Neuroscience Methods, 173(1), 20-26

Crane, M. M., Stirman, J. N., Ou, C. -., Kurshan, P. T., Rehg, J. M., Shen, K., & Lu, H. (2012). Autonomous screening of C. elegans identifies genes implicated in synaptogenesis. Nature Methods, 9(10), 977-980

Klassen, M. P., Wu, Y. E., Maeder, C. I., Nakae, I., Cueva, J. G., Lehrman, E. K., . . . Shen, K. (2010). An arf-like small G protein, ARL-8, promotes the axonal transport of presynaptic cargoes by suppressing vesicle aggregation. Neuron, 66(5), 710-723

Maeder, C. I., & Shen, K. (2011). Genetic dissection of synaptic specificity. Current Opinion in Neurobiology, 21(1), 93-99

Margeta, M. A., Wang, G. J., & Shen, K. (2009). Clathrin adaptor AP-1 complex excludes multiple postsynaptic receptors from axons in C. elegans. Proceedings of the National Academy of Sciences of the United States of America, 106(5), 1632-1637

 

Recommended Readings: Maurice Swanson, Ph.D.

Friday Lecture Series

RNA-mediated Pathways to Disease

Maurice Swanson, Ph.D., associate director, Center for NeuroGenetics,

and professor of molecular genetics and microbiology,

University of Florida College of Medicine

 February 15, 2012

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Daughters, R. S., Tuttle, D. L., Gao, W., Ikeda, Y., Moseley, M. L., Ebner, T. J., . . . Ranum, L. P. W. (2009). RNA gain-of-function in spinocerebellar ataxia type 8. PLoS Genetics, 5(8)

Ho, T. H., Savkur, R. S., Poulos, M. G., Mancini, M. A., Swanson, M. S., & Cooper, T. A. (2005). Colocalization of muscleblind with RNA foci is separable from mis-regulation of alternative splicing in myotonic dystrophy. Journal of Cell Science, 118(13), 2923-2933

Kanadia, R. N., Shin, J., Yuan, Y., Beattie, S. G., Wheeler, T. M., Thornton, C. A., & Swanson, M. S. (2006). Reversal of RNA missplicing and myotonia after muscleblind overexpression in a mouse poly(CUG) model for myotonic dystrophy. Proceedings of the National Academy of Sciences of the United States of America, 103(31), 11748-11753

Osborne, R. J., Lin, X., Welle, S., Sobczak, K., O’Rourke, J. R., Swanson, M. S., & Thornton, C. A. (2009). Transcriptional and post-transcriptional impact of toxic RNA in myotonic dystrophy. Human Molecular Genetics, 18(8), 1471-1481

Shin, J., Charizanis, K., & Swanson, M. S. (2009). Pathogenic RNAs in microsatellite expansion disease. Neuroscience Letters, 466(2), 99-102

Yuan, Y., Compton, S. A., Sobczak, K., Stenberg, M. G., Thornton, C. A., Griffith, J. D., & Swanson, M. S. (2007). Muscleblind-like 1 interacts with RNA hairpins in splicing target and pathogenic RNAs. Nucleic Acids Research, 35(16), 5474-5486

 

NIH Announces Discovery of Promising Drug Target to Prevent S. aureus Infections

ScienceDaily February 10, 2013.   National Institutes of Health (NIH) scientists have identified a promising lead for developing a new type of drug to treat infection caused by Staphylococcus aureus, notable drug-resistant pathogen. They have discovered a transport system for toxins that are thought to contribute to severe staph infections – phenol-soluble modulins (PSMs). The transport system, Pmt, is common to all S. aureus PSMs and critical for bacterial proliferation and disease development in a mouse model. Their experiments suggest that a drug interfering with Pmt’s function could not only prevent production of the PSM toxins, but also directly lead to bacterial death. This research is reported in Nature Medicine.

Recommended Readings: Craig Montell, Ph.D.

Friday Lecture Series

Control of Animal Behavior and Decision Making through TRP Channels

Craig Montell, Ph.D., Duggan Professor,

department of molecular, cellular and developmental biology,

University of California, Santa Barbara

 February 8, 2012

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Kwon, Y., Kim, S. H., Ronderos, D. S., Lee, Y., Akitake, B., Woodward, O. M., . . . Montell, C. (2010). Drosophila TRPA1 channel is required to avoid the naturally occurring insect repellent citronellal. Current Biology, 20(18), 1672-1678

Lee, Y., Moon, S. J., & Montell, C. (2009). Multiple gustatory receptors required for the caffeine response in drosophila. Proceedings of the National Academy of Sciences of the United States of America, 106(11), 4495-4500

Liu, Z., Wang, X., Yu, Y., Li, X., Wang, T., Jiang, H., . . . Smith, W. W. (2008). A drosophila model for LRRK2-linked parkinsonism. Proceedings of the National Academy of Sciences of the United States of America, 105(7), 2693-2698

Montell, C. (2005). The TRP superfamily of cation channels. Science’s STKE [Electronic Resource] : Signal Transduction Knowledge Environment., 2005(272)

Waldo, G. L., Ricks, T. K., Hicks, S. N., Cheever, M. L., Kawano, T., Tsuboi, K., . . . Kendall Harden, T. (2010). Kinetic scaffolding mediated by a phospholipase C-β and G q signaling complex. Science, 330(6006), 974-980