Recommended Readings: Christer Betsholtz, Ph.D.

Friday Lecture Series

It Takes Two to Make a Blood Vessel: Endothelial/Pericyte Interactions in Angiogenesis and Vascular Permeability

Christer Betsholtz, Ph.D., professor of vascular biology,

The Karolinska Institute

October 26, 2012

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Armulik, A., G. Genové, and C. Betsholtz. 2011. “Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises.” Developmental Cell 21 (2): 193-215

Armulik, A., G. Genové, M. Mäe, M. H. Nisancioglu, E. Wallgard, C. Niaudet, L. He, et al. 2010. “Pericytes Regulate the Blood-Brain Barrier.” Nature 468 (7323): 557-561

Bell, R. D., E. A. Winkler, I. Singh, A. P. Sagare, R. Deane, Z. Wu, D. M. Holtzman, et al. 2012. “Apolipoprotein e Controls Cerebrovascular Integrity Via Cyclophilin A.” Nature 485 (7399): 512-516

Gaengel, K., G. Genové, A. Armulik, and C. Betsholtz. 2009. “Endothelial-Mural Cell Signaling in Vascular Development and Angiogenesis.” Arteriosclerosis, Thrombosis, and Vascular Biology 29 (5): 630-638

Rymo, S. F., H. Gerhardt, F. W. Sand, R. Lang, A. Uv, and C. Betsholtz. 2011. “A Two-Way Communication between Microglial Cells and Angiogenic Sprouts Regulates Angiogenesis in Aortic Ring Cultures.” PLoS ONE 6 (1)

Tammela, T., G. Zarkada, E. Wallgard, A. Murtomäki, S. Suchting, M. Wirzenius, M. Waltari, et al. 2008. “Blocking VEGFR-3 Suppresses Angiogenic Sprouting and Vascular Network Formation.” Nature 454 (7204): 656-660

 

New Blood-vessel-generating Stem Cell with Therapeutic Potential

Researchers at the University of Helsinki, Finland, believe they have discovered stem cells that play a decisive role in new blood vessel growth. If researchers learn to isolate and efficiently produce these stem cells found in blood vessel walls, the cells offer new opportunities in the treatment of cardiovascular diseases, cancer and many other diseases. The study is published in the PLOS Biology journal on 16 October 2012.

Recommended Readings: Gerry Rubin, Ph.D.

Friday Lecture Series

Richard M. Furlaud Distinguished Lecture

A Molecular Geneticist’s Approach to Understanding the Fly Brain

Gerry Rubin, Ph.D., vice president and executive director,

Howard Hughes Medical Institute Janelia Farm Research Campus

October 19, 2012

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Aboobaker, A. A., Tomancak, P., Patel, N., Rubin, G. M., & Lai, E. C. (2005). Drosophila microRNAs exhibit diverse spatial expression patterns during embryonic development. Proceedings of the National Academy of Sciences of the United States of America, 102(50), 18017-18022

Ashburner, M., Misra, S., Roote, J., Lewis, S. E., Blazej, R., Davis, T., . . . Rubin, G. M. (1999). An exploration of the sequence of a 2.9-mb region of the genome of drosophila melanogaster: The adh region. Genetics, 153(1), 179-219

Bellen, H. J., Levis, R. W., Liao, G., He, Y., Carlson, J. W., Tsang, G., . . . Spradling, A. C. (2004). The BDGP gene disruption project: Single transposon insertions associated with 40% of drosophila genes. Genetics, 167(2), 761-781

Miklos, G. L. G., & Rubin, G. M. (1996). The role of the genome project in determining gene function: Insights from model organisms. Cell, 86(4), 521-529

Pfeiffer, B. D., Jenett, A., Hammonds, A. S., Ngo, T. -. B., Misra, S., Murphy, C., . . . Rubin, G. M. (2008). Tools for neuroanatomy and neurogenetics in drosophila. Proceedings of the National Academy of Sciences of the United States of America, 105(28), 9715-9720

Pfeiffer, B. D., Ngo, T. -. B., Hibbard, K. L., Murphy, C., Jenett, A., Truman, J. W., & Rubin, G. M. (2010). Refinement of tools for targeted gene expression in drosophila. Genetics, 186(2), 735-755

 

Recommended Readings: Robert Johnston, Jr. PhD Dec 10, 2012

Controlling Stochastic Gene Expression in the Drosophila retina

Robert Johnston, Jr.   PhD

Postdoctoral Fellow

Department of Biology, Center for Developmental Genetics

New York University

Monday, December 10,  2012

4 p.m. , Caspary Auditorium.   Refreshments 3:45 p.m.

Recommended Readings:

Sood, P; Johnston, RJ Jr.;Kusssell, E.  2012.  Stochastic de-repression of rhodopsins in single photoreceptors of the fly retina.  PLoS Computational Biology.  8(2):e1002357.  DOI:10.1371/journal.pcbi.1002357

Johnson, RJ, Jr.; Desplan, C.  2010.  Stochastic mechanisms of cell fate specification that yield random or robust outcomes.  Annual Review of Cell and Developmental Biology.  26:689-719.  DOI:10.1146/annurev-cellbio-100109-104113

Jukam, D; Desplan, C.  2010.  Binary date decisions in differentiating neurons.  Current Opinion in Neurobiology.  20(1):6-13.  DOI:10.1016/j.conb.2009.11.002

Wenet, MF; Mazzoni, EO; Ceclik A; et al.  2006.  Stochastic spineless expression creates the retinal mosaic for colour vision.  NATURE.  440(7081):174-180.  DOI:10.1038/nature04615

Bell, ML; Earl, JB; Britt, SG.  2007.  Two types of Drosophila R7 photoreceptor cells are arranged randomly: a model for stochastic cell-fate determination.  Journal of Comparative Neurology. 502(1):75-85.  DOI:10.1002/cne.21298.

Chanas, SA; Collinson, JM; Ramaesh, T; et al.  2009.  Effects of elevated Pax6 expression and genetic background on mouse eye development.  Investigative Ophthalmology and Visual Science.  50(9):4045-4059.  DOI:10-1167/iovs.07-1630

Johnson, RJ Jr.; Desplan, C.  2008.  Stochastic neuronal cell fate choices.  Current Opinion in Neurobiology.  18(1):20-27.  DOI:10.1016/j.conb.2008.04.004

Recommended Readings: Leslie M Turner PhD Oct 22, 2012

Genomic Networks of Hybrid Sterility

Leslie M Turner  PhD

Postdoctoral Fellow

Laboratory of Genetics, University of Wisconsin – Madison

Monday, October 22,  2012

4 p.m. , Caspary Auditorium.   Refreshments 3:45 p.m.

Recommended Readings:

Janousek, V; Wang, LY; Luzynski, K; et al.  2012.  Genome-wide architecture of reproductive isolation in naturally occurring hybrid zone between Mus musculus musculus and M. m. domesticus.   Molecular Ecology.  21(12):3032-3047.  DOI:10.111/j.1365-294X.2012.05583.x

White, MA; Steffy, B; Wiltshire, T; et al.  2011.  Genetic dissection of a key reproductive barrier between nascent species of house mice.  Genetics. 189(1):289-U988.  DOI:10.1534/genetics.111.129171

Turner, LM; Schwahn, DJ; Harr, B.  2012.  Reduced male fertility is common but highly variable in form and severity in a natural house mouse hybrid zone.   Evolution.  66(2):443-458 DOI:10.1111/j.1558-5646.2011.01445.x

Turner, LM; Young, AR; Roempler, H; et al.  2010.  Monogamy evolves through multiple mechanisms: evidence from V1aR in deer mice.  Molecular Biology and Evolution.  27(6)1269-1278.  DOI:10.1093/molbev/msq013

Harr, B; Turner, LM.  2010.  Genome-wide analysis of alternative splicing evolution among Mus subspecies.  Molecular Ecology.  19(suppl 1):228-239.  DOI:10.1111/j.1365-294X.04490.x

Gompert, Z; Buerkle, CA.  2009.  A powerful regression-based method for admixture mapping of isolation across the genome of hybrids.  Molecular Ecology.  18(6):1207-1224.  DOI:10.1111/j.1365-0294X.04098.x

Elliott, RW; Miller, DR; Pearsall, RS; et al.  2001.  Genetic analysis of testis weight and fertility in an interspecies hybrid congenic strain for chromosome X.   Mammalian Genome.  12(1):45-51.  DOI:10.1007/s003350010234

Recommended Readings: Robert Lefkowitz, M.D.

Friday Lecture Series

Seven Transmembrane Receptors

Robert Lefkowitz, M.D., James B. Duke Professor of Medicine, Duke University

Medical Center,and investigator, Howard Hughes Medical Institute

October 12, 2012

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Chen, M., Philipp, M., Wang, J., Premont, R. T., Garrison, T. R., Caron, M. G., . . . Chen, W. (2009). G protein-coupled receptor kinases phosphorylate LRP6 in the wnt pathway. Journal of Biological Chemistry, 284(50), 35040-35048

Rajagopal, S., Ahn, S., Rominger, D. H., Gowen-MacDonald, W., Lam, C. M., DeWire, S. M., . . . Lefkowitz, R. J. (2011). Quantifying ligand bias at seven-transmembrane receptors. Molecular Pharmacology, 80(3), 367-377

Rajagopal, S., Kim, J., Ahn, S., Craig, S., Lam, C. M., Gerard, N. P., . . . Lefkowitz, R. J. (2010). β-Arrestin- but not G protein-mediated signaling by the “decoy” receptor CXCR7. Proceedings of the National Academy of Sciences of the United States of America, 107(2), 628-632

Rajagopal, S., Rajagopal, K., & Lefkowitz, R. J. (2010). Teaching old receptors new tricks: Biasing seven-transmembrane receptors. Nature Reviews Drug Discovery, 9(5), 373-386

Rockman, H. A., & Lefkowitz, R. J. (2011). Introduction to the series on novel aspects of cardiovascular g-protein-coupled receptor signaling. Circulation Research, 109(2), 202-204

 

Recommended Readings: Paul Steinhardt, Ph.D.

Friday Lecture Series

Once Upon a Time in Kamchatka: The Extraordinary Search for Natural Quasicrystals

Paul Steinhardt, Ph.D., Albert Einstein Professor in Science and director,

Princeton Center for Theoretical Science,

Princeton University

October 5, 2012

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Bindi, L., J. M. Eiler, Y. Guan, L. S. Hollister, G. MacPherson, P. J. Steinhardt, and N. Yao. 2012. Evidence for the Extraterrestrial Origin of a Natural Quasicrystal.  Proceedings of the National Academy of Sciences of the United States of America 109 (5): 1396-1401

Florescu, M., S. Torquato, and P. J. Steinhardt. 2009. Complete Band Gaps in Two-Dimensional Photonic Quasicrystals. Physical Review B – Condensed Matter and Materials Physics 80 (15)

Rechtsman, M. C., H. -C Jeong, P. M. Chaikin, S. Torquato, and P. J. Steinhardt. 2008. Optimized Structures for Photonic Quasicrystals. Physical Review Letters 101 (7)

Steinhardt, P. J. 2008. Solid-State Physics: How does Your Quasicrystal Grow? Nature 452 (7183): 43-44

Steinhardt, P. J. and L. Bindi. 2012. In Search of Natural Quasicrystals. Reports on Progress in Physics 75 (9)

Steinhardt, P. J.  2011. Once upon a Time in Kamchatka: The Search for Natural Quasicrystals. Philosophical Magazine 91 (19-21): 2421-2426