Recommended Readings: Howard C Hang, PhD.

Chemical Reporters for Exploring Posttranslational

Modifications in Innate Immunity

Howard C Hang, Ph.D.

Laboratory of Chemical Biology and Microbial Pathogenesis

The Rockefeller University

4:00 p.m. Monday, June 4, 2012    Refreshments  3:45  Abby Lounge

Caspary Auditorium

Recommended Readings

Yount JS, Charron G, Hang HC.   2012.  Bioorthogonal proteomics of 15-hexadecynyloxyacetic acid chemical reporter reveals preferential targeting of fatty acid modified proteins and biosynthetis enzymes.    Bioorganic & Medicinal Chemistry.  20(2, S1):650-654.  DOI: 0.1016/j.bmc.2011.03.062

Lei YL, Xie K. et al.  2012.  Chemistry-based functional proteomics to identify novel deubiquitylating enzymes involved in viral infection.   Combinatorial Chemistry & High Throughput Screening.  15(4):316-327.   Please request from Markus Library.

Grammel M, Dossa PD, Taylor-Salmon E, et al.  2012.  II-selective labeling of bacterial proteomes with an  orthogonal phenylalanine amino acid reporter.   Chemical Communications.  48(10):1473-1474.  DOI: 10.1039/c1cc14939c

Aguera-Gonzales S, Gross CC, Fernandez-Messina L, et al.  2011.  Palmitoylation of MICA, a ligand for NKG2D, mediates its recruitment to membrane microdomains and promotes its shedding   European Journal of Immunology.  41(12):3667-3676.   DOI: 10.1002/eji.20114165

Hao ZY, Hong SL, Chen X, et al.  2011.  Introducing bioorthogonal functionalities into proteins in living cellsAccounts of Chemical Research   44(9, S1):742-751.   DOI: 10.1021/ar200067r

Hang HC, Linder ME.  2011.  Exploring protein lipidation with chemical biology.  Chemical Reviews.  111(10):6341-6358.   DOI:  10.1021/cr2001977

Yang YY, Hang HC.  2011.  Chemical approaches for the detection and synthesis of acetylated proteins.  Chembiochem.   12(2):314-322.   DOI: 10.1002/cbc.201000558




Recommended Readings: Sydney Brenner, D.Phil.

Friday Lecture Series

Reading the Human Genome

Sydney Brenner, D.Phil., senior distinguished fellow,

Crick-Jacobs Center Brenner Laboratory, Salk Institute

May 18, 2012

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium


Recommended Readings

Brenner, S. (2010). Sequences and consequences. Philosophical Transactions of the Royal Society B: Biological Sciences, 365(1537), 207-212

Brenner, S. (2012). Turing centenary: Life’s code script. Nature, 482(7386), 461

Gilligan, P., Brenner, S., & Venkatesh, B. (2002). Fugu and human sequence comparison identifies novel human genes and conserved non-coding sequences. Gene, 294(1-2), 35-44

Gwee, P., Amemiya, C. T., Brenner, S., & Venkatesh, B. (2008). Sequence and organization of coelacanth neurohypophysial hormone genes: Evolutionary history of the vertebrate neurohypophysial hormone gene locus. BMC Evolutionary Biology, 8(1)

Lee, A. P., Yang, Y., Brenner, S., & Venkatesh, B. (2007). TFCONES: A database of vertebrate transcription factor-encoding genes and their associated conserved noncoding elements. BMC Genomics, 8

Ruhe, J. E., Streit, S., Hart, S., Wong, C., Specht, K., Knyazev, P., Ullrich, A. (2007). Genetic alterations in the tyrosine kinase transcriptome of human cancer cell lines. Cancer Research, 67(23), 11368-11376

Venkatesh, B., Kirkness, E. F., Loh, Y., Halpern, A. L., Lee, A. P., Johnson, J., . . . Brenner, S. (2006). Ancient noncoding elements conserved in the human genome. Science, 314(5807), 1892


Biologists Produce Malaria Vaccine From Algae

Biologists at the University of California, San Diego have succeeded in engineering algae to produce potential candidates for a vaccine that would prevent transmission of the parasite that causes malaria, an achievement that could pave the way for the development of an inexpensive way to protect billions of people from one of the world’s most prevalent and debilitating diseases. Initial proof-of-principle experiments suggest that such a vaccine could prevent malaria transmission.   Read the report of their research in PLoS ONE.