Recommended Readings: Anne Ephrussi, Ph.D.

Friday Lecture Series

RNP Assembly and Transport in the Drosophila Oocyte

Anne Ephrussi, Ph.D., head, Developmental Biology Unit and head,

International Center for Advanced Training,

European Molecular Biology Laboratory

April 20, 2012

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium


Recommended Readings:

Chekulaeva, M. and A. Ephrussi. 2004. “Drosophila Development: RNA Interference Ab Ovo.” Current Biology 14 (11): R428-R430

Hachet, O. and A. Ephrussi. 2001. “Drosophila Y14 Shuttles to the Posterior of the Oocyte and is Required for Oskar mRNA Transport.” Current Biology 11 (21): 1666-1674

Jambor, H., C. Brunel, and A. Ephrussi. 2011. “Dimerization of Oskar 3′ UTRs Promotes Hitchhiking for RNA Localization in the Drosophila Oocyte.” RNA 17 (12): 2049-2057

Krauss, J., S. López de Quinto, C. Nüsslein-Volhard, and A. Ephrussi. 2009. “Myosin-V Regulates Oskar mRNA Localization in the Drosophila Oocyte.” Current Biology 19 (12): 1058-1063

Vanzo, N., A. Oprins, D. Xanthakis, A. Ephrussi, and C. Rabouille. 2007. “Stimulation of Endocytosis and Actin Dynamics by Oskar Polarizes the Drosophila Oocyte.” Developmental Cell 12 (4): 543-555

Vanzo, N. F. and A. Ephrussi. 2002. “Oskar Anchoring Restricts Pole Plasm Formation to the Posterior of the Drosophila Oocyte.” Development 129 (15): 3705-3714

Delivering Paricles Directly Into Cells

Scientists who developed a technology for identifying and targeting unique protein receptor ZIP Codes on the cellular surface have found a way to penetrate the outer membrane and deliver engineered particles — called iPhage — to organelles inside the cell. 

In a paper recently published online in Nature Communications, the team led by researchers at The University of Texas MD Anderson Cancer Center reports packaging the phage particles with a peptide called penetratin to reach inside the cell.

Recommended Readings: Bruce Walker, M.D.

Friday Lecture Series

Immune Control and Immune Failure in HIV Infection

Bruce Walker, M.D., Principal Investigator,

Ragon Institute of MGH, MIT and Harvard

April 13, 2012

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium


Recommended Readings:

Huang, J., P. S. Burke, T. D. H. Cung, F. Pereyra, I. Toth, B. D. Walker, L. Borges, M. Lichterfeld, and X. G. Yu. 2010. “Leukocyte Immunoglobulin-Like Receptors Maintain Unique Antigen-Presenting Properties of Circulating Myeloid Dendritic Cells in HIV-1-Infected Elite Controllers.” Journal of Virology 84 (18): 9463-9471

Kawashima, Y., K. Pfafferott, J. Frater, P. Matthews, R. Payne, M. Addo, H. Gatanaga, et al. 2009. “Adaptation of HIV-1 to Human Leukocyte Antigen Class I.” Nature 458 (7238): 641-645

Mahalanabis, M., P. Jayaraman, T. Miura, F. Pereyra, E. M. Chester, B. Richardson, B. Walker, and N. L. Haigwood. 2009. “Continuous Viral Escape and Selection by Autologous Neutralizing Antibodies in Drug-Naïve Human Immunodeficiency Virus Controllers.” Journal of Virology 83 (2): 662-672

Matthews, P. C., A. Prendergast, A. Leslie, H. Crawford, R. Payne, C. Rousseau, M. Rolland, et al. 2008. “Central Role of Reverting Mutations in HLA Associations with Human Immunodeficiency Virus Set Point.” Journal of Virology 82 (17): 8548-8559

Pereyra, F., S. Palmer, T. Miura, B. L. Block, A. Wiegand, A. C. Rothchild, B. Baker, et al. 2009. “Persistent Low-Level Viremia in HIV-1 Elite Controllers and Relationship to Immunologic Parameters.” Journal of Infectious Diseases 200 (6): 984-990

Virgin, H. W. and B. D. Walker. 2010. “Immunology and the Elusive AIDS Vaccine.” Nature 464 (7286): 224-231

Recommended Readings: Sheetz, M., Kenan, W., Spudich, J., and Vale, R.

Friday Lecture Series

Wiley Prize in Biomedical Sciences

Biological Motility and Mechanotransduction

Michael Sheetz, Ph.D., William R. Kenan Jr. Professor,Columbia University, 

Myosin Pulling and Mechanotransduction

James Spudich, Ph.D., professor of biochemistry, Stanford School of Medicine, Hypertrophic and Dilated Cardiomyopathies:

Single Molecule Analysis of Human Cardiac Myosin

Ronald Vale, Ph.D., professor, University of California, San Francisco; investigator, Howard Hughes Medical Institute (HHMI),

Structure and Mechanism of the Dynein Motor Protein

April 6, 2012

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium


Recommended Readings:

Carter, A. P., C. Cho, L. Jin, and R. D. Vale. 2011. “Crystal Structure of the Dynein Motor Domain.” Science 331 (6021): 1159-1165

Chuan, P., J. A. Spudich, and A. R. Dunn. 2011. “Robust Mechanosensing and Tension Generation by Myosin VI.” Journal of Molecular Biology 405 (1): 105-112

Hartman, M. A., D. Finan, S. Sivaramakrishnan, and J. A. Spudich. 2011. Principles of Unconventional Myosin Function and Targeting. Annual Review of Cell and Developmental Biology. Vol. 27: 133-155

Kardon, J. R. and R. D. Vale. 2009. “Regulators of the Cytoplasmic Dynein Motor.” Nature Reviews Molecular Cell Biology 10 (12): 854-865

Vogel, V. and M. Sheetz. 2006. “Local Force and Geometry Sensing Regulate Cell Functions.” Nature Reviews Molecular Cell Biology 7 (4): 265-275

Vogel, V. and M. P. Sheetz. 2009. “Cell Fate Regulation by Coupling Mechanical Cycles to Biochemical Signaling Pathways.” Current Opinion in Cell Biology 21 (1): 38-46