Recommended Readings: Elaine Fuchs, Ph.D.

Friday Lecture Series

Skin Stem Cells: In Morphogenesis, Wound Repair and Cancer

Elaine Fuchs, Ph.D., Rebecca C. Lancefield Professor,

The Rockefeller University

March 2, 2012

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium


Recommended Readings:

Blanpain, C., and E. Fuchs. 2009. Epidermal homeostasis: A balancing act of stem cells in the skin. Nature Reviews Molecular Cell Biology 10, (3): 207-217

Ezhkova, E., W. -H Lien, N. Stokes, H. A. Pasolli, J. M. Silva, and E. Fuchs. 2011. EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair. Genes and Development 25, (5): 485-498

Fuchs, E. 2007. Scratching the surface of skin development. Nature 445, (7130): 834-842

Guasch, G., M. Schober, H. A. Pasolli, E. B. Conn, L. Polak, and E. Fuchs. 2007. Loss of TGFβ signaling destabilizes homeostasis and promotes squamous cell carcinomas in stratified epithelia. Cancer Cell 12, (4): 313-327

Kobielak, A., and E. Fuchs. 2006. Links between α-catenin, NF-κB, and squamous cell carcinoma in skin. Proceedings of the National Academy of Sciences of the United States of America 103, (7): 2322-2327

Williams, S. E., S. Beronja, H. A. Pasolli, and E. Fuchs. 2011. Asymmetric cell divisions promote notch-dependent epidermal differentiation. Nature 470, (7334): 353-358

Yi, R., and E. Fuchs. 2010. MicroRNA-mediated control in the skin. Cell death and differentiation 17, (2): 229-235

Recommended Readings: Tiago Branco M.D, Ph.D. Monday, March 12, 2012

Dendritic Computation in Cortical Pyramidal Cells

Tiago Branco, M.D, Ph.D.

Postdoctoral Research Associate

Wolfson Institute for Biomedical Research

University College London

4:00 p.m. Monday, March 12, 2012   refreshments 3:45 p.m.

Caspary Auditorium

Recommended Readings:

Takahashi N: Kitamura K; Matsuo N; et al.  2012.  Locally synchronized synaptic inputs. Science.  335(6066):353-356.  DOI:10.1126/science.1210362

George GA; Lyons-Warren AM; Ma XF; et al.  2011.  A diversity of synaptic filters are created by temporal summation of excitation and inhibition.  Journal of Neuroscience.  31(41):14721-14734.  DOI:10.1523/JNEUROSCI.1424-11.2011

Branco T.  2011.  The language of dendrites.   Science. 334(6056):615-616. DOI: 10.1126/science.1215079   

Branco T: Haeusser M.  2011.  Synaptic integration gradients in single cortical pyramidal sequences in cortical neurons.  Neuron. 69(5):885-895.  DOI:10.1016/j.neuron.2011.02.006

Branco T: Clark BA; Haeusser M.  2010.  Dendritic discrimination of temporal input sequences in cortical neurons.  Science.  329(5999):1671-1675.  DOI:10:1126/science.1189664

Branco T; Haeusser M.  2010.  The single dendritic branch as a fundamental functional unit in the nervous system. Current Opinion in Neurobiology.  20(4):494-502.  DOI:10.1016/j.conb.2010.07.009

Branco T; Staras K; Darcy KJ.; et al.  2008.  Local dendritic activity sets release probability at hippocampal synapses.  Neuron.  59(3):475-485.   DOI:10.1016/j.neuron.2008.07.006.

Recommended Readings: Hani S. Zaher, PH.D. Monday, March 5, 2012

Dealing with Mistakes: a New Form of Proofreading on the Ribosome

Hani S. Zaher, Ph.D

Postdoctoral Fellow

Department of Molecular Biology and Genetics

Johns Hopkins School of Medicine

4:00 p.m.  Monday, March 5, 2012   Refreshments at 3:45

Caspary Auditorium

Recommended Readings:

Zaher HS; Shaw JJ; Strobel SA; et al.  2011.  The 2’-OH group of the peptidyl-tRNA stabilizes an active conformation of the ribosomal PTCEMBO Journal.   30(12):2445-2453.   DOI:10.1038/emboj.2011.142

Zaher HS; Green R.  2011.  A primary role for release factor 3 in quality control during translation eloncation in Escherichia coli.  CELL.  147(2):396-408.   DOI:10.1016/j.cell.2011.08.45

Zaher HS; Green R.  2010.  Kinetic basis for global loss of fidelity arising from mismatches in the P-site codon:anticodon helix.   RNA-A Publication of the RNA Society.  16(10):1980-1989.  DOI:10.1261/rna.2241810.

Zaher HS; Green R.  2010.  Hyperaccurate and error-prone ribosomes exploit distinct mechanisms during tRFNA selectionMolecular Cell   39(1):110-120.   DOI:10.1016/j.molcel.2010.06.009

Zaher HS; Green R. 2009.  Fidelity at the molecular level: lessons from protein synthesis.   CELL.  136(4):746-762.  DOI:10.1016/j.cell.2009.01.036

Zaher HS; Green R.  2009.  Quality control by the ribosome following peptide bond formation.  NATURE.  457(7226):161-U51.   DOI:10.1038/nature07582

Recommended Readings: Hopi Hoekstra, Ph.D.

Friday Lecture Series

From Darwin to DNA: The Genetic Basis of Adaptive Morphology and Behavior

Hopi Hoekstra, Ph.D., Alexander Agassiz Professor of Zoology,

curator of mammals, Museum of Comparative Zoology,

Harvard University

February 24, 2012

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium


Recommended Readings:

Abzhanov, A., C. G. Extavour, A. Groover, S. A. Hodges, H. E. Hoekstra, E. M. Kramer, and A. Monteiro. 2008. Are we there yet? tracking the development of new model systems. Trends in Genetics 24, (7): 353-360

Barrett, R. D. H., and H. E. Hoekstra. 2011. Molecular spandrels: Tests of adaptation at the genetic level. Nature Reviews Genetics 12, (11): 767-780

Hoekstra, H. E. 2006. Genetics, development and evolution of adaptive pigmentation in vertebrates. Heredity 97, (3): 222-234

Hoekstra, H. E., and J. A. Coyne. 2007. The locus of evolution: Evo devo and the genetics of adaptation. Evolution 61, (5): 995-1016

Stinchcombe, J. R., and H. E. Hoekstra. 2008. Combining population genomics and quantitative genetics: Finding the genes underlying ecologically important traits. Heredity 100, (2): 158-170

Recommended Readings: Kai Simmons, M.D.

Friday Lecture Series

Lipids Organizing Cell Membranes

Kai Simons, M.D., research group leader and director emeritus,

Max Planck Institute of Molecular Cell Biology and Genetics

February 17, 2012

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium


Recommended Readings:

Coskun, U., and K. Simons. 2011. Cell membranes: The lipid perspective. Structure 19, (11): 1543-1548

Levental, I., M. Grzybek, and K. Simons. 2010. Greasing their way: Lipid modifications determine protein association with membrane rafts. Biochemistry 49, (30): 6305-6316

Lingwood, D., and K. Simons. 2010. Lipid rafts as a membrane-organizing principle. Science 327, (5961): 46-50

Shevchenko, A., and K. Simons. 2010. Lipidomics: Coming to grips with lipid diversity. Nature Reviews Molecular Cell Biology 11, (8): 593-598

Simons, K., and M. J. Gerl. 2010. Revitalizing membrane rafts: New tools and insights. Nature Reviews Molecular Cell Biology 11, (10): 688-699

Recommended Readings: Howard Chang, M.D., Ph.D.

Friday Lecture Series

Genome Regulation by Long Noncoding RNA

Howard Chang, M.D., Ph.D., early career scientist,

Howard Hughes Medical Institute; professor of dermatology,

Stanford University School of Medicine, member, Stanford Cancer Center and Stanford Institute for Stem Cell Biology and Regenerative Medicine

February 10, 2012

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium


Recommended Readings:

Hung, T., Y. Wang, M. F. Lin, A. K. Koegel, Y. Kotake, G. D. Grant, H. M. Horlings, et al. 2011. Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters. Nature genetics 43, (7): 621-629

Rinn, J. L., M. Kertesz, J. K. Wang, S. L. Squazzo, X. Xu, S. A. Brugmann, L. H. Goodnough, et al. 2007. Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs. Cell 129, (7): 1311-1323

Tsai, M. -C, O. Manor, Y. Wan, N. Mosammaparast, J. K. Wang, F. Lan, Y. Shi, E. Segal, and H. Y. Chang. 2010. Long noncoding RNA as modular scaffold of histone modification complexes. Science 329, (5992): 689-693

Wang, K., and H. Chang. 2011. Molecular mechanisms of long noncoding RNAs. Molecular cell 43, (6): 904-914

Wang, K. C., Y. W. Yang, B. Liu, A. Sanyal, R. Corces-Zimmerman, Y. Chen, B. R. Lajoie, et al. 2011. A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression. Nature 472, (7341): 120-126


Recommended Readings: Mitchell Guttman, Monday, February 27, 2012

Monday lecture Series

Functional Integration of Large ncRNAs in the Molecular

Circuitry Controlling Cell State

Mitchell Guttman

Graduate Fellow

Broad Institute of MIT and Harvard

   Massachusetts Institute of Technology

Monday, February 27, 2012

4 p.m, Caspary Auditorium.   Refreshments 3:45 p.m.

Recommended Readings:

Yang, LG; Lin CR; Rosebfeld MG. 2011.  A lincRNA switch for embryonic stem cell fate.  Cell Research  21(12):1646-1648.  DOI:10.1038/cr.2011.166

Guttman M; Donachey J; Carey BW; et al. 2011.  lincRNAs act in the circuitry controlling pluripotency and differentiation.  NATURE.  477(7364):295-U60.   DOI:10.1038/nature10398

Loewer S; Cabili MN; Guttman M: et al.  2010.  Large intergenic non-coding RNA-RoR modeulates reprogramming of human induced pluripotent stem cells.  NATURE Genetics.  42(12):1113-   DOI: 10.1038/ng.710

Huarte M; Guttman M; Feldser D; et al.  2010.  A large intergenic noncoding RNA induced by p53 mediates global gene repression in thep53 response. Cell.  142(3):409-419.   DOI:10.1016/j.cell.2010.06.040

Guttman, M; Garber M; Levin JZ; et al.  2010.  Ab initio reconstruction of cell type-specific transcriptomes in mouse reveals the conserved multi-exonic structure of lincRNAs.  NATURE Biotechnology.  28(5):503-U166.  DOI: 10.1038/nbt.1633

Khalil AM; Guttman M; Huarte M; et al.  2009.  Many human large intergenic noncoding RNAs associate with Chromatin-modifying complexes and affect gene expression.  PNAS.  106(28):11667-11672   DOI: 10.1073/pnas.0904715106

Guttman M; Amit I; Garber M; et al.  2009.  Chromatin signature reveals over a thousand highly conserved large no-coding RNAs in mammals.  NATURE.  458(7235):223-227.  DOI: 10.1038/nature07672


New Research on Antagonistic Coevolution

Biologists have found new evidence for why mice, people and other vertebrate animals carry thousands of varieties of genes to make immune-system proteins named MHCs — even though some of those genes make us susceptible to infections and to autoimmune diseases.  Findings are published in the Feb 6, 2012 issue of PNAS.

Recommended Readings: Jesse Goldberg M.D., Ph.D. February 15, 2012

Monday lecture Series

Neural Circuits UnderlyinG Motor Exploration During Learning

Jesse Goldberg

Postdoctoral Fellow

McGovern Institute for Brain Research

   Massachusetts General Hospital

Wednesday, February 15  2012

4 p.m. , Caspary Auditorium.   Refreshments 3:45 p.m.

Recommended Readings:

Bouvrie J; Slotine JJ.  2011.  Synchronization and redundancy: Implications for robustness of neural learning and decision making.  Neural Computation.  23(11):2915-2941.

Fee M; Goldberg JH. 2011.  A hypothesis for basal ganglia-dependent reinforcement learning in the songbirdNeuroscience.  198 (S1):152-170.  DOI: 10.1016/j.neuroscience.2011.09.069

Shmuelof L; Krakauer JW.  2011.  Are we ready for a natural history of motor learning?  Neuron. 72(3):469-476. 

Goldberg JJ; Fee MS.  2011.  Vocal babbling in songbirds requires the basal ganglia-recipient motor thalamus but not the basal ganglia.  Journal of Neurophysiology.  105(6):2729-2739. 

Oelveczky BP; Otchy TM; Goldberg JH; et al.   2011.  Changes in the neural control of a complex motor sequence during learning.  Journal of Neurophysiology.  106(1):386-397.   DOI: 10.1152/jn.00018.2011

Thompson JA; Basista MJ; We W; et al.  2011.  Dual Pre-motor contribution to songbird syllable variation  Journal of Neuroscience.  31(1):322-330.  DOI:10.1523/JNEUROSCI.5967-09.2011

Goldberg JH; Adler A; Bergman H; et al.  2010.  Singing-related neural activity distinguishes two putative pallidal cell types in the songbird basal ganglia: Comparison to the primate internal and external pallidal segments. Journal of Neuroscience.  30(20):7088-7098.   DOI:10.1523/JNEUROSCI.0168-10.2010