Recommended Readings: Brenda Milner, Ph.D., CC

Friday Lecture Series

Reflecting on the Field of Brain and Memory

Brenda Milner, Ph.D., CC,

The Dorothy J. Killam Professor of Neurology and Neurosurgery,

Montreal Neurological Institute, McGill University

December 2,  2011

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings:

Klein, D., R. J. Zatorre, J. -K Chen, B. Milner, J. Crane, P. Belin, and M. Bouffard. 2006. Bilingual brain organization: A functional magnetic resonance adaptation study. NeuroImage 31, (1): 366-375

Köhler, S., J. Crane, and B. Milner. 2002. Differential contributions of the parahippocampal place area the anterior hippocampus to human memory for scenes. Hippocampus 12, (6): 718-723

Köhler, S., T. Paus, R. L. Buckner, and B. Milner. 2004. Effects of left inferior prefrontal stimulation on episodic memory formation: A two-stage fMRI-rTMS study. Journal of cognitive neuroscience 16, (2): 178-188

Milner, B. 1997. Right medial temporal-lobe contribution to object-location memory. Philosophical Transactions of the Royal Society B: Biological Sciences 352, (1360): 1469-1474

Milner, B., L. R. Squire, and E. R. Kandel. 1998. Cognitive neuroscience and the study of memory. Neuron 20, (3): 445-468

Recommended Readings: Peter Reddien, Ph.D.

Friday Lecture Series

The Cellular and Molecular Basis for Planarian Regeneration


Peter Reddien, Ph.D., early career scientist,

Howard Hughes Medical Institute, member,

Whitehead Institute, and

Cabot Career Development Associate Professor of Biology,

Massachusetts Institute of Technology

November 18,  2011

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings:

Petersen, C. P., and P. W. Reddien. 2008. Smed-βcatenin-1 is required for anteroposterior blastema polarity in planarian regeneration. Science 319, (5861): 327-330

Reddien, P. W., N. J. Oviedo, J. R. Jennings, J. C. Jenkin, and A. Sánchez Alvarado. 2005. Developmental biology: SMEDWI-2 is a PIWI-like protein that regulates planarian stem cells. Science 310, (5752): 1327-1330

Reddien, P. W., and Sánchez Alvarado, A. Fundamentals of planarian regeneration.2004. Annual Review of Cell and Developmental Biology Vol. 20: 725-757

Scimone, M. L., M. Srivastava, G. W. Bell, and P. W. Reddien. 2011. A regulatory program for excretory system regeneration in planarians. Development 138, (20): 4387-4398

Wagner, D. E., I. E. Wang, and P. W. Reddien. 2011. Clonogenic neoblasts are pluripotent adult stem cells that underlie planarian regeneration. Science 332, (6031): 811-816

Wenemoser, D., and P. W. Reddien. 2010. Planarian regeneration involves distinct stem cell responses to wounds and tissue absence. Developmental biology 344, (2): 979-991

 

Recommended Readings: Olaf Schneewind, M.D., Ph.D.

Friday Lecture Series

Ernst A.H. Friedheim Memorial Lecture

Envelope Assembly and Function in Bacterial Pathogens

Olaf Schneewind, M.D., Ph.D.,

Louis Block Professor and chair, department of microbiology,

University of Chicago

November 11,  2011

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings:

Cheng, A. G., M. McAdow, H. K. Kim, T. Bae, D. M. Missiakas, and O. Schneewind. 2010. Contribution of coagulases towards staphylococcus aureus disease and protective immunity. PLoS Pathogens 6, (8): 19-20

Hendrickx, A. P. A., J. M. Budzik, S. -Y Oh, and O. Schneewind. 2011. Architects at the bacterial surface-sortases and the assembly of pili with isopeptide bonds. Nature Reviews Microbiology 9, (3): 166-171

Kern, J., and O. Schneewind. 2010. BslA, the S-layer adhesin of B. anthracis, is a virulence factor for anthrax pathogenesis. Molecular microbiology 75, (2): 324-332

Kim, H. K., A. G. Cheng, H. -Y Kim, D. M. Missiakas, and O. Schneewind. 2010. Nontoxigenic protein A vaccine for methicillin-resistant staphylococcus aureus infections in mice. Journal of Experimental Medicine 207, (9): 1863-1870

Kim, H. K., A. DeDent, A. G. Cheng, M. McAdow, F. Bagnoli, D. M. Missiakas, and O. Schneewind. 2010. IsdA and IsdB antibodies protect mice against staphylococcus aureus abscess formation and lethal challenge. Vaccine 28, (38): 6382-6392

Schneewind, O., and D. Missiakas. 2011. Structural vaccinology to thwart antigenic variation in microbial pathogens. Proceedings of the National Academy of Sciences of the United States of America 108, (25): 10029-10030

Thammavongsa, V., J. W. Kern, D. M. Missiakas, and O. Schneewind. 2009. Staphylococcus aureus synthesizes adenosine to escape host immune responses. Journal of Experimental Medicine 206, (11): 2417-2427

NAS Report Calls for Creation of a Biomedical Research and Patient Data Network

WASHINGTON — A new data network that integrates emerging research on the molecular makeup of diseases with clinical data on individual patients could drive the development of a more accurate classification of disease and ultimately enhance diagnosis and treatment, says a new report from the National Research Council.  The “new taxonomy” that emerges would define diseases by their underlying molecular causes and other factors in addition to their traditional physical signs and symptoms.  The report adds that the new data network could also improve biomedical research by enabling scientists to access patients’ information during treatment while still protecting their rights.  This would allow the marriage of molecular research and clinical data at the point of care, as opposed to research information continuing to reside primarily in academia.

A Fresh Look At The Validity Of Current Understanding Of Alzheimer’s Disease

For decades the amyloid hypothesis has dominated the research field in Alzheimer’s disease. The theory describes how an increase in secreted beta-amyloid peptides leads to the formation of plaques, toxic clusters of damaged proteins between cells, which eventually result in neurodegeneration. Scientists at Lund University, Sweden, have now presented a study that turns this premise on its head. The research group’s data offers an opposite hypothesis, suggesting that it is in fact the neurons’ inability to secrete beta-amyloid that is at the heart of pathogenesis in Alzheimer’s disease.  Read the report of their work in Journal of Neuroscience.

Recommended Readings: Brenda Milner, Ph.D., CC

Friday Lecture Series

Reflecting on the Field of Brain and Memory

Brenda Milner, Ph.D., CC,

The Dorothy J. Killam Professor of Neurology and Neurosurgery,

Montreal Neurological Institute, McGill University

November 4,  2011

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings:

Klein, D., B. Milner, R. J. Zatorre, E. Meyer, and A. C. Evans. 1995. The neural substrates underlying word generation: A bilingual functional- imaging study. Proceedings of the National Academy of Sciences of the United States of America 92, (7): 2899-2903

Klein, D., K. E. Watkins, R. J. Zatorre, and B. Milner. 2006. Word and nonword repetition in bilingual subjects: A PET study. Human brain mapping 27, (2): 153-161

Klein, D., R. J. Zatorre, B. Milner, E. Meyer, and A. C. Evans. 1994. Left putaminal activation when speaking a second language: Evidence from PET. Neuroreport 5, (17): 2295-2297

Milner, B., L. R. Squire, and E. R. Kandel. 1998. Cognitive neuroscience and the study of memory. Neuron 20, (3): 445-468

Owen, A. M., B. Milner, M. Petrides, and A. C. Evans. 1996. Memory for object features versus memory for object location: A positron-emission tomography study of encoding and retrieval processes. Proceedings of the National Academy of Sciences of the United States of America 93, (17): 9212-9217