Recommended Readings: Barry S. Coller M.D. Monday Sept 26 2011

Monday Lectures

Combing Structure-Based Design and Mass Screening to Probe

 Ligand Binding to Integrin Receptors

Barry S. Coller  M.D.

Vice President for Medical Affairs and Physician-in-Chief

Laboratory of Blood and Vascular Biology

September 26, 2011,  Caspary Auditorium,  4 p.m.

Recommended Readings

Litvinov RI; Barsegov V; Schissler AJ; Fisher AR; Bennett JS; Weisel JW; Shuman H.  2011.  Dissociation of bimolecular αIIβ3-fibrinogen complex under a constant tensile force.   Biophysical Journal.  100(1):165-73.

Lord MS; Cheng B; McCarthy SJ; et al.  2011.  The modulation of platelet adhesion and activation by chitosan through plasma and extracellular matrix proteins.  Biomaterials. 32(28):6655-6662  (Request from Markus Library)

Blue R; Li JH; Steinberg J; et al.  2010.  Effects of limiting extension at the alpha IIb Genu on ligand binding to integrin alpha IIb beta 2.  Journal of Biological Chemistry.  285(23):17604-17613.

Sheldrake HM; Patterson LH.  2009.  Function and antagonism of beta(3) integrins in the development of cancer therapyCurrent Cancer Drug Targets. 9(4):519-540.  (Request from Markus Library)

Basani RB; Zhu H: Thornton MA: et al.  2009.  Species differences in small molecule binding to alpha IIb beta 3 are the result of sequence difference in 2 loops of the alpha IIb beta propeller.   Blood.  113(4):902-910.

Blue R; Kowalska MA; Hirsch J; et al.  2009.  Structural and therapeutic insights from the species specificity and in vivo antithrombotic activity of a novel alpha IIb beta 3 antagonist. Blood  114(1):195-201

Blue R; Murcia M; Karan C; et al.  2008.  Application of high-throughput screening to identify a novel alpha IIb-specific small-molecule inhibitor of alpha IIb 3-mediated platelet interaction with fibrinogen.  Blood.  111(3):1248-1256.

Hynes, RO.  2002.  Integrins: bidirectional, allosteric signaling machinesCell. 110(6):673-687.

MicroRNA Helps Put Turtles “In Their Place”

A new technique for animal classification could quell the long-running debate between paleontologists and molecular biologists as to where turtles belong on the evolutionary tree. While some camps have argued that turtles are closer to crocodilians and birds, researchers at the Mount Desert Island Biological Laboratory in Bar Harbor, Maine; Dartmouth College; and Harvard University have published data in Biology Letters suggesting that turtles are more closely related to tuataras and lizards. The team identified 77 new microRNA families in the Anolis carolinensis lizard genome, four of which are also expressed in Chrysemys picta bellii, the Western painted turtle, leading them to conclude that turtles and lizards have much more in common than previously thought.

Harvard Says the U.S. Government Got “MyPlate” Wrong For Healthy Eating

The Harvard School of Public Health has a few bones to pick with the federal government’s MyPlate healthful-eating icon.

They’ve aired their differences in the newly released (and not-so-catchily named) “Healthy Eating Plate.” The new plate looks a lot like MyPlate but with revisions and add-ons that its creators argue offer a more accurate picture of what nutritious diet should look like.

A press release announcing the new icon contends that USDA’s MyPlate was cooked up with too much input from powerful agricultural interests, whose influence led to MyPlate’s allowing too much space for dairy, red meat, potatoes and refined grains. By contrast, the press release says, the new plate is based on the latest science .

Meet the 2011 MacArthur Fellows

The MacArthur Fellows Program awards unrestricted fellowships to talented individuals who have shown extraordinary originality and dedication in their creative pursuits and a marked capacity for self-direction. There are three criteria for selection of Fellows: exceptional creativity, promise for important future advances based on a track record of significant accomplishment, and potential for the fellowship to facilitate subsequent creative work.

The MacArthur Fellows Program is intended to encourage people of outstanding talent to pursue their own creative, intellectual, and professional inclinations. In keeping with this purpose, the Foundation awards fellowships directly to individuals rather than through institutions. Recipients may be writers, scientists, artists, social scientists, humanists, teachers, entrepreneurs, or those in other fields, with or without institutional affiliations. They may use their fellowship to advance their expertise, engage in bold new work, or, if they wish, to change fields or alter the direction of their careers. 

Meet this year’s awardees.