Biopharmaceuticals: A Positive Role for Tobacco In the Fight Against HIV

Biologically produced medications, such as recombinant insulin or therapeutic antibodies to fight cancer, have become indispensable. Plants are particularly suitable for producing complex active substances. The reason is that these substances can be produced inexpensively and on a large scale in plants. Compared to producing them in animal cells, plants have the advantage that they grow quickly, are easy to look after and can be protected well against damaging influences.

Tobacco has long been a very interesting plant for molecular biologists. It is easy to modify, meaning a foreign gene coding for the pharmaceutical protein can be introduced. In addition, a lot of biomass grows quickly and therefore a greater quantity of the desired  – and safe – active proteins is also produced.   The second challenge, high yield harvesting of protein from the plant leaves, is solved by food industry technologies whic can produce the quality and quantity of proteins suitable for use in clinical studies.    Read more about Medicines from Plants .

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Structure Formed by Strep Protein Can Trigger Toxic Shock

 Infection with some strains of strep turn deadly when a protein found on their surface triggers a widespread inflammatory reaction.  Researchers describe the precise architecture of a superstructure formed when the bacterial protein called M1 links with a host protein, fibrinogen, that is normally involved in clotting blood.  The proteins form scaffolds with M1 joints and fibrinogen struts that assemble into dense superstructures. Frontline immune cells called neutrophils mistake these thick networks for blood clots and overreact, releasing a chemical signal that can dilate vessels to the point where they leak.   Read about this research in NATURE.

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