Project to Map Human Proteins 50% Complete

NEW YORK (GenomeWeb News) – Scientists involved in the Human Protein Atlas are about halfway through their effort to generate and compile data on all known human proteins, members of the team announced recently.

As of mid-November, the group of investigators from Sweden, South Korea, China, and India had reportedly characterized about 10,000 of the 20,000 predicted proteins in the human body. Using genetic data as a guide, the researchers are continuing to put together localization, functional, and other proteomic data for the resource, which they expect to finish in 2015.

The Human Protein Atlas relies on a high-throughput, antibody-based proteomics approach in which genetic sequence information is used to find and develop antibodies against specific protein epitope signature tags.

The project, which is led by researchers at the Royal Institute in Stockholm, Uppsala University, and Lab Surgpath in Mumbai, receives funding from the Knut and Alice Wallenberg Foundation.

Recommended Readings: Jesse Ausubel, M.A. Nov. 15, 2010

Monday Lecture Series

The Census of Marine Life

Jesse Ausubel, M.A.

Program for the Human Environment

The Rockefeller University

Caspary Auditorium,  4:00 pm

November 15, 2010

Recommended Readings:

Pennisi, Elizabeth.  2010.  Seeing deeply into the seas’ biodiversity.   Science.   329:622

O’Dor, R; Miloslavich, P; and Yarincik, K.  2010.  Marine Biodiversity and Biogeography – Regional Comparisons of Global Issues, an Introduction.   PLoS One.  5(8): e11871  

Costello, MJ; Coll, M; Danovaro, R, et al.  2010.  A Census of Marine Biodiversity Knowledge, Resources, and Future Challenges.     PLoS One.   5(8): e12110  

Webb, TJ; Vanden Berghe, E; and O’Dor, R.  2010.  Biodiversity’s Big Wet Secret: The Global Distribution of Marine Biological Records Reveals Chronic Under-Exploration of the Deep Pelagic OceanPLoS One. 2010; 5(8): e10223.

O’Dor, RK; Fennel, K; and Berghe, RV .  2009.  A one ocean model of biodiversity.  Deep-sea research Part II: Tropical Studies in Oceanography.  56(19-20):1816-1823     Request from Markus Library.

Katsunori, Y; Fujikura, D.  2009.  OBIS: the databse of the Census of Marine Life project.  Bulletin of the Plankton Society of Japan.  56(2):155-158  Request from Markus Library.

Miloslavich, P; and Klein, E.   2009.  The world conference on marine biodiversity: Current global trends in marine biodiversity research.   Marine Biodiversity. 39(2):147-152

Yarincik, K. and O’Dr, R.  2005.  The census of marine life: goals, scope and strategyScientia Marina  69(Supple1):201-208

Observing the Formation of Ribosomes

Identifying and observing the molecules that form ribosomes — the cellular factories that build the proteins essential for life — has been a key goal for biologists that had seemed nearly unattainable. But a new Scripps Research study, appearing in the October 29, 2010 issue of Science, yielded pictures of the chemical intermediate steps in ribosome creation.  The Scripps lead team developed a new technique, dubbed discovery single-particle profiling, which dodges a previously frustrating purification problem by allowing successful imaging of unpurified samples.