Recommended Readings: Mary Jeanne Kreek, MD Nov 8 2010

Monday Lecture Series

Translational Research:

Contributions of Gene Variants, Endorphins, and Stress Responsivity to Specific Addictions

Mary Jeanne Kreek, MD

Laboratory of the Biology of Addictive Diseases

The Rockefeller University

November 8, 2010

4:15 p.m.  Caspary Hall

Review Article:

Schwarzer C.   2009.  30 years of dynorphins – New insights on their functions in neuropsychiatric diseases.  PHARMACOLOGY & THERAPEUTICS 123(3):353-370 Please request from Markus Library.

Recommended Articles:

Shin AC, Pistell PJ, Phifer CB, et al.  2010.  Reversible suppression of food reward behavior buy chronic mu-opioid receptor antagonism in the nucleus accumbens. NEUROSCIENCE 170(2): 580-588

Mizoguchi H, Watanabe C, Osada S, et al.   2010.  Lack of a rewarding effect and a locomotor-enhancing effect of the selective mu-opioid receptor agonist amidino-TAPA.  PSYCHOPHARMACOLOGY 212(2): 215-225

Mague SD, Blendy JA.  2010.  OPRM1 SNP (A118G): Involvement in disease development, treatment response, and animal models. DRUG AND ALCOHOL DEPENDENCE 108(3, Special Issue SI): 172-182  Request from Markus Library.

Kreek MJ.  2010.  Overview and historical perspective of four papers presented on research related to the endogenous opioid system.  DRUG AND ALCOHOL DEPENDENCE 10(3,  Special Issue SI): 195-199  Request from Markus Library.

Bruchas MR, Land BB, Chavkin C.  2010.  The dynorphin/kappa opioid system as a modulator of stress-induced and pro-addictive behaviors. BRAIN RESEARCH 1314( Special Issue SI): 44-55

Zhou Y, Proudnikov D, Yuferov V, et al.   2010.  Drug-induced and genetic alterations in stress-responsive systems: Implications for specific addictive diseases. BRAIN RESEARCH 1314(Special Issue SI): 235-252

Kreek MJ, Zhou Y, Butelman ER, et al.  2009.  Opiate and cocaine addiction: from bench to clinic and back to the bench. CURRENT OPINION IN PHARMACOLOGY 9(1): 74-80

Recommended Readings: Otger Campas, PH.D. Oct 25, 2010

Monday Lecture Series

Quantifying Morphogenesis and Morphological Variation

Otger Campas, Ph.D.,

SysCODE Fellow 

School of Engineering and Applied Sciences and Department of Organismic

 and Evolutionary Biology

Harvard University and Harvard Medical School

October 25, 2010

4:00 p.m.  Welch Hall Level Two


Recommended Readings:

Campas, O; Mallarino, R; Herrel, A  et al.  2010.  Scaling and shear transformations capture beak shape variation in Darwin’s finches.  PNAS  107(8): 3356-3360

Van Bocxlaer, B; Schultheiss, R.  2010.  Comparison of morphometric techniques for shapes with few homologous landmarks based on machine-learning approaches to biological discrimination. Paleobiology.  36(3):497-515  Please request from Markus Library.

Abzhanov, A; Kuo, WP; Hartmann, C; Grant, BR; Grant, PR; Tabin, CJ.  2006.  The Calmodulin pathway and evolution of elongated beak morphology of Darwin’s finches.  NATURE.  442(7102):563-567

Burns, KJ; Hackett, SJ; Klein, NK.  2002.  Phylogenetic relationships and morphological diversity in Darwin’s finches and their relatives.  Evolution  56(6):1240-1252

Arthur, W.  2006.   D’Arcy Thompson and the theory of transformationsNATURE  Reviews Genetics.  7(5):401-U3

Kirschn er, M; Gerhart, J.  1998.  Evolvability.  PNAS.  95(15): 8420-8427

Sato, A; Tichy, H; O’huigin, C; Grant, PR; Grant, BR; Klein, J.   2001.  On the origin of Darwin’s finchesMolecular Biology and Evolution.  18(3):299-311

Petren, K; Grant, PR; Grant, BR; Keller, LF.  2005.  Comparative landscape genetics and the adaptive radiation of Darwin’s finches: the role of peripheral isolation.   Molecular Ecology.  14(10):2943-2957

Stone, JR.  1997.  The spirit of D’Arcy Thompson dwells in empirical morphospace.  Mathematical Biosciences.  142(1):13-30    Please request from Markus Library


Recommended Readings: John T. Lis, Ph.D.

Friday Lecture Series

New Views of Local and Genome-wide Transcription Regulation In Vivo

John T. Lis, Ph.D.,

Barbara McClintock Professor of Molecular Biology and Genetics, Cornell University

October 15, 2010

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings:

Core, L. J., and J. T. Lis. 2008. Transcription regulation through promoter-proximal pausing of RNA polymerase II. Science 319, (5871): 1791-1792

Fuda, N. J., M. B. Ardehali, and J. T. Lis. 2009. Defining mechanisms that regulate RNA polymerase II transcription in vivo. Nature 461, (7261): 186-192

Hall, M. A., A. Shundrovsky, L. Bai, R. M. Fulbright, J. T. Lis, and M. D. Wang. 2009. High-resolution dynamic mapping of histone-DNA interactions in a nucleosome. Nature Structural and Molecular Biology 16, (2): 124-129

Lis, J. T. 2007. Imaging drosophila gene activation and polymerase pausing in vivo. Nature 450, (7167): 198-202

Saunders, A., L. J. Core, and J. T. Lis. 2006. Breaking barriers to transcription elongation. Nature Reviews Molecular Cell Biology 7, (8): 557-567

NIH Symposium in 100 Years of Sickle Cell Research

Registration is open for the James B. Herrick Symposium: 100 Years of Sickle Cell Research, on November 16-17, 2010, at the National Institutes of Health (NIH) in Bethesda, Maryland.

 The trans-NIH symposium will commemorate the 100th anniversary of Dr. James Herrick’s initial description of sickle cell anemia by convening leading sickle cell experts to celebrate research advances and explore promising new scientific opportunities.  The symposium also will provide an opportunity for the NIH to honor the contributions of the many individuals with sickle cell disease who have, through their participation in clinical studies, made progress possible.

 For more information, please visit the symposium website,,