Recommended Readings: Mario Halic, PhD Oct 11 2010

Monday Lecture Series

Dicer-independent Primal RNAs Trigger RNAi and Heterochromatin Formation

Mario Halic, Ph.D.,

Post Doctoral Fellow 

Department of  Cell Biology

Harvard Medical School

October 11, 2010

4:00 p.m.  Welch Hall Level Two


Recommended Readings:

Yang JS, Maurin T, Robine N, et al.  2010.   Conserved vertebrate mir-451 provides a platform for Dicer-independent, Ago2-mediated microRNA biogenesis.   PNAS   107(34):15163-15168   

Lee HC, Li LD, Gu WF, et al.  2010.  Diverse Pathways Generate MicroRNA-like RNAs and Dicer-Independent Small Interfering RNAs in Fungi.  MOLECULAR CELL   38 ( 6):803-814   

Cifuentes D, Xue HL, Taylor DW, et al.  2010.  A Novel miRNA Processing Pathway Independent of Dicer Requires Argonaute2 Catalytic Activity.   SCIENCE    328( 5986):1694-1698   

 Cheloufi S, Dos Santos CO, Chong MMW, et al.: 2010.  A Dicer-independent miRNA biogenesis pathway that requires Ago catalysis.   NATURE   465( 7298):584-

Halic M, Moazed D.  2010.   Dicer-Independent Primal RNAs Trigger RNAi and Heterochromatin Formation. CELL    140( 4):504-516  

Cao F, Li XZ, Hiew S, et al.  2009.  Dicer independent small RNAs associate with telomeric heterochromatin.  RNA-A PUBLICATION OF THE RNA SOCIETY    15(7):1274-1281.   Please request from Markus Library.

Kawamura Y, Saito K, Kin T, et al.  2008.  Drosophila endogenous small RNAs bind to Argonaute 2 in somatic cells.   NATURE   453(7196):793-U5

Klattenhoff C, Theurkauf W .  2008.  Biogenesis and germline functions of piRNAs.  DEVELOPMENT  135(1):3-

Recommended Readings: Tomasz Religa, PhD Oct 4 2010

Monday Lecture Series

The Gating Mechanism of an Archaeal Proteasome

Tomasz Religa, Ph.D.,

Post Doctoral Fellow 

Department of  Molecular Genetics

University of Toronto

October 4, 2010

4:00 p.m.  Welch Hall Level Two


Recommended Readings:

Baldwin AJ, Religa TL, Hansen DF, et al.  2010. (CHD2)-C-13 Methyl Group Probes of Millisecond Time Scale Exchange in Proteins by H-1 Relaxation Dispersion: An Application to Proteasome Gating Residue DynamicsJOURNAL OF THE AMERICAN CHEMICAL SOCIETY    132(32):10992-10995   

Religa TL, Kay LE.  2010. Optimal methyl labeling for studies of supra-molecular systems .   JOURNAL OF BIOMOLECULAR NMR    47(3):163-169   

Religa TL, Sprangers R, Kay LE.  2010. Dynamic Regulation of Archaeal Proteasome Gate Opening As Studied by TROSY NMR.   SCIENCE    328(5974):98-102   

Marques AJ, Palanimurugan R, Matias AC, et al.  2009.  Catalytic Mechanism and Assembly of the Proteasome.  CHEMICAL REVIEWS    109(4):1509-1536 

Humbard MA, Zhou G, Maupin-Furlow JA .  2009. The N-Terminal Penultimate Residue of 20S Proteasome alpha 1 Influences its N-alpha Acetylation and Protein Levels as Well as Growth Rate and Stress Responses of Haloferax volcanii.   JOURNAL OF BACTERIOLOGY    191(12): 3794-3803   

Bajorek M, Glickmann MH.  2004.  Ubiquitin-proteasome system – Keepers at the final gates: regulatory complexes and gating of the proteasome channel.   CELLULAR AND MOLECULAR LIFE SCIENCES  61(13): 1579-1588   

 Groll M, Brandstetter H, Bartunik H, et al.  2003.  Investigations on the maturation and regulation of archaebacterial proteasomes.   JOURNAL OF MOLECULAR BIOLOGY    327(1): 75-83