Recommended Readings: Daniel Kronauer Ph.D. March 8 2010

Monday Lecture Series

The Birth, Life and Death of an Army Ant Superorganism

Daniel Kronauer, Ph.D.,

Junior Fellow, Harvard Society of Fellows

Museum of Comparative Zoology, Harvard University

March 8, 2010

Welch Hall,  Level Two

4:00 p.m.-5:00 p.m

Recommended Readings:

Kronauer DJC, Schoning C, d’Ettorre P, et al.   2010.  Colony fusion and worker reproduction after queen loss in army ants. PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES 277(1682):755-763

Tarapore D, Floreano D, Keller L.   2010.   Task-dependent influence of genetic architecture and mating frequency on division of labour in social insect societies. BEHAVIORAL ECOLOGY AND SOCIOBIOLOGY 64(4):675-684

Kronauer DJC.   2009.   Recent advances in army ant biology (Hymenoptera: Formicidae) . MYRMECOLOGICAL NEWS 12:51-65

Powell S.    2009.   How ecology shapes caste evolution: linking resource use, morphology, performance and fitness in a superorganism. JOURNAL OF EVOLUTIONARY BIOLOGY   22(5):1004-1013

Berghoff SM, Kronauer DJC, Edwards KJ, et al.  2008. Dispersal and population structure of a New World predator, the army ant Eciton burchellii. JOURNAL OF EVOLUTIONARY BIOLOGY 21(4):1125-1132

Kronauer DJC, Berghoff SM, Powell S, et al.  2006.   A reassessment of the mating system characteristics of the army ant Eciton burchellii. NATURWISSENSCHAFTEN 93(8):402-406

Kronauer DJC, Johnson RA, Boomsma JJ.   2007.  The evolution of multiple mating in army ants. EVOLUTION 61(2):413-422

Kronauer DJC, Schoning C, Pedersen JS, et al.  2004.  Extreme queen-mating frequency and colony fission in African army ants.  MOLECULAR ECOLOGY 13(8):2381-2388      Request full article from Markus Library.

Recommended Readings: John B. Gurdon, D. Phil.

Friday Lecture Series

Richard M. Furlaud Distinguished Lecture

Nuclear Reprogramming by Eggs and the Reversal of Cell Differentiation

John B. Gurdon,  D. Phil

group leader, The Wellcome Trust/Cancer Research UK  Gurdon Institute

February 26, 2010

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Articles:

Gurdon, J. B. From nuclear transfer to nuclear reprogramming: The reversal of cell differentiation.2006

Gurdon, J. B., J. A. Byrne, and S. Simonsson. 2003. Nuclear reprogramming and stem cell creation. Proceedings of the National Academy of Sciences of the United States of America 100, (SUPPL. 1): 11819-11822

Gurdon, J. B., and D. A. Melton. 2008. Nuclear reprogramming in cells. Science 322, (5909): 1811-1815

Ng, R. K., and J. B. Gurdon. 2008. Epigenetic inheritance of cell differentiation status. Cell Cycle 7, (9): 1173-1177

Simonsson, S., and J. Gurdon. 2004. DNA demethylation is necessary for the epigenetic reprogramming of somatic cell nuclei. Nature cell biology 6, (10): 984-990

Recommended Readings: Carla J. Shatz, Ph.D.

Friday Lecture Series

Moonlighting MHCI: Releasing the Brake on Synaptic Plasticity

Carla J. Shatz,  Ph. D.,

professor of biology and neurobiology and director, Bio-X, Stanford University

February 19, 2010

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Articles:

Boulanger, L. M., and C. J. Shatz. 2004. Immune signalling in neural development, synaptic plasticity and disease. Nature Reviews Neuroscience 5, (7): 521-531

Butts, D. A., P. O. Kanold, and C. J. Shatz. 2007. A burst-based “hebbian” learning rule at retinogeniculate synapses links retinal waves to activity-dependent refinement. PLoS Biology 5, (3): 0651-0661

Goddard, C. A., D. A. Butts, and C. J. Shatz. 2007. Regulation of CNS synapses by neuronal MHC class I. Proceedings of the National Academy of Sciences of the United States of America 104, (16): 6828-6833

Kanold, P. O., and C. J. Shatz. 2006. Subplate neurons regulate maturation of cortical inhibition and outcome of ocular dominance plasticity. Neuron 51, (5): 627-638

Syken, J., T. GrandPre, P. O. Kanold, and C. J. Shatz. 2006. PirB restricts ocular-dominance plasticity in visual cortex. Science 313, (5794): 1795-1800

Tagawa, Y., P. O. Kanold, M. Majdan, and C. J. Shatz. 2005. Multiple periods of functional ocular dominance plasticity in mouse visual cortex. Nature neuroscience 8, (3): 380-388

Discovering the Origin of Adult Blood Stem Cells

ScienceDaily (Feb. 16, 2010) — Biologists at UC San Diego have identified the specific region in vertebrates where adult blood stem cells arise during embryonic development.     Their discovery, which appears in a paper in this week’s early online edition of the journal Nature, is a critical first step for the development of safer and more effective stem cell therapies for patients with leukemia, multiple myeloma, anemia and a host of other diseases of the blood or bone marrow.

Read the details in early online publication in NATURE.

Recommended Readings: Paul Bieniasz Ph.D. March 1 2010

Monday Lecture Series

Retrovirus Replication in Hostile Host Cells

Paul Bieniasz, Ph.D.

Associate Professor; Investigator, HHMI


Aaron Diamond AIDS Research Center:  Laboratory of Retrovirology

4:00p.m.-5:00 p.m.

Recommended Readings:

Fritz JV, Dujardin D, Godet J, et al.   2010. HIV-1 Vpr Oligomerization but Not That of Gag Directs the Interaction between Vpr and Gag. JOURNAL OF VIROLOGY 84(3): 1585-1596

Jouvenet, N; Simon, SM; Bieniasz, PD.  2009.  Imaging the interaction of HIV-1 genomes and Gag during assembly of individual viral particles. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 106(45): 19114-19119

Zhang, FW; Wilson, SJ; Landford, WC, et al.   2009.  Nef Proteins from Simian Immunodeficiency Viruses Are Tetherin Antagonists. CELL HOST & MICROBE 6(1): 54-67

Neil, Stuart; Bieniasz, Paul    2009.  Human Immunodeficiency Virus, Restriction Factors, and Interferon.  Journal of Interferon and Cytokine Research    29(9): 569-580 Request from Markus Library.

Bieniasz, PD.  2009.  The Cell Biology of HIV-1 Virion Genesis. CELL HOST & MICROBE   5(6): 550-558

Hatziioannou, T; Ambrose, Z; Chung, NPY, et al.   2009.   A macaque model of HIV-1 infection. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 106(11): 4425-4429

Recommended Readings: Philipp Niethammer Ph.D. Mon Feb 22, 2010

Monday Lecture Series

SpatioTemporal Control of Wound Detection

Philipp Niethammer, Ph.D.,

Post Doctoral Fellow, Department of Systems Biology

Harvard Medical School

February 22, 2010

Welch Hall,  Level Two

4:00 p.m.-5:00 p.m

Recommended Articles:

Niethammer, P; Grabher, C; Look, AT, et al.   2009.  A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish. NATURE 459(7249): 996-U123

Niethammer, P; Kueh, HY; Mitchison, TJ.  2008.  Spatial patterning of metabolism by mitochondria, oxygen, and energy sinks in a model cytoplasm. CURRENT BIOLOGY 18(8): 586-591

Yoo SK, Huttenlocher A.  2009.  Innate Immunity: Wounds Burst H2O2 Signals to Leukocytes. CURRENT BIOLOGY 19(14, Sp. Iss. SI): R553-R555

Allaoui A, Botteaux A, Dumont JE, et al.  2009.  Dual oxidases and hydrogen peroxide in a complex dialogue between host mucosae and bacteria.   TRENDS IN MOLECULAR MEDICINE 15(12): 571-579   Request from Markus Library.

Chamberlain, CS; Crowley, E; Vanderby, R.  2009.  The spatio-temporal dynamics of ligament healing. WOUND REPAIR AND REGENERATION 17(2): 206-215

Adams, Stephanie; Munz, Barbara .  2010.  RIP4 is a target of multiple signal transduction pathways in keratinocytes: Implications for epidermal differentiation and cutaneous wound repair. Experimental Cell Research 316(1):126-137

Eligini, S; Arenaz, I; Barbieri, SS, et al.  2009.  Cyclooxygenase-2 mediates hydrogen peroxide-induced wound repair in human endothelial cells. FREE RADICAL BIOLOGY AND MEDICINE 46(10): 1428-1436

Ushio-Fukai, M.  2006.  Redox signaling in angiogenesis: Role of NADPH oxidase. CARDIOVASCULAR RESEARCH 71(2):226-235

2009 “Hottest biology papers”

Of the five “hottest” papers of 2009 in biology, three were published in NATURE, two in CELL.  The topics are no surprise: genomics and stem cells.   Click and read:

1. K. Takahashi, et al.,Induction of pluripotent stem cells from adult human fibroblasts by defined factors,” Cell, 131: 861-72, 2007.
Citations this year: 520
Total citations to date: 886
Findings: This work from Shinya Yamanaka’s lab in Japan was the first to demonstrate that induced pluripotent stem (iPS) cells can be generated from adult human dermal fibroblasts. Previous efforts by the team showed that iPS cells could be derived from mouse somatic cells
2. K.A. Frazer, et al.,A second generation human haplotype map of over 3.1 million SNPs,” Nature, 449: 854-61, 2007.
Citations this year: 389
Total citations to date: 588
Findings: Since the sequencing of the human genome in 2003, the International HapMap Project has explored single nucleotide polymorphisms (SNPs) — differences in a single letter of the DNA — to study how these small variations affect the development of diseases and the body’s response to pathogens and drugs. HapMap I, the original report, placed one SNP at roughly every 5,000 DNA letters. The newest map, featured in this paper, sequenced an additional 2 million SNPs, increasing the map’s resolution to one SNP per kilobase. The additional detail allows scientists to more closely investigate patterns in SNP differences, especially in hotspot regions, or concentrated stretches of DNA.

3. A. Barski, et al.,High-resolution profiling of histone methylations in the human genome,” Cell, 129: 823-37, 2007.
Citations this year: 299
Total citations to date:: 560
Findings: This study looked at how histone modifications influence gene expression in more detail than previous attempts. Using a powerful sequencing tool called Solexa 1G, the researchers mapped more than 20 million DNA sequences associated with specific forms of histones, finding there were differences in methylation patterns between stem cells and differentiated T cells.

4. E. Birney, et al.,Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project, “Nature, 447: 799-816, 2007.
Citations this year: 267
Total citations to date: 618
Findings: The ENCODE project — ENCODE stands for the ENCyclopedia Of DNA Elements — set out to identify all functional elements in the human genome. After examining one percent of the genome, the paper revealed several new insights about how information encoded in the DNA comes to life in a cell.

5. A M. Wernig, et al.,In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state,” Nature 448: 318-24, 2007.
Citations this year: 237
Total citations to date: 512
Findings: Scientists successfully performed somatic-cell nuclear transfer (SCNT), producing stem cell lines and cloned animals for the first time using fertilized mouse eggs.

Recommended Readings: Mary-Claire King, Ph.D.

Friday Lecture Series

Joshua Lederberg Memorial Lecture

Anna Karenina as a Model for the Genetics of Complex Disease:

How Every Unhappy Family Is Unhappy in Its Own Way

Mary-Claire King, Ph.D.,

American Cancer Society Professor, departments of genome sciences and medicine, University of Washington, Seattle

February 5, 2010

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Articles:

Walsh, T., McClellan, J. M., McCarthy, S. E., Addington, A. M., Pierce, S. B., Cooper, G. M., et al. (2008). Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia. Science, 320(5875), 539-543

Sebat, J., Lakshmi, B., Malhotra, D., Troge, J., Lese-Martin, C., Walsh, T., et al. (2007). Strong association of de novo copy number mutations with autism. Science, 316(5823), 445-449

McClellan, J. M., Susser, E., & King, M. -. (2006). Maternal famine, de novo mutations, and schizophrenia. Journal of the American Medical Association, 296(5), 582-584

Feldman, M. W., Lewontin, R. C., & King, M.  (2003). A genetic melting-pot. Nature, 424(6947), 374

King, M. -., & Motulsky, A. G. (2002). Human genetics: Mapping human history. Science, 298(5602), 2342-2343