Recommended Readings: Leslie Vosshall Ph.D. Nov 30, 2009

Monday Lecture


Olfaction: From Perception to Receptors

Leslie Vosshall PhD

Chemers Family Associate Professor; Investigator HHMI
Laboratory of Neurogenetics and Behavior

The Rockefeller University

Nov. 30, 2009

Welch Hall, Level Two   4 p.m.

Recommended Articles:

 Su CY, Menuz K, Carlson JR.   2009.  Olfactory Perception: Receptors, Cells, and Circuits.  CELL  139(1): 45-59

  Wilson RI .  2008. Neural and behavioral mechanisms of olfactory perception. CURRENT OPINION IN NEUROBIOLOGY  18(4): 408-412

 Gottfried JA.  2008.  Perceptual and Neural Plasticity of Odor Quality Coding in the Human Brain.  CHEMOSENSORY PERCEPTION   1(2): 127-135    Request article from Markus Library.

Benton R, Sachse S, Michnick S, Vosshall L.  2006  Atypical membrane topology and heteromeric function of Drosophila odorant receptors in vivo.  PLoS Biology  4(2):240-257   

 Gottfried JA, Dolan RJ. 2003.  The nose smells what the eye sees: Crossmodal visual facilitation of human olfactory perceptionNEURON   39(2): 375-386

Ha TS, Smith DP.  2009.  Odorant and pheromone receptors in insects. Frontiers in Cellular Neuroscience.  3:10.

Menashe I, Abaffy T, Hasin Y, Goshen S, Yahalom V, Luetje CW, Lancet D.  2007.  Genetic elucidation of human hyperosmia to isovaleric acid. PLoS Biology  5(11):e284.

Yannis Michalakis & François Renaud.  2009.  Malaria: Evolution in vector control. Nature 462, 298-300

Immediate, Aggressive Spending on HIV/AIDS Could End Epidemic

ScienceDaily (Nov. 18, 2009) — Money available to treat HIV/AIDS is sufficient to end the epidemic globally, but only if we act immediately to control the spread of the disease. That was the conclusion of a study just published in the open-access journal, BMC Public Health. This approach defies conventional thinking, which recommends gradual spending over 15-20 years. Canadian Researchers found that an aggressive program over five years is the only way to end the epidemic given our current resources.  The study, part of a supplement on “The OptAIDS project: towards global halting of HIV/AIDS,” was based on a leading-edge mathematical model developed by mathematicians and biologists.   The research is in press; read more at ScienceDaily….

Recommended Readings: Jean-Laurent Casanova, M.D., Ph.D.

Friday Lecture Series:

M.D.-Ph.D. Recruitment Lecture

Two Kindreds with X-linked Recessive Mycobacterial Disease: Toward a Genetic Theory of Infectious Diseases

Jean-Laurent Casanova, M.D.,  Ph.D.

professor and head, Laboratory of Human Genetics of Infectious Diseases, Rockefeller University

November 20, 2009

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Articles:

Bustamante, J., S. Boisson-Dupuis, E. Jouanguy, C. Picard, A. Puel, L. Abel, and J. -L Casanova. 2008. Novel primary immunodeficiencies revealed by the investigation of paediatric infectious diseases. Current opinion in immunology 20, (1): 39-48

Casanova, J. -L, and L. Abel. 2007. Primary immunodeficiencies: A field in its infancy. Science 317, (5838): 617-619

Maródi, L., and J. -L Casanova. 2009. Primary immunodeficiency diseases: The J project. The Lancet 373, (9682): 2179-2181

Quintana-Murci, L., A. Alcaïs, L. Abel, and J. -L Casanova. 2007. Immunology in natura: Clinical, epidemiological and evolutionary genetics of infectious diseases. Nature immunology 8, (11): 1165-1171

Von Bernuth, H., C. Picard, Z. Jin, R. Pankla, H. Xiao, C. -L Ku, M. Chrabieh, et al. 2008. Pyogenic bacterial infections in humans with MyD88 deficiency. Science 321, (5889): 691-696

French Coffee Cake

1  cup sugar

1.5 cups flour

1 egg

1/2 cup olive oil

1 cup milk

1/2 tsp salt

2 tsp baking powder

1 tsp vanilla

Put all ingredients in medium bowl and beat on high for two minutes until smooth.  pour into ungreased 9×9 (or similar sized) pan.      Bake for 30 minutes at 350 degrees until the edges begin to brown.   While still hot from the oven, drizzle 1/2 cup melted butter over the top, and sprinkle liberally with mixture of cinnamon and sugar.   Tastiest while still warm.

Recommended Readings: Eddy De Robertis, Ph.D., Nov 13, 2009

Friday Lecture Series

From Spemann’s Organizer to the Integration of BMP and Wnt Signaling Gradients in Embryos

Eddy De Robertis, M.D.,  Ph.D.

Norman Sprague Professor of Biological Chemistry, University of California, Los Angeles; investigator, Howard Hughes Medical Institute

November 13, 2009

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Articles:

De Robertis, E. M. 2006. Spemann’s organizer and self-regulation in amphibian embryos. Nature Reviews Molecular Cell Biology 7, (4): 296-302

De Robertis, E. M., and Kuroda, H. 2004.  Dorsal-ventral patterning and neural induction in xenopus embryos. Annual Review of Cell and Developmental Biology, 20: 285-308

Fuentealba, L. C., E. Eivers, A. Ikeda, C. Hurtado, H. Kuroda, E. M. Pera, and E. M. De Robertis. 2007. Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal. Cell 131, (5): 980-993

Lee, H. X., A. L. Ambrosio, B. Reversade, and E. M. De Robertis. 2006. Embryonic dorsal-ventral signaling: Secreted frizzled-related proteins as inhibitors of tolloid proteinases. Cell, 124, (1): 147-159

Reversade, B., and E. M. De Robertis. 2005. Regulation of ADMP and BMP2/4/7 at opposite embryonic poles generates a self-regulating morphogenetic field. Cell 123, (6): 1147-1160

Recommended Readings: Vincent A. Fischetti PhD Nov 23, 2009

Monday Lecture


Using What Phage have Learned to Kill Gram-positive Bacteria

Vincent A. Fischetti PhD

Laboratory of Bacterial Pathogenesis and Immunology

Rockefeller University

Nov. 23, 2009

Welch Hall, Level Two

Recommended Readings: 

O’Flaherty S, Ross RP, Coffey A .  2009.  Bacteriophage and their lysins for elimination of infectious bacteria.   FEMS MICROBIOLOGY REVIEWS    33(4):801-819  

Frias MJ, Melo-Cristino J, Ramirez M. 2009. The Autolysin LytA Contributes to Efficient Bacteriophage Progeny Release in Streptococcus pneumoniae.  JOURNAL OF BACTERIOLOGY   191(17):5428-5440  

 Fischetti VA.  2008.   Bacteriophage lysins as effective antibacterials.  CURRENT OPINION IN MICROBIOLOGY  11(5):393-400    

Raz A, Fischetti VA.  2008.  Sortase A localizes to distinct foci on the Streptococcus pyogenes membrane.  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 105(47):18549-18554     

 Celia LK, Nelson D, Kerr DE.  2008.  Characterization of a bacteriophage lysin (Ply700) from Streptococcus uberis.  VETERINARY MICROBIOLOGY  130(1-2):107-117   Request this article from Markus Library

 Fischetti VA.  2007.  Harnessing the host response for antiinfective therapy.  INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS  29(Supple 2):S97-S97   Request this article from Markus Library.

 Rotem S, Radzishevsky I, Inouye RT, et al.  2006.  Identification of antimicrobial peptide regions derived from genomic sequences of phage lysins.  PEPTIDES  27(1):18-26   Request this article from Markus Library.

 Cheng Q, Nelson D, Zhu SW, Fischetti VA.  2005.  Removal of group B streptococci colonizing the vagina and oropharynx of mice with a bacteriophage, lytic enzyme.  ANTIMICROBIAL AGENTS AND CHEMOTHERAPY   49(1):111-117  

 Jado I, Lopez R, Garcia E, et al.  2003.  Phage lytic enzymes as therapy for antibiotic-resistant Streptococcus pneumoniae infection in a murine sepsis model. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY   52(6):967-973

Recommended Readings: Elizabeth S. Spelke, Ph.D., November 6, 2009

Friday Lecture Series

Developmental Origins of Abstract Concepts: Number and Geometry

Elizabeth S. Spelke, Ph. D.

Marshall L. Berkman Professor of Psychology, Harvard University

November 6, 2009

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Articles:

Hyde, D. C., & Spelke, E. S. (2009). All numbers are not equal: An electrophysiological investigation of small and large number representations.  Journal of Cognitive Neuroscience, 21(6), 1039-1053.

Barth, H., Beckmann, L., & Spelke, E. S. (2008). Nonsymbolic, approximate arithmetic in children: Abstract addition prior to instruction. Developmental Psychology, 44(5), 1466-1477.

Condry, K. F., & Spelke, E. S. (2008). The development of language and abstract concepts: The case of natural number. Journal of Experimental Psychology: General, 137(1), 22-38.

Kinzler, K. D., Dupoux, E., & Spelke, E. S. (2007). The native language of social cognition. Proceedings of the National Academy of Sciences of the United States of America, 104(30), 12577-12580.

Spelke, E. S., & Kinzler, K. D. (2007). Core knowledge. Developmental Science, 10(1), 89-96.

Barth, H., K. La Mont, J. Lipton, and E. S. Spelke. 2005. Abstract number and arithmetic in preschool children. Proceedings of the National Academy of Sciences of the United States of America 102, (39): 14116-14121