The New Biology of the 21st Century

The National Research Council’s Board on Life Sciences — which oversees studies on topics that include genomics, bioterrorism, stem cells, and other areas of interest in the life sciences — hosted a one-day symposium to mark its achievements of the past 25 years and look forward to future research. Their work identified that the integration of various disciplines into life sciences will, in the future, be the way to address some of our world’s most critical challenges:  energy, climate, food, health.  See the YouTube video on their conclusions.   Download your free copy of their report.

Recommended Readings: Charles D. Gilbert M.D., Ph.D. Nov 16, 2009

Monday Lecture Series

Dynamic Brain States

Charles  D. Gilbert, M.D., Ph.D.

Arthur and Janet Ross Professor,  Laboratory of Neurobiology

Monday, Nov 16, 2009

4:00 p.m.-5:00 p.m.

Second Floor, Welch Hall

Recommended Articles: 

Gilbert CD, Li W, Piech V.  2009.  Perceptual learning and adult cortical plasticityJournal of Physiology-London.    587(12): 2743-2751 

 De Meyer K, Spratling MW.   2009.  A model of non-linear interactions between cortical top-down and horizontal connections explains the attentional gating of collinear facilitation.  VISION.   49( 5): 553-568    Request article from Markus Library

Baker CI, Peli E, Knouf N, Kanwisher NG.  2005.  Reorganization of visual processing in macular degenerationJournal of Neuroscience.   25 : 614-618    

Bardy C, Huang JY, Wang C, et al.  2009.   “Top-down” influences of ipsilateral or contralateral postero-temporal visual cortices on the extra-classical receptive fields of neurons in cat’s striate cortex.   NEUROSCIENCE   158(2):951-966   

Setic M, Domijan D.  2008.  Modeling the top-down influences on the lateral interactions in the visual cortex.   BRAIN RESEARCH    1225( Sp. Iss. SI): 86-101   

Li W, Piech V, Gilbert CD.  2008.  Learning to link visual contoursNEURON.   57(3): 442-451  

 Seitz AR, Dinse HR.  2007.  A common framework for perceptual learning.  CURRENT OPINION IN NEUROBIOLOGY.  17(2):148-153   

 LI W.   2004.   Perceptual learning and top-down influences in primary visual cortex.  NATURE NEUROSCIENCE.   7:651

 CRIST RE.  2001.  Learning to see: experience and attention in primary visual cortex.  NATURE NEUROSCIENCE.      4: 519

Recommended Readings: Dinshaw J. Patel, Ph.D., Friday Oct. 30, 2009

Friday Lecture Series

Small RNAs: Mediators of Gene Regulation and RNA Silencing

Dinshaw J. Patel, Ph. D.

Abby Rockefeller Mauze Chair in Experimental Therapeutics, structural biology program, Memorial Sloan-Kettering Cancer Center;

professor, graduate program in biochemistry and structural biology, Weill School of Medical Sciences, Cornell University

October 30, 2009

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Articles:

Broyde, S., L. Wang, O. Rechkoblit, N. E. Geacintov, and D. J. Patel. 2008. Lesion processing: High-fidelity versus lesion-bypass DNA polymerases. Trends in biochemical sciences 33, (5): 209-219

Patel, D. J., J. B. Ma, Y. R. Yuan, K. Ye, Y. Pei, V. Kuryavyi, L. Malinina, G. Meister, and T. Tuschl. 2006. Structural biology of RNA silencing and its functional implications. Cold Spring Harbor symposia on quantitative biology 71, : 81-93

Patel, D. J., A. T. Phan, and V. Kuryavyi. 2007. Human telomere, oncogenic promoter and 5′-UTR G-quadruplexes: Diverse higher order DNA and RNA targets for cancer therapeutics. Nucleic acids research 35, (22): 7429-7455

Serganov, A., L. Huang, and D. J. Patel. 2008. Structural insights into amino acid binding and gene control by a lysine riboswitch. Nature 455, (7217): 1263-1267

Taverna, S. D., H. Li, A. J. Ruthenburg, C. D. Allis, and D. J. Patel. 2007. How chromatin-binding modules interpret histone modifications: Lessons from professional pocket pickers. Nature Structural and Molecular Biology 14, (11): 1025-1040

Zhang, X., Y. -R Yuan, Y. Pei, S. -S Lin, T. Tuschl, D. J. Patel, and N. -H Chua. 2006. Cucumber mosaic virus-encoded 2b suppressor inhibits arabidopsis Argonaute1 cleavage activity to counter plant defense. Genes and Development 20, (23): 3255-3268

Recommended Readings: Damon Page Ph.D. November 2, 2009

Monday Lecture


Influence of Pten and the Serotonin Pathway on Autism-like Endophenotypes in Mice


Damon Page Ph.D.

Postdoctoral Fellow

Picower Institute for Learning and Memory, Massachusetts Institute of Technology

Nov. 2, 2009

4:00 p.m. (Refreshments, 3:45 p.m.)

Welch Hall, Level Two

Recommended Readings: 

Page DT, Kuti OJ, Prestia C, et al.  2009.   Haploinsufficiency for Pten and Serotonin transporter cooperatively influences brain size and social behavior  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   106 (6): 1989-1994

 Bourgeron T.  2009.    A synaptic trek to autism.  CURRENT OPINION IN NEUROBIOLOGY    19( 2): 231-234

 Anderson BM, Schnetz-Boutaud NC, Bartlett J, et al.   2009.   Examination of association of genes in the serotonin system to autism.   NEUROGENETICS   10(3): 209-216     Request a copy of this paper from Markus Library.

 Skuse D.  2006.  Genetic influences on the neural basis of social cognition. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES    361(1476): 2129-2141 

 Cheh MA, Millonig JH, Roselli LM, et al.   2006. En2 knockout mice display neurobehavioral and neurochemical alterations relevant to autism spectrum disorder . BRAIN RESEARCH    1116:166-176   

 Olofsson, B; Page, DT.   2005.   Condensation of the central nervous system in embryonic Drosophila is inhibited by blocking hemocyte migration or neural activity
DEVELOPMENTAL BIOLOGY    279 (1 ) : 233-243

 Page, DT.  2002.  Inductive patterning of the embryonic brain in Drosophila . DEVELOPMENT    129 ( 9): 2121-2128   

Recommended Readings: Lily Jan Ph.D. Friday Oct. 23, 2009

Friday Lecture Series

Recent Studies of Potassium Channels and Calcium-activated Chloride Channels

Lily Jan, Ph.D.,

Jack and Delores Change Endowed Chair in Physiology and Biophysics

University of California San Francisco, Investigator, HHMI

October 23, 2009

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Articles:

Horresh I, Poliak S, Grant S, et al..  2008. Multiple Molecular Interactions Determine the Clustering of Caspr2 and Kv1 Channels in Myelinated Axons. JOURNAL OF NEUROSCIENCE 28(52): 14213-14222

Goldberg EM, Clark BD, Zagha E, et al..  2008. K+ channels at the axon initial segment dampen near-threshold excitability of neocortical fast-spiking GABAergic interneurons. NEURON 58 (3): 387-400

Kole MHP, Letzkus JJ, Stuart GJ.  2007. Axon initial segment Kv1 channels control axonal action potential waveform and synaptic efficacy. NEURON 55( 4): 633-647

Gu C, Zhou W, Puthenveedu MA, et al.  2006.  The microtubule plus-end tracking protein EB1 is required for Kv1 voltage-gated K+ channel axonal targeting. NEURON 52(5 ): 803-816

Kleopa KA, Elman LB, Lang B, et al.  2006.  Neuromyotonia and limbic encephalitis sera target mature Shaker-type K+ channels: subunit specificity correlates with clinical manifestations. BRAIN 129(Part 6):1570-1584

Hasband MN, Park EW, Zhen DK, et al.  2002.  Clustering of neuronal potassium channels is independent of their interaction with PSD-95. JOURNAL OF CELL BIOLOGY 159(4): 663-672

Poliak S, Gollan L, Martinez R, et al.  1999.  Caspr2, a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K+ channels.  NEURON 24(4): 1037-1047

Klumpp DJ, Song EJ, Ito S, et al.  1995.  The Shaker-like potassium channels of the mouse rod  bipolar cell and their contributions to the membrane current. JOURNAL OF NEUROSCIENCE 15 (7): 5004-5013 Part 1

Sheng M, Tsaur ML, Jan YN, et al.  1994.  Contrasting subcellular localization of the KV1.2 K+ channel subunit in different neurons of rat brain. JOURNAL OF NEUROSCIENCE 14( 4): 2408-2417

Recommended Readings: Stephen J. Elledge Ph.D. Friday Oct 16, 2009

Friday Lecture Series

DNA Damage Response: Stopped for Repairs

Stephen J Elledge, Ph.D., HHMI

Geneticist, Department of Medicine, Brigham and Women’s Hospital

Gregor Mendel Professor of Genetics, Harvard Medical School

October 16, 2009

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Review Article:

Kerzendorfer C, O’Driscoll M.  2009. Human DNA damage response and repair deficiency syndromes: Linking genomic instability and cell cycle checkpoint proficiency. DNA REPAIR 8(9):1139-1152

Recommended Articles:

Chaurushiya MS, Weitzman MD  2009. Viral manipulation of DNA repair and cell cycle checkpoints. DNA REPAIR 8 (9): 1166-1176

Zhang NX, Kaur R, Akhter S, et al.  2009.  Cdc5L interacts with ATR and is required for the S-phase cell-cycle checkpoint. EMBO REPORTS 10( 9):1029-1035

Yan J, Jetten, AM .  2008.   RAP80 and RNF8, key players in the recruitment of repair proteins to DNA damage sites. CANCER LETTERS 271 (2): 179-190

Fu Y, Pastushok L, Xiao W.  2008.  DNA damage-induced gene expression in Saccharomyces cerevisiae. FEMS MICROBIOLOGY REVIEWS 32 ( 6): 908-926

Wang H, Elledge, SJ.  2002.  Genetic and physical interactions between DPB11 and DDC1 in the yeast DNA damage response pathway. GENETICS 160( 4): 1295-1304

Tibbetts RS, Cortez D, Brumbaugh KM, et al. 2000.   Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress. GENES & DEVELOPMENT 14( 23): 2989-3002

Zhou, BBS; Elledge, SJ.   2000.  The DNA damage response: putting checkpoints in perspective
NATURE 408 (6811): 433-439

Recommended Readings: Michael Rosbash, Ph. D. Oct. 9, 2009

Friday Lecture Series

Circadian Rhythms and the Transcriptional Feedback Loop

Michael Rosbach, Ph. D., professor and director

National Center for Behavioral Genomics, Brandeis University;

Howard Hughes Medical Institute, investigator

October 9, 2009

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Articles:

Kadener, S., J. S. Menet, K. Sugino, M. D. Horwich, U. Weissbein, P. Nawathean, V. V. Vagin, P. D. Zamore, S. B. Nelson, and M. Rosbash. 2009. A role for microRNAs in the drosophila circadian clock. Genes and Development 23, (18): 2179-219

Kadener, S., D. Stoleru, M. McDonald, P. Nawathean, and M. Rosbash. 2007. Clockwork orange is a transcriptional repressor and a new drosophila circadian pacemaker component. Genes and Development 21, (13): 1675-168

Rosbash, M. 2009. The implications of multiple circadian clock origins. PLoS Biology 7, (3): 0421-0425

Shang, Y., L. C. Griffith, and M. Rosbash. 2008. Light-arousal and circadian photoreception circuits intersect at the large PDF cells of the drosophila brain. Proceedings of the National Academy of Sciences of the United States of America 105, (50): 19587-19594

Stoleru, D., P. Nawathean, M. d. l. P. Fernández, J. S. Menet, M. F. Ceriani, and M. Rosbash. 2007. The drosophila circadian network is a seasonal timer. Cell 129, (1): 207-219