Recommended Readings: Jerry Chipuk Ph.D. Oct 5, 2009

Monday Lecture Series

Mitochondrial Outer Membrane Permeabilization and Apoptosis are Regulated by Collaborative Interactions between the BCL-2 Family and Mitochondrial Physiology

Jerry Chipuk, Ph.D.

Postdoctoral Fellow, Deptartment of Immunology, St. Jude Children’s Research Hospital

Monday, October 5, 2009

4:00 p.m.-5:00 p.m.

(Refreshments, 3:45 p.m.-4:00 p.m.)

Second Floor, Welch Hall

Recommended Review Article:

Chipuk JE, Green DR.  2008.  How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?  TRENDS IN CELL BIOLOGY 18(4): 157-164

Recommended Articles:

Aslan JE, Thomas G.  2009.  Death by Committee: Organellar Trafficking and Communication in Apoptosis.  TRAFFIC 10(10): 1390-1404

Chipuk JE, Green DR.  2009.  PUMA cooperates with direct activator proteins to promote mitochondrial outer membrane permeabilization and apoptosis.  CELL CYCLE 8(17): 2692-2696

Chipuk JE, Bouchier-Hayes L, Green DR.  2006.  Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenario.  CELL DEATH AND DIFFERENTIATION 13(8): 1396-1402

Chipuk JE, Green DR.  2006.   Dissecting p53-dependent apoptosis.  CELL DEATH AND DIFFERENTIATION 13(6): 994-1002

Chipuk JE, Bouchier-Hayes L, Kuwana T, et al.  2005. PUMA couples the nuclear and cytoplasmic proapoptotic function of p53 .  SCIENCE 309(5741): 1732-1735

Kuwana T, Bouchier-Hayes L, Chipuk JE, et al.  2005.  BH3 domains of BH3-only proteins differentially regulate bax-mediated mitochondrial membrane permeabilization both directly and indirectly.  MOLECULAR CELL 17 (4): 525-535

Chipuk JE, Kuwana T, Bouchier-Hayes L, et al.  2004.   Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis.  SCIENCE 303(5660): 1010-1014

Recommended Readings: Songon An, Ph.D. Sept. 30, 2009

Wednesday Lecture

Chemical Biology of a Metabolic Multi-enzyme Complex in Cells:

the “Purinosome”

Songon An  Ph.D.

Postdoctoral Scholar

Pennsylvania State University, Department of Chemistry

Sept. 30, 2009

4:00 p.m. (Refreshments, 3:45 p.m.)

Welch Hall, Level Two

Recommended Articles:

An SG, Kumar R, Sheets ED, et al.  2008.  Reversible compartmentalization of de novo purine biosynthetic complexes in living cells. SCIENCE. 320 (5872): 103-106

DeLisa MP, Conrado RJ.  2009.  Synthetic metabolic pipelines.  NATURE BIOTECHNOLOGY. 27 (8): 728-729

Dueber JE , Wu GC, Malmirchegini GR, Moon TS, Petzold CJ, Ullal AV, Keasling JD.  2009.  Synthetic protein scaffolds provide modular control over metabolic flux. NATURE BIOTECHNOLOGY. 27 (8): 753-U107

Zhang Y, Morar M, Ealick SE.  2008.  Structural biology of the purine biosynthetic pathway. CELLULAR AND MOLECULAR LIFE SCIENCES 65 (23): 3699-3724    Request article from  Markus Library.

Conrado RJ, Varner JD, DeLisa MP.  2008.  Engineering the spatial organization of metabolic enzymes: mimicking nature’s synergy. CURRENT OPINION IN BIOTECHNOLOGY. 19 (5): 492-499

Recommended Readings: Paul W. Glimcher, Ph.D. Oct. 2, 2009

Friday Lecture Series

The Neurobiology of Decision-making

Paul W. Glimcher, Ph.D.,

Professor of  neural science, economics and psychology

New York University, Center of Neuroeconomics

October 2, 2009

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Articles:

Bayer, H. M., and P. W. Glimcher. 2005. Midbrain dopamine neurons encode a quantitative reward prediction error signal. Neuron 47,(1): 129-141

Dorris, M. C., and P. W. Glimcher. 2004. Activity in posterior parietal cortex is correlated with the relative subjective desirability of action. Neuron 44 (2): 365-378

Glimcher, P. W. 2008. Understanding risk: A guide for the perplexed. Cognitive,  Affective and Behavioral Neuroscience 8 (4): 348-354

Glimcher, P. W., and A. Rustichini. 2004. Neuroeconomics: The consilience of brain and decision. Science 306(5695): 447-452

Kable, J. W., and P. W. Glimcher. 2007. The neural correlates of subjective value during intertemporal choice. Nature neuroscience 10 (12): 1625-1633

Recommended Readings: Richard Leakey, Ph. D.; September 25, 2009

Friday Lecture Series

Fairfield Osborn Memorial Lecture

Richard E. Leakey, Professor

Stony Brook University; chairman, Wildlife Direct

September 25, 2009

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Articles:

Brown, B., A. Walker, C. V. Ward, and R. E. Leakey. 1993. New australopithecus boisei calvaria from east Lake Turkana, Kenya. American Journal of Physical Anthropology 91, (2): 137-159.

Brown, F., J. Harris, R. Leakey, and A. Walker. 1985. Early homo erectus skeleton from west Lake Turkana, Kenya. Nature 316, (6031): 788-792.

Harris, J. M., F. H. Brown, M. G. Leakey, A. C. Walker, and R. E. Leakey. 1988. Pliocene and pleistocene hominid-bearing sites from west of Lake Turkana, Kenya. Science 239, (4835): 27-33.

Leakey, R. E., and M. G. Leakey. 1986. A new miocene hominoid from Kenya. Nature 324, (6093): 143-146.

Walker, A., M. R. Zimmerman, and R. E. F. Leakey. 1982. A possible case of hypervitaminosis A in homo erectus. Nature 296, (5854): 248-250.

Recommended Books:

Leakey, Richard.   Wildlife wars: my battle to save Kenya’s elephants.   Pan Books.  2002

Leakey, Richard and Roger Lewin.  Origins: the emergence and evolution of our species and its possible future.  Penguin Books.  1991

Walker, Alan and Richard Leakey (eds).  The Nariokotome Homo erectus skeleton.  Springer. 1993

Leakey, Richard and Roger Lewin. The sixth extinction: patters of life and the future of humankind.  Anchor. 1996.

Leakey, Richard.  The origin of humankind.  Orion Publishing Group. 1994.

Leakey, Richard.  Origins reconsidered: in search of what makes us human.  Anchor.  1993.

NRC Calls for 10 Yr “New Biology” Initiative

NRC has proposed in a report -“A New Biology for the 21st Century: Ensuring the United States Leads the Coming Biology Revolution” –  spending at least 10 years and expanding federal biology funding to use the massive amounts of data generated from recent biological advances in an interdisciplinary and interagency initiative.  This initiative would integrate computer science, physics, engineering, chemistry, mathematics, and other sciences to address issues of global concern.  The intent  is to accelerate new breakthroughs that could solve some of society’s most pressing problems — particularly in the areas of food, environment, energy, and health science.

“A new biology initiative would be a daring addition to the nation’s research portfolio, but we believe the potential benefits are remarkable and far-reaching,” Phillip Sharp, who is institute professor for the Koch Institute for Integrative Cancer Research at the Massachusetts Institute of Technology and a co-chair on the committee that wrote the report, said in a statement.

“We need to set big goals, and let the problems drive the science,” added Thomas Connelly, Sharp’s fellow committee co-chair and an executive VP at E.I. DuPont de Nemours.

The committee of 16 biology, engineering, and computational scientists said that they developed these ‘new biology’ notions after asking a number of questions about how to use new advances in biology, particularly advances that generate massive amounts of data with “largely unanticipated payoffs,” such as the Human Genome Project.

Elaine Fuchs to be Awarded the National Medal of Science

President Barack Obama announced today that Elaine Fuchs,  a Howard Hughes Medical Institute investigator at The Rockefeller University, will receive the National Medal of Science for contributions to the biological sciences.  Dr. Fuchs is being honored for her work on mammalian skin and skin diseases.   She will be honored at the White House with eight other scientists on October 7.    Read more in the HHMI newsletter. 

Recommended Readings: Sean Curran, PhD. Monday, September 21, 2009

Monday Lecture Series

Paradoxes of Immortality: Surprising roles for Essential Genes in Regulating Lifespan

Sean Curran, Ph.D.

Postdoctoral Fellow, Deptartment of Molecular Biology, Massachusetts General

Department of Genetics, Harvard Medical School

Monday, September 21, 2009

4:00 p.m.-5:00 p.m.

(Refreshments, 3:45 p.m.-4:00 p.m.)

Second Floor, Welch Hall

Recommended Articles:

Karpac J, Jasper H.  2009.   Insulin and JNK: optimizing metabolic homeostasis and lifespan.    TRENDS IN ENDOCRINOLOGY AND METABOLISM 20( 3): 100-106 Request copy from Markus Library.

Vellai T.  2009. Autophagy genes and ageing. CELL DEATH AND DIFFERENTIATION 16(1): 94-102

Evans EA, Chen WC, Tan MW. 2008.  The DAF-2 insulin-like signaling pathway independently regulates aging and immunity in C-elegans.   AGING CELL 7(6): 879-893 Request copy from Markus Library.

Li J, Ebata A, Dong YQ, et al.  2008.  Caenorhabditis elegans HCF-1 functions in longevity maintenance as a DAF-16 regulator. PLOS BIOLOGY 6(9): 1870-1886

Salminen A, Ojala J, Huuskonen J. et al.   2008.    Interaction of aging-associated signaling cascades: Inhibition of NF-kappa B signaling by longevity factors FoxOs and SIRT1CELLULAR AND MOLECULAR LIFE SCIENCES 65 (7-8):1049-1058 Request copy from Markus Library

Greer EL, Brunet A   2008.  Signaling networks in aging. JOURNAL OF CELL SCIENCE 121(4):407-412

Curran SP, Ruvkun G.  2007. Lifespan regulation by evolutionarily conserved genes essential for viability.   PLOS GENETICS 3(4): e56

Pletcher SD, Kabil H, Partridge L. 2007.  Chemical complexity and the genetics of aging. ANNUAL REVIEW OF ECOLOGY EVOLUTION AND SYSTEMATICS 38: 299-326

Recommended Reading List: Caren Norden, PhD September 14, 2009

Monday Lecture Series

From Interkinetic Nuclear Migration to Lamination: Tissue Architecture in the Retina

Caren Norden, Ph.D.

Postdoctoral Fellow, Deptartment of Physiology, Development & Neuroscience

University of Cambridge

Monday, September 14, 2009

4:00 p.m.-5:00 p.m.

(Refreshments, 3:45 p.m.-4:00 p.m.)

Second Floor, Welch Hall

Recommended Articles:

Mendoza M, Norden C, Durrer K, et al.  2009.  A mechanism for chromosome segregation sensing by the NoCut checkpoint.   NATURE CELL BIOLOGY   11(4): 477-U273   

 Del Bene F, Wehman AM, Link BA, et al..  2008.  Regulation of neurogenesis by interkinetic nuclear migration through an apical-basal Notch gradient.  CELL   134(6): 1055-1065   

 Baye LM, Link BA .  2008.  Nuclear migration during retinal development.  BRAIN RESEARCH  1192: 29-36

Xie ZG, Moy LY, Sanada K, et al.  2007. Cep120 and TACCs control interkinetic nuclear migration and the neural progenitor pool.   NEURON    56(11):79-93   

 Baye LM, Link B.  2007.   Interkinetic nuclear migration and the selection of neurogenic cell divisions during vertebrate retinogenesis.   JOURNAL OF NEUROSCIENCE    27(38): 10143-10152   

 Norden C, Mendoza M, Dobbelaere J, et al. 2006.  The NoCut pathway links completion of cytokinesis to spindle midzone function to prevent chromosome breakage.  CELL  125(1): 85-98   

 Saito K, Kawaguchi A, Kashiwagi S, et al.  2003.  Morphological asymmetry in dividing retinal progenitor cells.   DEVELOPMENT GROWTH & DIFFERENTIATION   45(3): 219-229   

Linden R, Rehen SK, Chiarini LB.  1999.   Apoptosis in developing retinal tissue.  PROGRESS IN RETINAL AND EYE RESEARCH    18 (2): 133-165

Recommended Readings: Arun Mehra, Ph.D.; September 9, 2009

Monday Lecture Series

Temperature Compensation in Fungal and Bacterial Oscillators

Arun Mehra, Ph.D.

Postdoctoral Fellow, Department of Genetics,

Dartmouth Medical School

Wednesday, September 9, 2009

4:00 p.m.-5:00 p.m.

(Refreshments, 3:45 p.m.-4:00 p.m.)

Second Floor, Welch Hall

Recommended Articles:

Dunlap, J. C., J. J. Loros, H. V. Colot, A. Mehra, W. J. Belden, M. Shi, C. I. Hong, et al. 2007. A circadian clock in Neurospora: How genes and proteins cooperate to produce a sustained, entrainable, and compensated biological oscillator with a period of about a day. Cold Spring Harbor symposia on quantitative biology. 72:57-68.

Gooch, V. D., A. Mehra, L. F. Larrondo, J. Fox, M. Touroutoutoudis, J. J. Loros, and J. C. Dunlap. 2008. Fully codon-optimized luciferase uncovers novel temperature characteristics of the Neurospora clock. Eukaryotic Cell. 7(1):28-37.

Loros, J. J., J. C. Dunlap, L. F. Larrondo, M. Shi, W. J. Belden, V. D. Gooch, C. H. Chen, et al. 2007. Circadian output, input, and intracellular oscillators: Insights into the circadian systems of single cells. Cold Spring Harbor symposia on quantitative biology. 72:201-214. Contact Markus Library by sending article request to or fax request to ext. 7840.

Mehra, A., C. I. Hong, M. Shi, J. J. Loros, J. C. Dunlap, and P. Ruoff. 2006. Circadian rhythmicity by autocatalysis. PLoS Computational Biology. 2(7):0816-0823.

Mehra, A., Hong, C.I., Shi, M., Loros, J.J., Dunlap, J.C., Ruoff, P. 2006. Circadian rhythmicity by autocatalysis. PLoS computational biology. 2(7).

Mehra, A., M. Shi, C. L. Baker, H. V. Colot, J. J. Loros, and J. C. Dunlap. 2009. A role for casein kinase 2 in the mechanism underlying circadian temperature compensation. Cell. 137(4):749-760.