The HMS Beagle Project : Rebuilding the Beagle

Reawakening the origins of research

  by Emily Slutsky


Source: The Beagle Project

Pembrokeshire, UK, Mar. 4—Building a boat to celebrate a scientist’s career may not seem particularly commemorative. But when his pop-culture status is as pronounced as Benjamin Franklin’s or Albert Einstein’s, and his sea voyage is perhaps only rivaled by Christopher Columbus’ trifecta, a new boat for Charles Darwin is a fitting tribute.

2009 marks the bicentennial anniversary of Darwin’s birth, as well as the 150th anniversary of his landmark publication, On the Origin of Species. To celebrate his 1831 voyage aboard the famed ship, the aptly-named HMS Beagle Project—an ongoing initiative to revolutionize Darwin’s historical impact—is setting modern-day science to the backdrop of a sailing replica of the HMS Beagle.
The project is a £5-million effort (in 1820, the HMS Beagle was purchased for less than £8000) to construct a functional replica of the larch and oak HMS Beagle, equipped with modern-day improvisations such as diesel auxiliary engines, GPS navigation, satellite communications, and a 21st–century laboratory.

Recommended Readings: Shai Shaham, Ph.D.

Friday Lecture Series

“Adventures at the Sensory Synapse”

 Shai Shaham, Ph.D.

Associate Professor and Head, Laboratory of Developmental Genetics

The Rockefeller University

March 13, 2009

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Articles:

Bacaj, T., M. Tevlin, Y. Lu, and S. Shaham. 2008. Glia are essential for sensory organ function in C. elegans. Science. 322(5902):744-747.

 

Heiman, M. G., and S. Shaham. 2007. Ancestral roles of glia suggested by the nervous system of Caenorhabditis elegans. Neuron Glia Biology. 3(1):55-61. (Request copy of article from the Markus Library)

 

Shaham, S. 2006. Glia-neuron interactions in the nervous system of Caenorhabditis elegans. Current Opinion in Neurobiology. 16(5): 522-528.

 

Shaham, S. 2005. Glia-neuron interactions in nervous system function and development. Current Topics in Developmental Biology. 69:39-66.

 

Wang, Y., A. Apicella Jr., S. -K Lee, M. Ezcurra, R. D. Slone, M. Goldmit, W. R. Schafer, S. Shaham, M. Driscoll, and L. Bianchi. 2008. A glial DEG/ENaC channel functions with neuronal channel DEG-1 to mediate specific sensory functions in C. elegans. EMBO Journal. 27(18):2388-2399.

 

Wang, Y., A. Apicella Jr., S. -K Lee, M. Ezcurra, R. D. Slone, M. Goldmit, W. R. Schafer, S. Shaham, M. Driscoll, and L. Bianchi. 2008. A glial DEG/ENaC channel functions with neuronal channel DEG-1 to mediate specific sensory functions in C. elegans (EMBO journal (2008) 27, (2388-2399) DOI: 10.1038/emboj.2008.161). EMBO Journal. 27(19):2638.

 

Yoshimura, S., J. I. Murray, Y. Lu, R. H. Waterston, and S. Shaham. 2008. Mls-2 and vab-3 control glia development, h/h-17/Olig expression and glia-dependent neurite extension in C. elegans. Development. 135(13):2263-2275.

Recommended Readings: Tom W. Muir, Ph.D.

Friday Lecture Series

A Synthetic “Kiss of Death”

 Tom W. Muir, Ph.D.

Richard E. Salomon Professor and head, Selma and Lawrence Ruben Laboratory of Synthetic Protein Chemistry

The Rockefeller University

March 6, 2009

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Articles:

Alexeev, D., P. N. Barlow, S. M. Bury, J. -D Charrier, A. Cooper, D. Hadfield, C. Jamieson, et al. 2003. Synthesis, structural and biological studies of ubiquitin mutants containing (2S, 4S)-5-fluoroleucine residues strategically placed in the hydrophobic core. ChemBioChem. 4(9):894-896.

 

Alexeev, D., S. M. Bury, M. A. Turner, O. M. Ogunjobi, T. W. Muir, R. Ramage, and L. Sawyer. 1994. Synthetic, structural and biological studies of the ubiquitin system: Chemically synthesized and native ubiquitin fold into identical three-dimensional structures. Biochemical Journal. 299(1):159-163.

 

Chatterjee, C., R. K. McGinty, J. -P Pellois, and T. W. Muir. 2007. Auxiliary-mediated site-specific peptide ubiquitylation. Angewandte Chemie – International Edition. 46(16):2814-2818.

 

Chiang, K. P., and T. W. Muir. 2008. Systems- and molecular-level elucidation of signaling processes through chemistry. Science signaling. 1(42):pp. pe45.

 

Layfield, R., K. Franklin, M. Landon, G. Walker, P. Wang, R. Ramage, A. Brown, et al. 1999. Chemically synthesized ubiquitin extension proteins detect distinct catalytic capacities of deubiquitinating enzymes. Analytical Biochemistry. 274(1):40-49.

 

Love, S. G., T. W. Muir, R. Ramage, K. T. Shaw, D. Alexeev, L. Sawyer, S. M. Kelly, et al. 1997. Synthetic, structural and biological studies of the ubiquitin system: Synthesis and crystal structure of an analogue containing unnatural amino acids. Biochemical Journal. 323(3):727-734.

 

McGinty, R. K., J. Kim, C. Chatterjee, R. G. Roeder, and T. W. Muir. 2008. Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation. Nature. 453(7196):812-816.

 

Ramage, R., J. Green, T. W. Muir, O. M. Ogunjobi, S. Love, and K. Shaw. 1994. Synthetic, structural and biological studies of the ubiquitin system: The total chemical synthesis of ubiquitin. Biochemical Journal. 299(1):151-158.