Recommended Readings: Mark Schnitzer, Ph.D.

Special Seminar Series: Neurobiology and Behavior

Of mice, men, and microscopes: watching the brain dynamics of motor control at the cellular scale in behaving subjects

Mark Schnitzer, Ph.D.

Assistant Professor, Departments of Biological Sciences and Applied Physics

Stanford School of Medicine

Investigator, HHMI

4:00 p.m.-5:00 p.m. (Refreshments, 3:45 p.m.)

Second Floor, Welch Hall

Recommended Articles:

Deisseroth, K., G. Feng, A. K. Majewska, G. Miesenböck, A. Ting, and M. J. Schnitzer. 2006. Next-generation optical technologies for illuminating genetically targeted brain circuits. Journal of Neuroscience. 26(41):10380-10386.

Flusberg, B. A., E. D. Cocker, W. Piyawattanametha, J. C. Jung, E. L. M. Cheung, and M. J. Schnitzer. 2005. Fiber-optic fluorescence imaging. Nature Methods. 2(12):941-950.

Flusberg, B. A., J. C. Jung, E. D. Cocker, E. P. Anderson, and M. J. Schnitzer. 2005. In vivo brain imaging using a portable 3.9 gram two-photon fluorescence microendoscope. Optics Letters. 30(17):2272-2274.
Contact Markus Library to order a copy of this article.

Flusberg, B. A., A. Nimmerjahn, E. D. Cocker, E. A. Mukamel, R. P. J. Barretto, T. H. Ko, L. D. Burns, J. C. Jung, and M. J. Schnitzer. 2008. High-speed, miniaturized fluorescence microscopy in freely moving mice. Nature Methods5: 935 – 938 .

Jung, J. C., A. D. Mehta, E. Aksay, R. Stepnoski, and M. J. Schnitzer. 2004. In vivo mammalian brain imaging using one- and two-photon fluorescence microendoscopy. Journal of Neurophysiology. 92(5):3121-3133.

Llewellyn, M. E., R. P. J. Barretto, S. L. Delp, and M. J. Schnitzer. 2008. Minimally invasive high-speed imaging of sarcomere contractile dynamics in mice and humans. Nature. 454(7205):784-788.

Mehta, A. D., J. C. Jung, B. A. Flusberg, and M. J. Schnitzer. 2004. Fiber optic in vivo imaging in the mammalian nervous system. Current Opinion in Neurobiology. 14(5):617-628.

Miyawaki, A., and M. J. Schnitzer. 2007. New technologies for neuroscience. Current Opinion in Neurobiology. 17(5):565-566.

New Evidence for Influence of Epigenetics

 Scientists at the Centre for Addiction and Mental Health (CAMH) have found evidence that a secondary molecular mechanism called epigenetics may also account for some inherited traits and diseases.  Epigenetic factors may help explain currently unclear issues in human disease, such as the presence of a disease in only one monozygotic twin, the different susceptibility of males (e.g. to autism) and females (e.g. to lupus), significant fluctuations in the course of a disease (e.g. bipolar disorder, inflammatory bowel disease, multiple sclerosis), among numerous others.   These factors represent a new way to look for the molecular cause of disease, and eventually may lead to improved diagnostics and treatment.   See the research reported in Nature Genetics advance online publication January 2009.