Recommended Readings: Robert Froemke, Ph.D.

Monday Lecture Series

A Synaptic Memory Trace for Cortical Receptive Field Plasticity

Robert Froemke, Ph.D.

Post-doctoral Research Fellow, Department of Otolaryngology

University of California, San Francisco

Monday, January 26, 2009

4:00 p.m.-5:00 p.m. (Refreshments, 3:45 p.m.)

Second Floor, Welch Hall

Recommended Articles:

Froemke, R. C., and Y. Dan. 2002. Spike-timing-dependent synaptic modification induced by natural spike trains. Nature. 416(6879):433-438.

Froemke, R. C., M. M. Merzenich, and C. E. Schreiner. 2007. A synaptic memory trace for cortical receptive field plasticity. Nature. 450(7168):425-429.

Froemke, R. C., M. -M Poo, and Y. Dan. 2005. Spike-timing-dependent synaptic plasticity depends on dendritic location. Nature. 434(7030):221-225.

Froemke, R. C., I. A. Tsay, M. Raad, J. D. Long, and Y. Dan. 2006. Contribution of individual spikes in burst-induced long-term synaptic modification. Journal of Neurophysiology. 95(3):1620-1629.

Kenet, T., R. C. Froemke, C. E. Schreiner, I. N. Pessah, and M. M. Merzenich. 2007. Perinatal exposure to a noncoplanar polychlorinated biphenyl alters tonotopy, receptive fields, and plasticity in rat primary auditory cortex. Proceedings of the National Academy of Sciences of the United States of America. 104(18):7646-7651.

Urakubo, H., M. Honda, R. C. Froemke, and S. Kuroda. 2008. Requirement of an allosteric kinetics of NMDA receptors for spike timing-dependent plasticity. Journal of Neuroscience. 28(13):3310-3323.

Recommended Readings: Patrick Seale, Ph.D.

Monday Lecture Series (note: held on Tuesday 2.17.09)

The Transcriptional Regulator PRDM16 Controls a Brown Fat/Skeletal Muscle Development Switch

Patrick Seale, Ph.D.

Post-doctoral Research Fellow, Department of Cancer Biology

Dana-Farber Cancer Institute and Harvard Medical School

Tuesday, February 17, 2009

4:00 p.m.-5:00 p.m. (Refreshments, 3:45 p.m.)

Second Floor, Welch Hall

Recommended Articles:

Cannon, B., and J. Nedergaard. 2008. Developmental biology: Neither fat nor flesh. Nature. 454(7207):947-948.

Cooper, M. P., M. Uldry, S. Kajimura, Z. Arany, and B. M. Spiegelman. 2008. Modulation of PGC-1 coactivator pathways in brown fat differentiation through LRP130. Journal of Biological Chemistry. 283(46):31960-31967.

Kajimura, S., P. Seale, T. Tomaru, H. Erdjument-Bromage, M. P. Cooper, J. L. Ruas, S. Chin, P. Tempst, M. A. Lazar, and B. M. Spiegelman. 2008. Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex. Genes and Development. 22(10):1397-1409.

Lazar, M. A. 2008. Developmental biology: How now, brown fat? Science. 321(5892):1048-1049.

Seale, P., B. Bjork, W. Yang, S. Kajimura, S. Chin, S. Kuang, A. Scimè, et al. 2008. PRDM16 controls a brown fat/skeletal muscle switch. Nature. 454(7207):961-967.

Seale, P., S. Kajimura, W. Yang, S. Chin, L. M. Rohas, M. Uldry, G. Tavernier, D. Langin, and B. M. Spiegelman. 2007. Transcriptional control of brown fat determination by PRDM16. Cell Metabolism. 6(1):38-54.

 Uldry, M., W. Yang, J. St-Pierre, J. Lin, P. Seale, and B. M. Spiegelman. 2006. Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation. Cell Metabolism. 4(1):97.

Recommended Readings: David M. Smith, Ph.D.

Monday Lecture Series

The Proteasomal ATPases: Regulating a Protein Degradation Machine

David M. Smith, Ph.D.

Instructor, Department of Cell Biology

Harvard Medical School

Monday, February 9, 2009

4:00 p.m.-5:00 p.m. (Refreshments, 3:45 p.m.)

Second Floor, Welch Hall

Recommended Articles:

Smith, D. M., N. Benaroudj, and A. Goldberg. 2006. Proteasomes and their associated ATPases: A destructive combination. Journal of Structural Biology. 156(1):72-83.

Dou, Q. P., D. M. Smith, K. G. Daniel, and A. Kazi. 2003. Interruption of tumor cell cycle progression through proteasome inhibition: Implications for cancer therapy. Progress in cell cycle research. 5:441-446.
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Horwitz, A. A., A. Navon, M. Groll, D. M. Smith, C. Reis, and A. L. Goldberg. 2007. ATP-induced structural transitions in PAN, the proteasome-regulatory ATPase complex in archaea. Journal of Biological Chemistry. 282(31):22921-22929.

Nam, S., D. M. Smith, and Q. P. Dou. 2001. Ester bond-containing tea polyphenols potently inhibit proteasome activity in vitro and in vivo. Journal of Biological Chemistry. 276(16):13322-13330.

Rabl, J., D. M. Smith, Y. Yu, S. -C Chang, A. L. Goldberg, and Y. Cheng. 2008. Mechanism of gate opening in the 20S proteasome by the proteasomal ATPases. Molecular Cell. 30(3):360-368.

Smith, D. M., S. -C Chang, S. Park, D. Finley, Y. Cheng, and A. L. Goldberg. 2007. Docking of the proteasomal ATPases’ carboxyl termini in the 20S proteasome’s α ring opens the gate for substrate entry. Molecular Cell. 27(5):731-744.

 Smith, D. M., K. G. Daniel, Z. Wang, W. C. Guida, T. -H Chan, and Q. P. Dou. 2004. Docking studies and model development of tea polyphenol proteasome inhibitors: Applications to rational drug design. Proteins: Structure, Function and Genetics. 54(1):58-70.

Smith, D. M., G. Kafri, Y. Cheng, D. Ng, T. Walz, and A. L. Goldberg. 2005. ATP binding to PAN or the 26S ATPases causes association with the 20S proteasome, gate opening, and translocation of unfolded proteins. Molecular Cell. 20(5):687-698.

Recommended Readings: Marc W. Kirschner, Ph.D.

Special Seminar Series: Systems Biology

Systems Questions in Cell Biology: Cell Growth and Protein Level Homeostasis

Marc W. Kirschner, Ph.D.

Professor and Chair, Department of Systems Biology

Harvard Medical School

Wednesday, February 4, 2009

4:00 p.m.-5:00 p.m. (Refreshments, 3:45 p.m.)

Second Floor, Welch Hall

Recommended Articles:

Kirschner, M. W. 2005. The meaning of systems biology. Cell. 121(4):503-504.

Odde, D. J., L. Ma, A. H. Briggs, A. DeMarco, and M. W. Kirschner. 1999. Microtubule bending and breaking in living fibroblast cells. Journal of Cell Science. 112(19):3283-3288.

Drubin, D., S. Kobayashi, D. Kellogg, and M. Kirschner. 1988. Regulation of microtubule protein levels during cellular morphogenesis in nerve growth factor-treated PC12 cells. Journal of Cell Biology. 106(5):1583-1591.

Fang, G., Y. Hongtao, and M. W. Kirschner. 1998. Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1. Molecular Cell. 2(2):163-171.

Kothakota, S., T. Azuma, C. Reinhard, A. Klippel, J. Tang, K. Chu, T. J. McGarry, et al. 1997. Caspase-3-generated fragment of gelsolin: Effector of morphological change in apoptosis. Science. 278(5336):294-298.

Wolin, S. L., G. Krohne, and M. W. Kirschner. 1987. A new lamin in xenopus somatic tissues displays strong homology to human lamin A. EMBO Journal. 6(12):3809-3818.

Yew, P. R., and M. W. Kirschner. 1997. Proteolysis and DNA replication: The CDC34 requirement in the xenopus egg cell cycle. Science. 277(5332):1672-1676.