Recommended Readings: Rudolf Jaenisch, M.D.

Friday Lecture Series

Stem Cells, Pluripotency and Nuclear Reprogramming

 Rudolf Jaenisch, M.D.

Member, Whitehead Institute for Biomedical Research

Professor of Biology, Massachusetts Institute of Technology

Friday, January 30, 2009

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Articles:

Brambrink, T., R. Foreman, G. G. Welstead, C. J. Lengner, M. Wernig, H. Suh, and R. Jaenisch. 2008. Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells. Cell Stem Cell. 2(2):151-159.

Hanna, J., S. Markoulaki, P. Schorderet, B. W. Carey, C. Beard, M. Wernig, MennoP Creyghton, et al. 2008. Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency. Cell. 133(2):250-264.

Hochedlinger, K., and R. Jaenisch. 2006. Nuclear reprogramming and pluripotency. Nature. 441(7097):1061-1067.

Hockemeyer, D., F. Soldner, E. G. Cook, Q. Gao, M. Mitalipova, and R. Jaenisch. 2008. A drug-inducible system for direct reprogramming of human somatic cells to pluripotency. Cell Stem Cell. 3(3):346-353.

Jaenisch, R., and R. Young. 2008. Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming. Cell. 132(4):567-582.

Lewitzky, M., and S. Yamanaka. 2007. Reprogramming somatic cells towards pluripotency by defined factors. Current Opinion in Biotechnology. 18(5):467-473.

Mikkelsen, T. S., J. Hanna, X. Zhang, M. Ku, M. Wernig, P. Schorderet, B. E. Bernstein, R. Jaenisch, E. S. Lander, and A. Meissner. 2008. Dissecting direct reprogramming through integrative genomic analysis. Nature. 454(7200):49-55.

Wernig, M., C. J. Lengner, J. Hanna, M. A. Lodato, E. Steine, R. Foreman, J. Staerk, S. Markoulaki, and R. Jaenisch. 2008. A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types. Nature Biotechnology. 26(8):916-924.

Wernig, M., J. -P Zhao, J. Pruszak, E. Hedlund, D. Fu, F. Soldner, V. Broccoli, M. Constantine-Paton, O. Isacson, and R. Jaenisch. 2008. Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with parkinson’s disease. Proceedings of the National Academy of Sciences of the United States of America. 105(15):5856-5861.

Yamanaka, S. 2008. Pluripotency and nuclear reprogramming. Philosophical Transactions of the Royal Society B: Biological Sciences. 363(1500):2079-2087.

Recommended Readings: Uri Alon, Ph.D.

Special Seminar Series

Design Principles of Biological Circuits/on Science and Nurturing

Uri Alon, Ph.D.

Principal Investigator, Depts. of Molecular Cell Biology and Physics of Complex Systems

Weizmann Institute of Science

Wednesday, January 28, 2009

4:00 p.m.-5:00 p.m. (Refreshments, 3:45 p.m.)

Second Floor, Welch Hall

Recommended Book and Journal Articles:

Alon, Uri.  An Introduction to Systems Biology: Design Principles of Biological Circuits.  Boca Raton, FL: Chapman & Hall/CRC, 2007.  (2 copies of this book are available at the Markus Library Circulation Desk.

Geva-Zatorsky, N., N. Rosenfeld, S. Itzkovitz, R. Milo, A. Sigal, E. Dekel, T. Yarnitzky, et al. 2006. Oscillations and variability in the p53 system. Molecular systems biology [electronic resource]. 2.
Request PDF from Markus Library

Kalir, S., S. Mangan, and U. Alon. 2005. A coherent feed-forward loop with a SUM input function prolongs flagella expression in Escherichia coli. Molecular systems biology [electronic resource]. 1.
Request PDF from Markus Library

Kalisky, T., E. Dekel, and U. Alon. 2007. Cost-benefit theory and optimal design of gene regulation functions. Physical Biology. 4(4):229-245.

Kaplan, S., A. Bren, E. Dekel, and U. Alon. 2008. The incoherent feed-forward loop can generate non-monotonic input functions for genes. Molecular Systems Biology. 4.

Mangan, S., and U. Alon. 2003. Structure and function of the feed-forward loop network motif. Proceedings of the National Academy of Sciences of the United States of America. 100(21):11980-11985.

Mangan, S., S. Itzkovitz, A. Zaslaver, and U. Alon. 2006. The incoherent feed-forward loop accelerates the response-time of the gal system of Escherichia coli. Journal of Molecular Biology. 356(5):1073-1081.

Rosenfeld, N., J. W. Young, U. Alon, P. S. Swain, and M. B. Elowitz. 2007. Accurate prediction of gene feedback circuit behavior from component properties. Molecular Systems Biology. 3. article #3.

Rosenfeld, N., Young, J.W., Alon, U., Swain, P.S., and Elowitz, M.B. 2005. Gene regulation at the single-cell level. Science. 307(5717):1962-1965.

Novel Odor Detecting Proteins: Vosshall Lab Research Highlighted in CELL

A new class of olfactory proteins, labelled ‘ionotropic’ olfactory receptors may be key in finding ways to better control agricultural pests and to prevent insect borne disease.    The existence of ionotropic receptors has been known, but their role in communicating information from the environment to the brain had not been explored.    Read the details in today’s issue of Cell.

A Potential World of Tumor Suppressor Genes

Why do two of three humans never get cancer?  Are there cancer-resistant genotypes?  Perhaps evolution has favored a limited number of relatively common resistance genes that may nip incipient cancerous foci in the bud, i.e., to stop them at their inception.   George Klein of the Karolinska Insitute discusses this topic in the January  20, 2009 issue of PNAS.