A new report released by the Wildlife Conservation Society names 12 deadly pathogens likely to spread into new geographic regions of the endangering both human and animal populations. The “deadly dozen” includes ebola, avian flu, cholera, yellow fever, tuberculosis and other diseases that could easily spread with changing temperature and precipitation patterns, causing challenges to health, health care systems, national economies, and ecosystems. Read more at the Society website.
October 7, 2008
The American Physical Society congratulates Prof. Y. Nambu, Prof.
M. Kobayashi and Prof. T. Maskawa on winning the 2008 Nobel Prize in Physics. We are pleased to announce that three of Professor Nambu’s articles describing work honored by his Nobel Prize have been made “Free-to-Read” so they can be downloaded without a subscription. Links to the articles follow:
http://prola.aps.org/abstract/PR/v124/i1/p246_1We are honored to have published these seminal works that helped to elucidate the crucial role of spontaneously broken symmetry in our current understanding of the fundamental constituents of matter. Sincerely,
Gene D. Sprouse, Editor in Chief, American Physical Society Joseph W. Serene, Treasurer/Publisher, American Physical Society
In the advance online edition of Nature Medicine investigators show that the accumulation of succinate in the hypoxic retina of rodents is a potent mediator of vessel growth via GPR91. Effects of the receptor are mediated by retinal ganglion neurons which, in response to higher succinate levels, regulate a number of angiogenic factors including VEGF (vascular endothelial growth factor). The observations show a pathway of signaling were succinate, acting through GPR91, governs retinal angiogenesis.
Scientists from Sainte-Justine Hospital Research Center, the Université de Montréal and the Institut national de la santé et de la rechercher médicale(INSERM) in France report provide results that imply biological functions for succinate beyond energy production. Of therapeutic importance is that these findings have implications for halting blinding diseases such as retinopathy of prematurity in infants, diabetic retinopathy in adults or age-related macular degeneration in seniors. There are also implications related to stopping tumor growth by interfering with the GPR91 receptor and preserving neurons after trauma by activating the GPR91 receptor to help salvage neurons in damaged brain tissue following stroke or head injuries.
The reported studies took place in animals, however GPR91 is also found in humans. An October 7, 2008 Science Daily article reports that the research could be extended to human clinical investigations in three to four years.