Related Readings – Dominique Frueh Ph.D.

Dynamic Communication in Nonribosomal Peptide Synthetases:

The T-TE Di-domain of Enterobactin Synthetase

Monday, March 31, 2008

Welch Hall    Markus Library Level Two     4 p.m.     Refreshments at 3:45 p.m.

Recommended Review Article:

Donadio, S.; Monciardini, P; and m. Sosio. (2007). Polyketide synthases and nonribosomal peptide synthetases: the emerging view from bacterial genomics.   Natural Products Reports. 24(5): 1073-1109

Related Articles:

Wilkinson, B. and J. Micklefield. (2007). Mining and engineering natural-product biosynthetic pathways.   Nature Chemical Biology   3(7):379-386

Tang, G.L.; YQ. Cheng; and B. Shen. (2007). Chain initiation in the leinamycin-producing hybrid nonribosomal peptide/polyketide synthetase from Streptomyces atroolivaceus S-140 – Discrete, monofunctional adenylation enzyme and peptidyl carrier protein that directly load D-Alanine.  Journal of Biological Chemistry  282(28):20273-20282

Zhou, Z.; Lai, J. R.; and Walsh, C.T. (2006). Interdomain communication between the thiolation and thioesterase domains of EntF explored by combinatorial mutagenesis and selection.  Chemistry & Biology   13(8):869-879

Doekel, S. (2000). Dipeptide formation on engineered hybrid peptide synthetases. Chemistry & Biology  7(6):373-384

Samuel, S.A. (2006) The thioesterase domain of the fengycin biosynthesis cluster: a structural base for the macrocyclization of a non-ribosomal lipopeptide. Journal of Molecular Biology  359:876-889

Shawreid, C.A. (1999). Assembly line enzymology by multimodular nonribosomal peptide synthetases: the thioesterase domain of E-coli EntF catalyzes both elongation and cyclolactonization. Chemistry & Biology 6(6):385-400

Library Opens New Exhibit on Scientific Instruments

Markus Library presents the third in a series of exhibits highlighting the Merrill W. Chase Historic Instrument Collection. The current exhibit, “Tools for Discovery: Made at Rockefeller,” features instruments designed and made at The Rockefeller University in the Instrument, Glassblowers’ and Electronics Shops to meet scientists’ specific experimental needs.

For much of the twentieth century The Rockefeller University was unique in having skilled craftsmen: Josepf Blum, Nils Jernberg, Otto Hopf, Robert Schoenfeld, Elko Machek, and many others. Their everyday work ranged from repairing existing instruments to designing and producing one-of-a-kind devices such as a digital programmer, centrifuges, microtome, ellipsometer, and peptide synthesizerm all of which were so useful that they went into commercial production.

Please visit the exhibit on the second level of Welch Hall from March through December, 2008.

Idea and Design: Olga Nilova
Consultants: Peter Sellers and Carol Moberg, Curators of Scientific Instrument Collection
Archival Support: Meg Hogan
Graphics: Vincent Furno

This exhibit is dedicated to the memory of Gregory Nilov.

Related Readings – Mikala Egeblad Ph.D.

Seeing Tumors in Context:

New Insights into the Dynamics of the Tumor Microenvironment

Monday, March 24, 2008

Welch Hall    Markus Library Level Two    4 p.m.     Refreshments at 3:45 p.m.

Recommended Review Article:

Bissell, M. J. and D. Radisky (2001). Putting tumors in context.  Nature Reviews Cancer. 1(1): 46-54


Related Articles:

Kouros-Mehr, H; S. K. Bechis and E. M. Slorach et al.  (2008). GATA-3 links tumor differentiation and dissemination in a luminal breast cancer model. Cancer Cell. 13(2): 141-152

Maata, J.A.; M. Sundivall; T.T. Junttila et al.   (2006). Proteolytic cleavage and phosphorylation of a tumor-associated ErbB4 isoform promote ligand-independent survival and cancer cell growth.  Molecular Biology of the Cell. 17(1):67-79

Littlepage, L.E. and M. Egeblad.  (2005). Coevolution of cancer and stromal cellular responses. Cancer Cell.  7(6):499-500

Li, Y; B. Welm; and K. Podsypanina. (2003). Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells.  PNAS. 100(26):15853-15858

Related Readings: Eric M. Morrow M.D.

Autosomal Recessive Mutations Identified in Autism in

Special Founder Populations

Monday, March 10, 2008

Welch Hall  Markus Library  Level Two  4 p.m. Refreshments at 3:45 p.m.

Recommended Review Article:

Morrow, Eric M. and Jordan W. Smoller. (2006). The interface of genetics and clinical psychiatry. Introduction.  Harvard Review of Psychiatry. 14(2): 45-56

Related Articles:

Morrow, Eric M. et al.  (2007).  Autosomal recessive loci in familial autisms using a systematic homozygosity mapping strategy.  Biological Psychiatry   61(8 supple. S):10s

Ma, D. Q. et al.  (2005).  Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism. American Journal of Human Genetics 77(3):377-388

Kumadas,  S; Akcakus, M; Coskun, A; and H. Gumus.  (2004).  Joubert syndrome: review and report of seen new cases. European Journal of Neurology 11(8):505-510

Levine, John C; Morrow, Eric M; Berdichevsky, Yevgeny; and Gilles E. Martin. (2007). BKca channel in autism and mental retardation.  American Journal of Psychiatry. 164(6):978-979

Sikora, Darryn M. et al.  (2006)  The near universal presence of autism spectrum disorders in children with Smith-Lemli-Opitz syndrome.  American Journal of Medical Genetics A  140(14):1511-1518