Related Readings – Satinder Kaur Singh, Ph.D.

Antidepressant Binding Site in a Bacterial Homologue of Neurotransmitter Transporters

Tuesday, February 19, 2008
Welch Hall (2nd Floor)

3:45 p.m. Refreshments 4:00 p.m. Lecture

Figure 3 from Singh et al. (2007) Nature 448:952-956.

Figure 3. Clomipramine-binding site. From Singh at al. (2007) Nature 448:952-956.

Recommended Review Article

Gether, U., Andersen, P. H., Larsson, O. M. and Schousboe, A. (2006). Neurotransmitter transporters: molecular function of important drug targets. Trends in Pharmacological Sciences 27:375-383.

Related Articles

Rudnick, G. (2007). What is an antidepressant binding site doing in a bacterial transporter? ACS Chemical Biology 2:606-609.
Singh, S. K., Yamashita, A. and Gouaux, E. (2007). Antidepressant binding site in a bacterial homologue of neurotransmitter transporters. Nature 448:952-956.
Yamashita, A., Singh, S. K., Kawate, T., Jin, Y. and Gouaux, E. (2005). Crystal structure of a bacterial homologue of Na+/Cl–dependent neurotransmitter transporters. Nature 437:215-223.
Zhou, Z., Zhen, J., Karpowich, N. K., Goetz, R. M., Law, C. J., Reith, M. E. A. and Wang, D. N. (2007). LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake. Science 317:1390-1393.

Related Readings – Frederick W. Alt, Ph.D.

IgH Class Switching, DNA Breaks, Translocations and Cancer

Friday, February 15, 2008

Caspary Auditorium 3:45 p.m. – 5:00 p.m. Tea at 3:15 p.m. in the Abby Lounge

Figure 1 Chaudhuri and Alt (2004) Nature Reviews Immunology 4:541-552.

Figure 1. Rearrangement at the immunoglobulin heavy-chain locus. From Chaudhuri and Alt (2004) Nature Reviews Immunology 4:541-552.

Recommended Review Article

Chaudhuri, J. and Alt, F. W. (2004). Class-switch recombination: Interplay of transcription, DNA deamination and DNA repair. Nature Reviews Immunology 4:541-552.

Further Reading

Dudley, D. D., Chaudhuri, J., Bassing, C. H. and Alt, F. W. (2005). Mechanism and control of V(D)J recombination versus class switch recombination: Similarities and differences. Advances in Immunology 86:43-112.

Related Articles

Franco, S., Alt, F. W. and Manis, J. P. (2006). Pathways that suppress programmed DNA breaks from progressing to chromosomal breaks and translocations. DNA Repair 5:1030-1041.
Jankovic, M., Nussenzweig, A. and Nussenzweig, M. C. (2007). Antigen receptor diversification and chromosome translocations. Nature Immunology 8:801-808.
Wuerffe, R., Wang, L., Grigera, F., Manis, J., Selsing, E., Perlot, T., Alt, F. W., Cogne, M., Pinaud, E. and Kenter, A. L. (2007). S-S synapsis during class switch recombination is promoted by distantly located transcriptional elements and activation-induced deaminase. Immunity 27:711-722.
Yan, C. T., Boboila, C., Souza, E. K., Franco, S., Hickernell, T. R., Murphy, M., Gumaste, S., Geyer, M., Zarrin, A. A., Manis, J. P., Rajewsky, K. and Alt, F. W. (2007). IgH class switching and translocations use a robust non-classical end-joining pathway. Nature 449:478-482.
Zarrin, A. A., Del Vecchio, C., Tseng, E., Gleason, M., Zarin, P., Tian, M. and Alt, F. W. (2007). Antibody class switching mediated by yeast endonuclease-generated DNA breaks. Science 315:377-381.