Related Readings – Danica Galonic Fujimori, Ph.D.

Halogenation of Unactivated Carbon Centers in Natural Products Biosynthesis

Monday, February 11, 2008
Welch Hall (2nd Floor)

3:45 p.m. Refreshments 4:00 p.m. Lecture

Figure 1 from Fujimori et al. (2007) Journal of the American Chemical Society 129:13408-13409.

Figure 1. The 4.2-K Mössbauer spectra of a sample of the CytC3 Fe(II) αKG L-Aba-S-CytC2 Br complex that was reacted with O2 for 2 s. From Fujimori at al. (2007) Journal of the American Chemical Society 129:13408-13409.

Recommended Review Article

Vaillancourt, F. H., Yeh, E., Vosburg, D. A., Garneau-Tsodikova, S. and Walsh, C. T. (2006). Nature’s inventory of halogenation catalysts: Oxidative strategies predominate. Chemical Reviews 106:3364-3378.

Related Articles

Fujimori, D. G., Barr, E. W., Matthews, M. L., Koch, G. M., Yonce, J. R., Walsh, C. T., Bollinger, J. M., Krebs, C. and Riggs-Gelasco, P. J. (2007). Spectroscopic evidence for a high-spin Br-Fe(IV)-oxo intermediate in the alpha-ketoglutarate-dependent halogenase CytC3 from Streptomyces. Journal of the American Chemical Society 129:13408-13409.
Fujimori, D. G., Hrvatin, S., Neumann, C. S., Strieker, M., Marahiel, M. A. and Walsh, C. T. (2007). Cloning and characterization of the biosynthetic gene cluster for kutznerides. Proceedings of the National Academy of Sciences 104:16498-16503.
Fujimori, D. G. and Walsh, C. T. (2007). What’s new in enzymatic hallogenations. Current Opinion in Chemical Biology 11:553-560.
Galonic, D. P., Barr, E. W., Walsh, C. T., Bollinger, J. M. and Krebs, C. (2007). Two interconverting Fe(IV) intermediates in aliphatic chlorination by the halogenase CytC3. Nature Chemical Biology 3:113-116.
Galonic, D. P., Vaillancourt, F. H. and Walsh, C. T. (2006). Halogenation of unactivated carbon centers in natural product biosynthesis: Trichlorination of leucine during barbamide biosynthesis. Journal of the American Chemical Society 128:3900-3901.