Related Readings – Monday Lecture – Mike Young, Ph.D.

PER/TIM Interval Timer for Drosophila’s Circadian Clock

Monday, December 17, 2007
Welch Hall (2nd Floor)

3:45 p.m. Refreshments 4:00 p.m. Lecture

Figure 1 from Hardin (2005) Current Biology 15:R714-R722.

Figure 1. Model of the Per/Tim feedback loop. From Hardin (2005) Current Biology 15:R714-R722.

Recommended Review Article

Hardin, P. E. (2005). The circadian timekeeping system of Drosophila. Current Biology 15:R714-R722.

Related Articles

Boothroyd, C. E., Wijnen, H., Naef, F., Saez, L. and Young, M. W. (2007). Integration of light and temperature in the regulation of circadian gene expression in Drosophila. PLoS Genetics 3:e54.
Cyran, S. A., Yiannoulos, G., Buchsbaum, A. M., Saez, L., Young, M. W. and Blau, J. (2005). The double-time protein kinase regulates the subcellular localization of the Drosophila clock protein period. Journal of Neuroscience 25:5430-5437.
Meyer, P., Saez, L. and Young, M. W. (2006). PER-TIM interactions in living Drosophila cells: An interval timer for the circadian clock. Science 311:226-229.
Wijnen, H., Naef, F. and Young, M. W. (2005). Molecular and statistical tools for circadian transcript profiling. Methods in Enzymology 393:341-365.
Wijnen, H. and Young, M. W. (2006). Interplay of circadian clocks and metabolic rhythms. Annual Review of Genetics 40:409-448.

Related Readings – Frederick R. Cross, Ph.D.

Single-cell Analysis of Regulatory Dynamics and Noise in the Yeast Cell Cycle

December 10, 2007

Welch Hall (2nd Floor)

3:45 p.m. Refreshments 4:00 p.m. Lecture

Figure 4 from Figure 4 from Bloom and Cross (2007) Nature Reviews Molecular Biology 8:149.

Figure 4. Signalling pathways that regulate cyclins. From Bloom and Cross (2007) Nature Reviews Molecular Biology 8:149.

Recommended Review Article

Bloom, J. and Cross, F. R. (2007). Multiple levels of cyclin specificity in cell-cycle control. Nature Reviews Molecular Cell Biology 8:149-160.

Related Articles

Di Talia, S., Skotheim, J. M., Bean, J. M., Siggia, E. D. and Cross, F. R. (2007). The effects of molecular noise and size control on variability in the budding yeast cell cycle. Nature 448:947-951.
Ikui, A. E., Archambault, V., Drapkin, B. J., Campbell, V. and Cross, F. R. (2007). Cyclin and cyclin-dependent kinase substrate requirements for preventing rereplication reveal the need for concomitant activation and inhibition. Genetics 175:1011-1022.

Related Readings – Friday Lecture – Catherine Dulac, Ph.D.

Sex and Smell: Molecular Biology of Pheromone Perception in Mammals

Friday, December 7, 2007

Caspary Auditorium 3:45 p.m. – 5:15 p.m. Tea at 3:15 p.m. in the Abby Lounge

Figure 3 from Dulac and Wagner (2006) Annual Review of Genetics 40:449-467.

Figure 3. Cellular architecture of the main olfactory and vomeronasal systems. From Dulac and Wagner (2006) Annual Review of Genetics 40:449-467.

Recommended Review Article

Dulac, C. and Wagner, S. (2006). Genetic analysis of brain circuits underlying pheromone signaling. Annual Review of Genetics 40:449-467.

Related Articles

Dulac, C. and Torello, A. T. (2003). Molecular detection of pheromone signals in mammals: From genes to behaviour. Nature Reviews Neuroscience 4:551-562.
Olson, R., Dulac, C. and Bjorkman, P. J. (2006). MHC homologs in the nervous system – they haven’t lost their groove. Current Opinion in Neurobiology 16:351-357.
Tietjen, I., Rihel, J. M., Cao, Y. X., Koentges, G., Zakhary, L. and Dulac, C. (2003). Single-cell transcriptional analysis of neuronal progenitors. Neuron 38:161-175.
Wagner, S., Gresser, A. L., Torello, A. T. and Dulac, C. (2006). Multireceptor genetic approach uncovers an ordered integration of VNO sensory inputs in the accessory olfactory bulb. Neuron 50:697-709.