Related Readings – Monday Lecture – Hina W. Chaudhry, M.D.

Cyclins and Stem Cells in Cardiac Regeneration

Monday, June 4, 2007
Welch Hall (2nd Floor)

3:45 p.m. Refreshments 4:00 p.m. Lecture

Recommended Review Article

Rubart, M. and Field, L. J. (2006).Cardiac regeneration: Repopulating the heart. Annual Review of Physiology 68:29-49.

Related Articles

Anversa, P., Leri, A., Rota, M., Hosoda, T., Bearzi, C., Urbanek, K., Kajstura, J. and Bolli, R. (2007).Concise review: Stem cells, myocardial regeneration, and methodological artifacts. Stem Cells 25:589-601.
Chaudhry, H. W., Dashoush, N. H., Tang, H. Y., Zhang, L., Wang, X. Y., Wu, E. X. and Wolgemuth, D. J. (2004).Cyclin A2 mediates cardiomyocyte mitosis in the postmitotic myocardium. Journal of Biological Chemistry 279:35858-35866.
Chaudhry, H. W. and Wolgemuth, D. J. (2006). Compositions and methods for treating and preventing heart tissue degeneration and uses thereof. U.S. Patent Application (Published) 20060160733; 2006 July 20.
Murry, C. E., Reinecke, H. and Pabon, L. M. (2006).Regeneration gaps – Observations on stem cells and cardiac repair. Journal of the American College of Cardiology 47:1777-1785.
Woo, Y. J., Panlilio, C. M., Cheng, R. K., Liao, G. P., Atluri, P., Hsu, V. M., Cohen, J. E. and Chaudhry, H. W. (2006).Therapeutic delivery of cyclin A2 induces myocardial regeneration and enhances cardiac function in ischemic heart failure. Circulation 114:I206-I213.

Related Readings – Friday Lecture – David J. Anderson, Ph.D.

The Neural Basis of Innate Behavior: From Genes to Circuits

Friday, May 25, 2007

Caspary Auditorium 3:45 p.m. – 5:15 p.m. Tea at 3:15 p.m. in the Abby Lounge

Recommended Review Article

Manoli, D. S., Meissner, G. W. and Baker, B. S. (2006).Blueprints for behavior: genetic specification of neural circuitry for innate behaviors. Trends in Neurosciences 29:444-451.

Related Articles

Billeter, J. C., Villella, A., Allendorfer, J. B., Dornan, A. J., Richardson, M., Gailey, D. A. and Goodwin, S. F. (2006).Isoform-specific control of male neuronal differentiation and behavior in Drosophila by the fruitless gene. Current Biology 16:1063-1076.
Carvalho, G. B., Kapahi, P., Anderson, D. J. and Benzer, S. (2006).Allocrine modulation of feeding behavior by the sex peptide of Drosophila. Current Biology 16:692-696.
Choi, G. B., Dong, H. W., Murphy, A. J., Valenzuela, D. M., Yancopoulos, G. D., Swanson, L. W. and Anderson, D. J. (2005).Lhx6 delineates a pathway mediating innate reproductive behaviors from the amygdala to the hypothalamus. Neuron 46:647-660.
Suh, G. S. B., Wong, A. M., Hergarden, A. C., Wang, J. W., Simon, A. F., Benzer, S., Axel, R. and Anderson, D. J. (2004).A single population of olfactory sensory neurons mediates an innate avoidance behaviour in Drosophila. Nature 431:854-859.

Related Readings – Friday Lecture – Carolyn R. Bertozzi Ph.D.

Shedding Light on Glycans

Friday, May 18, 2007

Caspary Auditorium 3:45 p.m. – 5:15 p.m. Tea at 3:15 p.m. in the Abby Lounge

Recommended Review Article

Dube, D. H. and Bertozzi, C. R. (2005).Glycans in cancer and inflammation. Potential for therapeutics and diagnostics. Nature Reviews Drug Discovery 4:477-488.

Related Articles

Agard, N. J., Baskin, J. M., Prescher, J. A., Lo, A. and Bertozzi, C. R. (2006).A comparative study of bioorthogonal reactions with azides.
ACS Chemical Biology 1:644-648.
Prescher, J. A. and Bertozzi, C. R. (2005).Chemistry in living systems. Nature Chemical Biology 1:13-21.
Raman, R., Raguram, S., Venkataraman, G., Paulson, J. C. and Sasisekharan, R. (2005).Glycomics: an integrated systems approach to structure-function relationships of glycans. Nature Methods 2:817-824.
Timmer, M. S. M., Stocker, B. L. and Seeberger, P. H. (2007).Probing glycomics. Current Opinion in Chemical Biology 11:59-65.

Related Readings – Monday Lecture – Hironori Funabiki, Ph.D.

Signals On and Off Chromosomes

Monday, May 14, 2007
Welch Hall (2nd Floor)

3:45 p.m. Refreshments 4:00 p.m. Lecture

Recommended Overview Article

Saric, T. and Goldberg, A.L. (Article Online Posting Date: January 27,2006).Protein degradation and turnover. In: Encyclopedia of Life Sciences. John Wiley & Sons, Ltd.

Related Articles

Kelly, A. E., Sampath, S. C., Maniar, T. A., Woo, E. M., Chait, B. T. and Funabiki, H. (2007).Chromosomal enrichment and activation of the Aurora B pathway are coupled to spatially regulate spindle assembly. Developmental Cell 12:31-43.
Pickart, C. M. (2004).Back to the future with ubiquitin. Cell 116:181-190.
Walker, J. R., Corpina, R. A. and Goldberg, J. (2001).Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair. Nature 412:607-614.
Wyman, C. and Kanaar, R. (2006).DNA double-strand break repair: All’s well that ends well. Annual Review of Genetics 40:363-383.

Related Readings – Friday Lecture – Irving L. Weissman, M.D.

Normal and Neoplastic Stem Cells

Recommended Review Article

Dalerba, P., Cho, R. W. and Clarke, M. F. (2007).Cancer stem cells: Models and concepts. Annual Review of Medicine 58:267-284.

Related Articles

Jordan, C. T., Guzman, M. L. and Noble, M. (2006).Mechanisms of disease – Cancer stem cells. New England Journal of Medicine 355:1253-1261.
Pardal, R., Clarke, M. F. and Morrison, S. J. (2003).Applying the principles of stem-cell biology to cancer. Nature Reviews Cancer 3:895-902.
Reya, T., Morrison, S. J., Clarke, M. F. and Weissman, I. L. (2001).Stem cells, cancer, and cancer stem cells. Nature 414:105-111.
Tan, B. T., Park, C. Y., Ailles, L. E. and Weissman, I. L. (2006).The cancer stem cell hypothesis: a work in progress. Laboratory Investigation 86:1203-1207.
Weissman, I. (2005).Stem cell research – Paths to cancer therapies and regenerative medicine. JAMA-Journal of the American Medical Association 294:1359-1366.

Related Readings – Monday Lecture – Christian Munz, Ph.D.


Innate and Adaptive Immunity through Autophagy

Monday, May 7, 2007
Welch Hall (2nd Floor)

3:45 p.m. Refreshments 4:00 p.m. Lecture

Recommended Review Article

Hislop, A.D., Taylor, G.S., Sauce, D. and Rickinson, A.B. (2007).Cellular responses to viral infection in humans: lessons from Epstein-Barr virus. Annual Review of Immunology 25:587-617.

Related Articles

Deretic, V. (2006).Autophagy as an immune defense mechanism. Current Opinion in Immunology 18:375-382.
Heller, K. N., Gurer, C. and Munz, C. (2006).Virus-specific CD4(+) T cells: ready for direct attack. Journal of Experimental Medicine 203:805-808.
Munz, C. (2006).Autophagy and antigen presentation. Cellular Microbiology 8:891-898.
Paludan, C., Schmid, D., Landthaler, M., Vockerodt, M., Kube, D., Tuschl, T. and Munz, C. (2005).Endogenous MHC class II processing of a viral nuclear antigen after autophagy. Science 307:593-596.
Schmid, D. and Munz, C. (2005).Immune surveillance of intracellular pathogens via autophagy. Cell Death and Differentiation 12:1519-1527.

Related Readings – Friday Lecture – Cynthia Kenyon, Ph.D.


Genes and Cells that Influence the Aging of C. elegans

Friday, May 4, 2007

Caspary Auditorium 3:45 p.m. – 5:15 p.m. Tea at 3:15 p.m. in the Abby Lounge

Recommended Review Article

Kenyon, C. (2005).The plasticity of aging: Insights from long-lived mutants. Cell 120:449-460.

Related Articles

Guarente, L. and Kenyon, C. (2000).Genetic pathways that regulate ageing in model organisms. Nature 408:255-262.
Hansen, M., Hsu, A. L., Dillin, A. and Kenyon, C. (2005).New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen. PLoS Genetics 1:119-128.
Libina, N., Berman, J. R. and Kenyon, C. (2003).Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan. Cell 115:489-502.
McCarroll, S. A., Murphy, C. T., Zou, S. G., Pletcher, S. D., Chin, C. S., Jan, Y. N., Kenyon, C., Bargmann, C. I. and Li, H. (2004).Comparing genomic expression patterns across species identifies shared transcriptional profile in aging. Nature Genetics 36:197-204.
Murphy, C. T., McCarroll, S. A., Bargmann, C. I., Fraser, A., Kamath, R. S., Ahringer, J., Li, H. and Kenyon, C. (2003).Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature 424:277-284.